What are the alternatives of Levodopa in Parkinson's?

Hi,

Welcome to icliniq.com.

I want to assure you that you do not need to worry, as everything is going to be fine soon. I have thoroughly gone through your case and can well understand your genuine concerns. First thing is, unless the diagnosis is made by an expert physician, similar symptoms do not mean that you have Parkinson's disease. There are many other drugs that are to be used as an adjunct to the Levodopa and that show a good result in many patients. Such as Levodopa with Carbidopa (a peripheral decarboxylase inhibitor) is a good combination. Also, we have Ach-Acetylcholinesterase inhibitors, NMDA (N-Methyl-D-Aspartate) antagonists, COMT (catechol-O-methyl transferase) inhibitors, MAO-B (Monoamine oxidase-B) inhibitors, anticholinergics, etc. Your symptoms can also be due to other conditions, such as liver disease (hepatitis and cirrhosis), anemia, fluid and electrolyte imbalance, thyroid disease, and blood pressure issues. Please answer the mentioned questions for better diagnosis and treatment. What is your age, gender, height, weight, and waist circumference? What is your manganese level? If you have the laboratory reports, kindly upload them. Have you checked your pulse rate, blood pressure, and blood sugar level recently? Please send me all laboratory reports, MRI, CT, radiographs, etc., relevant to your query. You also need to do investigations for a comprehensive metabolic panel, liver viral markers for hepatitis B and hepatitis C, and thyroid profile. Differential diagnosis may include liver disease, anemia, thyroid disease, or diabetes. Treatment will be decided according to your laboratory reports. As there are many possibilities, we have to proceed with care.

I hope this helps.

Please feel free to reach out in case of further queries.

Thank you.

Hi,

Welcome back to icliniq.com.

I have thoroughly gone through your case and can well understand your genuine concerns (attachment removed to protect the patient's identity). Your main issue is dyslipidemia (deranged lipid profile). Over the last 4 years, in all laboratory reports, you have high bad cholesterol (LDL) and low good cholesterol (HDL). Whenever a patient presents with a complaint as you have and the lipid profile is the same as yours, then I usually prescribe him, first of all, to follow a diet and lifestyle modification. In the majority of patients, it works very well and gets the lipid under control. A very small number of patients need some medication for long-term use, such as Fenofibrate or Pravastatin. You need to lose some weight through diet control and exercise. All the symptoms you have are consistent with the diagnosis. Take Sea-Mega capsules and fatty fish in food (for example, herring fish). Avoid fat and carbohydrates in excess and say no to fried foods, fast food, energy drinks and beverages. Avoid red meat, chicken, alcohol and cigarettes. Avoid excess salt and sugar. Take plenty of water. Start proper physical activity and make it a habit. It will help you get HDL up, LDL and triglycerides low. After some weeks, come back to me with a fresh comprehensive metabolic panel, including fasting lipid profile, to see how you are doing, and I will be able to decide if you need medications to lower the levels.

I hope this helps.

Please feel free to reach out in case of further queries.

Thank you.