Q. I have low neutrophil count with occasional low-grade fever, joint pain and fatigue. Why?

Answered by
Dr. Vandana Andrews
and medically reviewed by Dr. Vinodhini. J
This is a premium question & answer published on Jun 29, 2020 and last reviewed on: Dec 27, 2022

Hello doctor,

I am a 24-year-old female. I have done my blood work and the neutrophil count is very low 0.6 from normal in a matter of weeks and I do not understand why. Other symptoms, I am having are low-grade fever, joint pain (knees, hips, and shoulders), extreme fatigue, and spasms in my leg. All of these symptoms come and go, and not always all together. But I have periods where I feel good and manage to work out and do things I usually do and other periods where I am so tired and cannot do anything.



Welcome to

Your concerns are valid. The symptoms could be due to a condition called neutropenia (low neutrophil counts).

It is generally seen in conditions like infections viral, bacterial, or parasitic infections. Examples include HIV (human immunodeficiency virus), tuberculosis, malaria, Epstein-Barr virus (EBV), vitamin deficiencies (megaloblastic anemia due to vitamin B12 or folate deficiency), congenital (inborn) disorders of bone marrow function or neutrophil production (Kostmann syndrome), and hypersplenism which refers to the increased sequestration or destruction of blood cells by the spleen.

All these are common causes, which has to rule out for treating the cause. I hope you can find a doctor and start treating the cause for neutropenia. Medical management would differ from each of them, so it is important to find the cause, we may require more intent blood workup which can only be done at the doctor's office.

I hope this helps.

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