Q. Can allergic reaction occur due to Tylenol 3 or Amoxicillin?

Answered by
Dr. Pooja Pardhi
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Jun 14, 2018 and last reviewed on: Sep 16, 2020

Hi doctor,

Yesterday, I had my wisdom tooth extracted. I received a prescription for Tylenol 3 (equivalent to Acetaminophen 300 mg and Codeine 30 mg) for pain and Amoxicillin (500 mg) to prevent infection. I immediately took one Amoxicillin as I walked out of the dental office and for the rest of the day I had no reaction. Later just before going to sleep I took one Amoxicillin along with one Tylenol 3. The next day I woke up with an anaphylactic reaction to the groin and inner thighs. I am trying to diagnose whether it was due to Tylenol 3, the Amoxicillin or may be due to the combination. As there was not that much pain I have decided to halt the use of Tylenol 3 and I am waiting to see if the reaction resolves. However, I do know that many people are allergic to this family of antibiotics. I am wondering if this may be the case for me as well, but I have never had an allergic reaction before. I am sure that I have taken this family of antibiotics previously, though I am not certain.



Welcome to

I have gone through your query and can understand your health concern.

  • The allergic reaction can be due to Amoxicillin only, because Acetaminophen and Codeine will not cause any allergic reaction.
  • I suggest you to stop Amoxicillin. You can use any of the Cephalosporin instead of Amoxicillin.
  • For allergic reaction, I suggest some antihistamine drug twice daily for three days.
  • Amoxicillin and other drugs of this group are very common to cause allergic reactions.
  • As you have mentioned that you never developed such reaction in the past and this is the first time, I tell you that it can happen. I suggest you not to take Amoxicillin in the future.

For further information consult an allergy specialist online -->

Was this answer helpful?


Same symptoms doesn’t mean you have the same problem. Consult a doctor now!

Related Questions:
Why did I develop hives after tattoo?

.. syndrome is a very common manifestation due to allergy to allergens like pollen, raw fruits, vegetables or some tree nuts. The immune system recognizes the pollen as foreign substance and directs an allergic response to it. The symptoms are usuall...   Read full

Shall I take Amoxicillin for cough?

.. have recurrent infection, I would suggest to do investigations first. Currently, I suggest tablet Amoxicillin plus Clavulanic acid (Co-amoxiclav) 625 mg three times a day for seven days .. ...   Read full

Please help with my allergic reaction to cherries.

.. an allergic reaction and there is no need to worry. I suggest antihistamines and tablet Montek-LC containing Montelukast with Levocetirizine. I also suggest antacids along with that. Consult your doctor, discuss with him or her and take the medici...   Read full


Also Read Answers From:

ideaComprehensive Medical Second Opinion.Submit your Case

Also Read

Management of Coronasomnia
Coronasomnia refers to increased sleep problems among people during the COVID-19 pandemic. Read the below article to get...  Read more»
Balantidiasis - Causes, Signs and Symptoms, Diagnosis, Treatment, and Prevention
Balantidiasis is a rare bacterial infection caused by a parasite called Balantidium coli. Read the article below to know...  Read more»
JAK Inhibitors in Treating Rheumatoid Arthritis
Doctors mainly suggest JAK or Janus kinase inhibitors for patients with rheumatoid arthritis to ease their symptoms. Rea...  Read more»

Ask your health query to a doctor online?

Ask an Allergy Specialist Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.