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HomeAnswersHematologyimmature granulocytesWhy is there an increase in the immature granulocytes in CBC report?

Kindly review my CBC report, which is showing high immature granulocytes.

The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

Dr. Chithranjali Ravichandran

Published At April 29, 2021
Reviewed AtApril 29, 2021

Patient's Query

Hi doctor,

I would like someone to review my CBC report. The report shows high immature granulocytes. This was a routine annual draw.


Welcome to icliniq.com.

From the reports (attachments removed to protect the patient's identity), there is a slight increase in the percentage of immunoglobulins is insignificant. The rest of your parameters are in range. Go ahead for vaccination.

Patient's Query

Hi doctor,

Thank you.

I am concerned because online information states that a healthy individual should not have these in blood and can be a sign of potential active infection or cancer. Should I be concerned? Does the % detail myeloblasts? Are these numbers raised because of the first vaccination?


Welcome back to icliniq.com.

You can rule out infections by ESR (erythrocyte sedimentation rate), CRP (C-reactive protein) tests.

The word leukemia means white blood cell cancer in peripheral blood. Leukemia is a relatively old term. Nowadays, it is called hematopoietic and lymphoid neoplasm. A good share of circulating white cells comes from lymphoid tissues such as lymph nodes, spleen, thymus, etc. And the rest of the cells come from bone marrow. Lymphoid tissue is present all over the body, even in the intestine, lungs, liver, etc. The neoplasms of lymphocyte's white blood cells are called lymphomas which are rarely present in the blood. They are present in lymphoid tissue. However, they do infiltrate blood and bone marrow at some later stages (stage 4 disease). Now, there are certain neoplasms arising from bone marrow. They are myeloid or lymphoid leukemias. They are most of the time present in peripheral blood. In addition, leukemia and lymphoma are not merely the presence of certain types of abnormal cells. It is a whole package comprising of anemia, leukopenia or leukocytosis, high ESR, thrombocytopenia, unexplained fever, weight loss, arthralgias, and myalgias, etc. These are diagnosed using FNAC (fine needle aspiration cytology), bone marrow biopsy, immunohistochemistry, flow cytometry, radiological surveying, etc. These are treated with chemotherapies selected according to the type of cells involved in lesions.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Mubashir Razzaq Khan
Dr. Mubashir Razzaq Khan


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