Q. Can nulliparity and endometriosis increase the chances of uterine cancer?

Answered by
Dr. Uzma Arqam
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Mar 15, 2023

Hello doctor,

I am a 52-year-old female, have had endometriosis my entire life, and have never been able to have a child. I have had ovarian cysts before, but they go away. However, I recently had a cyst on my left ovary, lower back, and groin pain, and my period has returned (my last period was five years back). Next week, I will have my left ovary removed and a D and C. Is this cyst causing my leg and foot to swell throughout the day? I am worried. Do I have a higher risk of ovarian cancer, and are cysts usually noncancerous? Please help.



Welcome to

I understand your concern.

Your history suggests that you should closely monitor your reproductive system to avoid future complications. Nulliparity (a woman who has never had a pregnancy), endometriosis, ovarian cysts, and left ovarian removal all increase the risk of female genital tract cancers or malignancy. The ovary is placed in the ovarian fossa. The nerve supplying this area can irritate the umbilical and upper medial thigh. You may experience pain in these areas if the ovary is involved in the early stages. Still, if ovarian pathology is already present, you may experience more advanced and prolonged pain. Kindly have a detailed scan and tumor marker CA 125 (cancer antigen) a screening test for ovarian cancer immediately. If this comes normal, even then, you need follow-up scans for ovarian cyst size and texture change and CA 125 again if the ultrasound shows changes. So please pay attention. Rescan and have CA 125 as well. I suggest you have the following examination:

1. Cervical smear.

2. High vaginal swab.

3. Hysteroscopic local examination.

4. Endometrial biopsy to rule out endometrial or cervical polyp and endometrial atypia.

Have the suggested laboratory test, and then discuss the results with your doctor or a local gynecologist. Engage recreational activities and refrain from using recreational drugs. Have complete treatment for any health issues you may have.

Thank you.

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