HomeAnswersSexologysertralineI am taking Sertraline 100 mg. What are my possibilities of developing erectile dysfunction?

Do Sertraline tablets cause erectile dysfunction?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

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Published At June 29, 2023
Reviewed AtJune 29, 2023

Patient's Query

Hello doctor,

I have been taking Sertraline for a good few years and have found that 100 mg works best for me. I have heard stories that people experience sexual problems, such as erectile dysfunction, with medication. If I have not had any symptoms of this. How likely is it that it will happen from taking Sertraline? Also, when people stop taking Sertraline, they can still experience ongoing sexual symptoms. What is the reason for this?

Thank you.

Hello,

Welcome to icliniq.com.

I read your query and can understand your concern.

If you have been taking Sertraline for several years and have not developed erectile dysfunction yet, then it is unlikely that you will experience it now. Sertraline may cause erectile dysfunction in some people, but not all. If it does happen, it usually occurs within a year or two. Neurotransmitters act differently in different people. People who take it for sexual problems may still experience those problems after stopping the medication.

You can reconnect for further queries.

Thank you.

Patient's Query

Hello doctor,

Thank you for your quick response.

I have not experienced any sexual side effects on doses of 50 mg or 150 mg in the past. Is erectile dysfunction more likely to occur during the first few months of getting used to the medication, or can people be fine initially and then develop symptoms a year or two after taking it? Also, if I safely lower my dose and come off the medication, is there a risk of the changing chemicals causing erectile dysfunction in the months after?

Thank you.

Hello,

Welcome back to icliniq.com.

I understand your concern.

People who develop erectile dysfunction from Sertraline usually do so after three to four months of use, although it may rarely develop up to a year or two later. It is unusual to experience erectile dysfunction in the months following the discontinuation of Sertraline. The medication increases the level of serotonin, which can slow down sexual response and lead to erectile dysfunction. However, this effect can be useful for premature ejaculation. It is an antidepressant, so in depressed people, it improves sexual function if the cause of sexual dysfunction is psychological.

Hope this information helps you.

Thank you.

Patient's Query

Hello doctor,

Thanks again. I took Sertraline for around three years, stopped taking it for around one year, and now have been taking it again for around eight months. I have had no effects of erectile dysfunction again. Do I need to wait up to a year or two again before finding out if it will happen again? Or will my body respond to the tablet the same as last time?

Hello,

Welcome back to icliniq.com.

You need to wait for a year or two because you are not a first-time user. You have taken Sertraline earlier too. But one thing is not clear to me, the reason for you taking Sertraline. If you are taking it for depression or anxiety, then it may be helpful for your sexual function. If taken for erectile dysfunction, then it is not the proper antidepressant. In my experience, the same medicine taken the second time may not have similar effects as the first time in some individuals. It all depends on how the body adjusts to the medicine. And it is an individual phenomenon that cannot be generalized.

Hope this helps.

Regards.

Patient's Query

Hello doctor,

Thanks for the reply. I take Sertraline for OCD. I especially worry about things that may happen outside of my control. One article said that even coming off Sertraline, it can be hard to change the chemical effects, and you can be affected for years. Also, even when people have had no side effects at the time, they have come off Sertraline and had sexual problems from it. In all these years, I have never had erectile dysfunction, but it worried me that I would suddenly have it and that there was nothing I could do to stop it.

Hello,

Welcome back to icliniq.com.

You are taking Sertraline for OCD (obsessive-compulsive disorder). And you have not developed erectile dysfunction (ED). Your concern is about the article you read. Since you have not developed ED until now, you will not develop it later. I have seen patients taking high doses of SSRI (selective serotonin reuptake inhibitors) drugs without having any ED as a side effect. So relax, forget the article. Furthermore, if by chance you have ED, then most likely it would be due to your mind being influenced by the article, and there are medicines like Bupropion that can reverse ED caused by SSRI.

Hope this helps.

Revert in case of queries.

Regards.

Patient's Query

Hello doctor,

Thanks for the information.

One of the articles I read was about SSRI syndrome. It had very little information on it. I did not know its cause and said the damage could be permanent. I think that is what scared me. I guess they meant a medication like Bupropion would help? What do you know about the syndrome?

Hello,

Welcome back to icliniq.com.

Medicines like Bupropion can reverse ED caused by SSRI.

Revert in case of queries.

Regards.

Patient's Query

Hello doctor,

Thanks again. This will be my last question, as I am aware I have some reassurance-seeking going on. Is this different from post-sexual dysfunction (PSSD)? That seems to really affect people's sexual health. I will look to accept that I have been on Sertraline for a long time and will not have any negative ED effects.

Hello,

Welcome back to icliniq.com.

PSSD is post-SSRI sexual dysfunction. But you have not developed sexual dysfunction. So you do not fall under the category of PSSD.

Hope this helps.

Regards.

Patient's Query

Hello doctor,

I am sorry to say that I am still struggling and feeling really stuck. I looked back and took Sertraline at different levels (50mg, 100mg, and 150mg) for a total of 3 and a half years, before having a 10-month break and now I have been back on Sertraline (50 mg then 100 mg for 14 months). I am still thinking about the 1 to 2 years of people getting potentially erectile dysfunction and if you are therefore safe from it being an effect of Sertraline after that.

I worry about my body reacting differently to the tablet after all these years and the neurotransmitters (Dopamine), testosterone, and enzymes and receptors being unable to cope. Could my body now suddenly reject the pill and will l start having ED? I worry about eventually coming off the tablet and my body struggling with this even though I came off for 10 months and had no sexual side effects.

Thank you.

Hello,

Welcome back to icliniq.com.

You have not developed erectile dysfunction while on or off Sertraline. So you are not going to develop in the future any ED related to Sertraline. But your constant worries about ED might affect your sexual function. Relax and enjoy. Do some breathing exercises and walking. This will reduce your anxiety.

Thank you.

Patient's Query

Hello doctor,

What makes you certain that I would not develop erectile dysfunction in the future without Sertraline? Is there any scientific evidence that says after a certain amount of time you will get used to the tablet? Does the tablet always react the same in the body? I know it is different for each person so could my body act differently?

Thank you.

Hello,

Welcome back to icliniq.com.

Yes, your body could react differently. There is no science that says certainly you will not develop a problem. It is a common observation that if you have not developed a problem in 1 to 2 years it is unlikely you will develop it later. In the case of most medicines adverse effects usually develop within the initial period and if they persist then one has to stop it. But if the side effects do not persist it means the body has adjusted to the medicine. When the body adjusts it means he can continue the medicines. In some cases, higher doses are needed for the desired effects. Yes, each person may react differently.

Hope this helps. Thank you.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Purushottam Sah
Dr. Purushottam Sah

Obstetrics and Gynecology

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