HomeAnswersVenereologygenital ulcerHow to confirm whether my genital ulcer is due to syphilis or herpes?

I have a genital ulcer for the past few days. What could it be?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

Dr. Vinodhini J.

Published At January 4, 2021
Reviewed AtJune 27, 2023

Patient's Query

Hello doctor,

I have a genital ulcer for many days, and I do not know what is going on. I am a medical student and thinking about two causes, genital herpes or syphilis. I had an sexually transmitted disease (STD) test for both and took treatment for this. Personally, it reminds me of herpes, and I have started taking Valacyclovir 1000 mg twice daily, but I cannot see any difference. What is your opinion? Generally, I am a carrier of herpes simplex virus (HSV) 1, and I have lip herpes when I was a little child. Now, I am 24 years old. But three years ago, I was diagnosed with syphilis. I took Penicillin G, and the problem was over. I do not think that this current ulcer is a syphilis ulcer, but I am not sure.

Hello,

Welcome to icliniq.com.

There are many differential diagnoses of genital ulcer-like herpes genitalis, primary chancre, beaches, chancroid, gonorrhea, STI, etc. Have you done VRDL, TPHA, and FTA-Abs tests? If the tests come reactive or positive, take a tablet of Doxycycline 100 mg twice daily after food for two to four weeks. It depends on the stage of syphilis. Apply Fucidin cream twice daily for seven days. Take tablet Emanzen D twice daily for three days (if painful). Do you have any constitutional symptoms like sore throat, malaise, headache, weight loss, fever, rashes, or muscle pain? Do you have any lymphadenopathy or mucosal lesions other than this? Do you have alopecia, split papules at the angle of the mouth, or mucous patches on the lips? Do you have a tingling or burning sensation?

It seems to be genital herpes as syphilis ulcer presents as a penile snail track ulcer. Have you done HSV 2 IgG, and IgM tests? Do you have any test reports?

Please revert back.

Patient's Query

Hello doctor,

I do not take VDRL, RPR, TPHA, or FTA tests for this ulcer. Also, I do not take any tests for HSV 1 and 2. I am taking Valacyclovir 1000 mg orally (today is the 6th day), but I do not see any difference. If it was herpes, Valacyclovir should not help. Yesterday, I had a headache, a fever of 38.2, and myalgia but only for one day. I took Paracetamol and Ibuprofen for the whole day, and today I am fine. I have a tingling sensation and burning. My ELISA test for HIV is negative.

I am worried because I am taking antiviral therapy Valacyclovir, and I do not see any difference. We are on the 6th day today. How long does the treatment last?

Hello,

Welcome back to icliniq.com.

Before starting the treatment, get blood investigations and urine culture done and confirm the infection's cause.

In herpes tablets, Acyclovir 400 mg thrice daily for five days, or Valacyclovir 500 mg tablet twice daily for three days is given. It depends on whether the infection is primary or recurrent.

You can start applying topical creams without investigation. Apply Sodium Fusidate cream or Fucidin cream twice daily in the morning and evening for seven days, and Mupirocin ointment at night for 10 days.

You can also take the tablet Pregaba M (Pregabalin and Mecobalamin), one tablet twice daily for 15 days, or a Neurobion forte tablet twice daily for 15 days. Apply Acyclovir 1 percent gel three times daily for 10 days (if available), and Melipox spray to soothe lesions.

Are you sexually active?

Patient's Query

Hello doctor,

The correct medical intervention is getting tested by a blood test or urine culture. I know this, and I agree with you. But the labs remain closed. When they get opened, I will get tested for all STDs. HIV makes me scared because I am gay. I am very careful in my sexual activities and always use a condom. I am afraid of HIV because it provokes chronic infection. So, I am very careful, but the condom is not so protective against herpes, syphilis, chlamydia, etc., because they are transmitted more easily. Before entering medical school for three years, I got tested for everything, and I found out that I was VDRL positive. Also, RPR is 1/32 positive. I took Benzylpenicillin, and the infection was over. I am always afraid of STDs. The previous year, I again had the same problem with now, and the labs showed that I had HSV 1 and not HSV 2 in my genitalia. Yes, I have HSV 1 and not 2. There are some cases that HSV 1 spreads in the genitalia. I took Valacyclovir, and it disappeared.

But I think that herpes in the penis is not appeared by sexual activity. I am very stressed, and I have pathological anxiety. I am not taking any medication and trying to manage this. I do not have good psychology because I have many family problems with my parents and brother. And this makes me sad and probably dropped my immune system down. You will see in the pictures that I also have something on my lips. I do not sleep well, anxious, and all these help the presence of herpes.

My question is, with Valacyclovir 1000 mg should not this herpes be better? Do you think that is genital herpes, or do you have suspension for something else like syphilis or something else?

Hello,

Welcome back to icliniq.com.

I have seen the picture (attachment removed to protect patient's identity). This is balanitis (inflammation or swelling) of the penis. The cause of balanitis could be a bacterial, viral, or fungal infection and STI.

It appears like herpes with secondary bacterial infection due to scratching or rubbing of the lesion. But if antiviral treatment is not responding, there are more chances of bacterial or fungal infection. Usually, antiviral treatment show results in seven days.

Genital hygiene plays a vital role in this case. Maintain proper genital hygiene. Wash genitals daily with lukewarm water and mild cleansers like Episoft cleanser or no soap cleanser or Cetaphil cleanser.

Avoid scratching or rubbing of lesions. Keep the area dry and clean. Avoid occlusion and friction. Wear loose, comfortable thin cotton inners. And avoid tight clothes and inners.

Stay in a well-ventilated cool environment and avoid a humid environment. Use barrier. Avoid multiple partners. Refrain from sex until complete healing of lesions. Avoid stress as it may cause aggravation in herpes.

Apply Fucidin cream twice daily for seven days and use Candid cream at night for seven days. Do all tests and follow up with reports. There will be an improvement if the exact cause is found and treated accordingly to prevent a recurrence.

Patient's Query

Hello doctor,

After 6 days of our last communication, I am sending you again some photos of my penis lesions. Do you believe that we have an improvement in herpes?

Hello,

Welcome back to icliniq.com,

There is improvement seen in the lesions.

But balanitis is present. To reduce inflammation and swelling, apply 1 percent Hydrocortisone cream twice daily in very little quantities for 10 days. Apply candid cream or Miconazole gel at night for 15 days. Continue Fucidin cream twice daily for 7 days. Are any symptoms at present? Done all tests? Previous treatment has taken? Which treatment was taken in these 6 days?

Patient's Query

Hello doctor,

I had an open appendectomy because of acute appendicitis. Everything is okay now, I am staying home and recovering. Before and after the surgery I took some antibiotics (Metronidazole and Cefuroxime). I am also taking the tablet Cefuroxime 500 mg daily for 5 days (every 12 hours). Do you think that this antibiotic might improve inflammation? I did not do any tests because I felt the perceptible pain in the right down the side of the abdomen and I was scared so went directly to the hospital. On the previous days, I took valacyclovir 1000 mg for 7 days. I was also putting Kenacomb cream on the lesions. Kenacomb included triamcinolone, Nystatin, and Neomycin. Do you think that this balanitis is caused by herpes? Generally, from when I was a little child I had many balanitis in the past, leading to phimosis. I am worried that this was not a herpes infection. Are you still excluding some other infections? Syphilis for example or something else?

Hello,

Welcome back to icliniq.com.

Do not use Betnovate. Balanitis can occur due to improper hygiene, scratching or rubbing, allergic reaction to irritant soap, and infection like yeast infection, chlamydia, and fungal infection. These are the possible causes that need to be ruled out so recurrence can be prevented. Avoid possible irritants. Practice good hygiene, safe sex and use barrier. A swab test is done to check for infection (a swab from the glans is taken). Also, a biopsy can tell the exact cause (a sample from a lesion or inflamed skin is taken). Urine test and blood test-STI panel test are done. Treatment for balanitis is antibiotic cream or anti-fungal cream and steroid ointment. Avoid scented soap or lotions. Always clean the glans after retracting the foreskin. Wash with warm water. Use a neutral cleanser like Episoft cleanser or no soap cleanser to clean genitals, as hygiene plays a very important role in this case. Clean and dry the area. Always wash your private parts after sexual intercourse. Avoid self-medication as it may worsen the condition.

Patient's Query

Hello doctor,

I was applying Kenacomb and I saw a bit of improvement. Do you agree with this? So, I have to use Hydrocortisone 1 % cream. I was applying Kenacomb because it contains antifungal, antibiotic, and triamcinolone. I will upload it below. Do these red spots on the penis remind you of herpes? Okay, I do not apply Betnovate.

Hello,

Welcome back to icliniq.com.

Yes, You can Apply to Kenacomb for 10 days. Triamcinolone is also low potency steroid like 1 % Hydrocortisone. If inflammation reduces in these 10 days, no need to apply Hydrocortisone. If inflammation stays, then use 1 % hydrocortisone cream twice daily for 10 days. Herpetic lesions appear in groups in blisters from inflammatory papules, erosions, ulcers, and crust form mostly associated with a tingling sensation. These appear to be fungal infections Balanitis with a secondary bacterial infection. Also, anti-fungal medication improved the lesion. Also if a herpetic lesion, it usually improves in 7 to 10 days with crust formation without treatment, but may recur, to reduce the frequency of recurrence of herpes oral antivirals are given.

Any symptoms like a tingling sensation, pain, or tenderness?

Patient's Query

Hello doctor,

I am very scared because I just saw that this balanitis is getting worse. I thought that it was herpes and that this inflammation is going away but please see the pictures below. I do not know what is going on. Do you think that I have to go to a hospital and do a blood test?

Hello,

Welcome back to icliniq.com

If the genital ulcer is non-herpetic (dark blue kit is available for non-herpetic ulcers). Take tablet Doxycycline 100 mg twice daily after food for 15 days and tablet Azithromycin 1 gm for one day. Yes, you should get VDRL and all the above tests like swab test, biopsy, urine culture, and sensitivity report done. Start treatment after doing all tests and follow up with reports.

Patient's Query

Hello doctor,

VDRL will be positive because I had primary syphilis in the past, so write me also the treponemal reactions that I have to do. Does it not remind you of herpes anymore? Do we think that is syphilis? I will get tested.

Hello,

Welcome back to icliniq.com.

Get the following tests done.

  1. Urine routine.
  2. Urine culture and sensitivity test for chlamydia and gonorrhea etc.
  3. Blood test-serology (non-treponemal test).
  4. Treponemal test (FTA-Abs,TPHA) for syphilis.
  5. A swab test, biopsy-sample from a lesion, or inflamed skin are taken (to check for infection like LGV, or chancroid).
  6. HSV 1 and HSV 2 (IgG or IgM) for herpes.

Treatment for syphilis is Benzathine penicillin 2.4 million unit IM (1.2 million in each gluteal region). Take tablet Doxycycline 100 mg BD (twice daily after food) for 14 days with Azithromycin 1gm (500 mg twice) only once. It should be taken for the duration and dosage prescribed after confirmation of the investigation.

Patient's Query

Hello doctor,

I am sending you the answers to my laboratory tests. According to the tests, this was a herpetic infection HSV1 and the outcome took place in the genitalia. As you can see in tests, VDRL is negative. But in the FTA test we can see that IgG antibodies are 1:40 and 1:80 and the IgM are negative. All of these with negative VDRL.

Hello,

Welcome back to icliniq.com.

IgG test positive suggests positive infection in the past. IgG is high suggesting good immunity against herpes. HSV IgM if positive (suggest real indication of acute infection). IgM negative suggests there is no active infection at present. Take tablet Acyclovir 800 mg thrice daily (6 hourly) if signs of active infection are present. Apply Acyclovir gel or cream on lesions three to five times a day. Herpes active lesions will have painful blisters in groups with redness at the base. Syphilis and chancroid will have ulcers. Gonorrhea and chlamydia present pus from the urethra with discharge, and pain while urinating.

Patient's Query

Hello doctor,

Did you see my laboratory tests? VDRL is negative, FTA IgG 1:40 positive, and negative 1:80 how can this be expanded medically? I am okay now, the lesions were treated with Fucidin. I still believe that it was a herpes infection.

Hello,

Welcome back to icliniq.com

IgG positive suggests past infection (no active infection of herpes and syphilis now). Reports suggest past infection of HSV 1 (so lesions could be recurrent episodes of HSV 1 (sometimes HSV 1 can present with genital lesions also). Reports suggest past infection of syphilis as antibodies to syphilis antigen are present in the FTA test. The infection is gone.No present infection of syphilis. But clustering and recurrent episodes of HSV are common. It may cause intermittent episodes of genital sores though the frequency of recurrences decreases with time. The good part is it will go away with treatment but can recur. Herpes is a disease of nerves it will burn and itch initially but does not scratch the crust when they form. Change underwear every day. Maintain proper genital hygiene. Clean the area with lukewarm water twice daily. Avoid washing the area with any anti-septic soap or lotions. Wear loose cotton inners wears. Avoid intercourse. Use barriers.

I hope this has helped you.

Patient's Query

Hello doctor,

My psychology is not good and I am really trying not to be mad. This balanitis came back and I think that we have a herpes reoccurrence. But how is this possible? The lesions were going better with the combination of Fucidin or Kenacomb, I also took one box of Valtrex (valacyclovir) and this started to disappear but now we have again the same situation. I am crying the whole day and I do not know what to do. My laboratory tests also showed that I do not have a current infection neither of syphilis nor of herpes. Do you think that it is something else such as chlamydia or gonorrhea? But I do not have the symptoms of these infections, no yellowish penile pus, and no abdominal pain. I feel a bit of burning in urination and the lesions are painful when water touches them. What can we do please see the pictures.

Hello,

Welcome back to icliniq.com.

For chlamydia and syphilis, take a tablet of Doxycycline 100 mg two times daily for 14 days. If urine culture reports confirm chlamydia infection. For gonorrhea take Cipro XR (Ciprofloxacin extended release) 500 mg single dose or Levofloxacin 500 mg single dose. At present take Ciprofloxacin 500 mg twice daily for 5 days. Take tablet Azithromycin 500 mg once daily for 3 days and tablet Doxycycline 100 mg twice a day for 10 days. Testing for HIV should be done. Sore on genitals syphilis infection bears possibility. Get urine culture and sensitivity reports done. Also, repeated outbreaks of HSV are common but are usually shorter and less severe. Although the organism stays in the body for the rest of its life, the number of outbreaks tends to decrease over a period of years. Changes in the status of the immune system or due to stress, uncontrolled sugar levels, cytotoxic drugs, or thyroid, increase chances of HSV recurrence. Need to avoid risk factors and take precautions at the time of active infection. Possible risk factors could also be physical stress, mental, and emotional stress, recent illness, surgery, and prolonged sun exposure. These can trigger cold sores. HSV 1 is contagious during the active blisters stage.

  1. Apply Mupirocin 2 % cream twice daily with 1 percent Clotrimazole cream.
  2. Take a tablet of Levocetirizine 5 mg at night for 10 days (to relieve itching or burning).
  3. Protected sexual intercourse is advised.
  4. Take tablet Acyclovir 400 mg three times daily after a meal for 7 days.
  5. Take tablet Rantac (Ranitidine 150 mg) twice daily before meal for 7 days.
  6. Can Use Fucidin cream twice daily instead of Mupirocin.

I hope this has helped you.

Patient's Query

Hello doctor,

Both the ELISA test and PCR test show that I am HIV-negative. (I did PCR just to be sure 100 %). According to UTIs, do UTIs provoke ulcers in the penis? I mean that I do not have symptoms of a urinary tract infection. HPV infection is obvious. Chlamydia and gonorrhea have special symptoms that I do not have any of them. The problem is that when the sores were getting a bit better, I had sex with my partner. I am bottom gay so there is no use of condom for me. The penetration is anal to me. I have been tested for HIV, herpes, and syphilis and they are all negative.

Hello,

Welcome back to icliniq.com.

IgG antibody presence suggests that there was an infection in the past and now immunity has developed antibodies in order to fight those antigens. The values given in FTA-IgG mean that on quantifying the antibodies they were positive in the 1:40 titer and not in the 1:80 titer. Yes, it could be a herpes outbreak due to risk factors like stress.

  1. Take tablet Acyclovir 400 mg thrice daily after meals for 7 days. If it is a recurrent episode it may subside in 3 to 5 days.
  2. Apply Fucidin cream twice daily for 7 days.
  3. Avoid sex.

STI can cause ulcers. In chlamydia there is burning urination, erythema of urinary meatus, and painful ulcer so rule out all possible infections to prevent recurrence.

Patient's Query

Hello doctor,

Yes, I know that I have FTA IgG positive because I had primary syphilis in the past but I had taken penicillin G and now I am treated, and my VDRL is negative again. Also, IgM antibodies for HSV 1 are negative. IgG antibodies for HSV 1 are positive. No increased frequency of urination, no dysuria, and no painful urination.

Hello doctor,

I suggest you the following things.

  1. Take tablet Valacyclovir 500 mg twice daily after meals for 3 days.
  2. Fucidin cream twice daily in the morning and evening for 7 days.
  3. Mupirocin ointment at night for 10 days.
  4. Avoid Scratching or rubbing lesions.

I hope this has helped you.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Dhepe Snehal Madhav
Dr. Dhepe Snehal Madhav

Venereology

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