I have orthostatic intolerance, but my tilt-table test is negative for POTS. Kindly help me.

Hi,

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As per your description, your current medical concerns are autonomic dysfunction and hypothyroidism. Medications are Levothyroxine, dose unknown, Propranolol LA 60 mg once daily and Andrographis paniculata extract twice daily. The patient suffers from multiple symptoms, likely autonomic, associated with prolonged standing, which improve on sitting or lying down and are worse in summer. Attached is a picture that shows swelling in the leg (attachments removed to protect the patient's identity) and mottling, which is suggestive of venous stasis. There is no history of syncope (sudden onset transient loss of consciousness) mentioned. The patient has been on Propranolol LA for an unknown duration to which she has partially responded. In the past, she has been on Fludrocortisone for the same. She underwent a tilt-table test for evaluation for POTS (postural orthostatic tachycardia syndrome) which was negative for that diagnosis. Her HR (heart rate) increase was a maximum of 13 BPM (beats per minute) higher than baseline. I do not have a baseline ECG (electrocardiography). Based on that, my opinion is that, although there are some competing diagnosis, the symptoms are most likely due to orthostatic intolerance, which means problems of BP (blood pressure) and HR on standing up. A few blood tests to rule out any secondary condition will be required, if not already done. I will mention them in the recommendations. Now there are many conditions that can be associated with orthostatic intolerance. POTS is one of them. The other can be PSWT (postural symptoms without tachycardia). The treatment for both conditions remains the same as both are dysautonomia conditions of an autonomic nervous system disorder. I suggest following blood tests like CBC (complete blood count) and thyroid profile to rule out orthostatic intolerance due to secondary conditions. Repeat the tilt-table test with a longer propranolol break. Take non-pharmacological measures like increase water intake to three liters per day, increased salt intake up to 10 gm per day, monitor BP. Although uncomfortable, lower body compression garments such as waist-high-compression stockings or abdominal binders reduce venous pooling. An exercise program featuring aerobic training can improve symptoms with some additional leg resistance training. Regular exercise frequency (at least four days per week) with a session duration of at least 30 minutes must be followed. It can take four to six weeks for you to start to notice improvements. An exercise program using rowing machines, recumbent cycles, or swimming are often better tolerated than upright exercises in patients with POTS. Patients who neither have an increase in heart rate nor fall in BP but have orthostatic symptoms might benefit from medications like Methyldopa or Clonidine. However, as mentioned previously, a repeat tilt table test is needed, non-pharmacological measures shall be tried first, and the medicines have to be taken only after being prescribed by your physician and under their guidance. I hope this was helpful.