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What can be the reason behind the inability to get pregnant in a woman who has PCOS, low AMH, failed IVF, and a 22ps+ karyotyping report?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Answered by

Dr. Reetika

Medically reviewed by

iCliniq medical review team

Published At July 14, 2022
Reviewed AtDecember 6, 2023

Patient's Query

Hi,

I have not conceived in 11 years. I have PCOS and low AMH, and I had adhesiolysis surgery a few months before going for IVF. Currently on medicines like Inositol, Suresitol (one sachet daily), Femgold, Folcure-5, Metformin, supplements like multivitamins, vitamin D, biotin, omega 3, vitamin E, vitamin C, and coenzyme Q10. I am also trying to improve my lifestyle. I am looking for a second opinion on the treatment I am taking for infertility. I had one failed IVF-ICSI. Out of seven eggs, only two were fertilized. One stopped after fertilization another slowed down or stopped after three cells. My husband’s sperms were normal for the treatment, with DNA fragmentation around 19 % before IVF. After it failed, our doctor suggested doing a karyotyping test for both of us. My husband’s report was normal, but mine showed something like 46 XX and 22ps+. I want to know what does this karyotype result conclude? What are our chances of success if we go for another round of IVF? My karyotyping result might explain failed fertilization or embryo formation. Does this conclude my eggs are not viable at all? We cannot go for donor eggs or sperm due to personal reasons. I would highly appreciate your honest opinion on this. Thanks in advance.

Answered by Dr. Reetika

Hello,

Welcome to icliniq.com.

I read your query and understand your concern.

I have gone through the details presented by you.

The genetic aberration of 22ps+ is associated with reproductive dysfunction, including infertility, the possibility of sterility, recurrent abortion, etc.

You may consider the donor egg option.

Feel free to ask any questions or to share any additional information.

Thank you.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Reetika
Dr. Reetika

Obstetrics and Gynecology

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