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Anal Cancer - Types, Signs, Symptoms, Causes, and Treatment

Published on Jan 12, 2021 and last reviewed on Nov 19, 2021   -  5 min read


Anal cancer is a rare type of cancer found in the anal canal. Read about its types, signs, symptoms, causes, and treatment options.

Anal Cancer - Types, Signs, Symptoms, Causes, and Treatment

What Is Anal Cancer?

Anal cancer, otherwise called carcinoma of the anal canal, is a rare type of cancer found in the anal canal, the tube present at the end of the digestive tract through which feces leaves the body. When the cells that line the anal canal become abnormal, they can form benign (noncancerous) or malignant (cancerous) tumors in the anus, resulting in anal cancer. This rare tumor can spread to other parts of the body, and a few noncancerous anal tumors can turn cancerous over time. Almost 50 % of all cases of anal cancers are diagnosed before cancer cells spread beyond the initial site. In 13 to 25%, it is diagnosed after cancer cells spread to the lymph nodes, and in 10%, after cancer cells have traveled to distant organs. Anal pain and rectal bleeding are common symptoms associated with this type of cancer.

When diagnosed early, anal cancer is highly treatable. The anus is lined by tissue from the skin and intestine. The most common type of anal carcinoma is SSC or squamous cell carcinoma, a type of skin cancer. The treatment is usually done with a combination of chemotherapy and radiation therapy. Combining two or three treatment options increases the chance of a cure, but it also increases the incidence of side effects. The five-year survival rate of people diagnosed with anal cancer is 67%.

What Are the Types of Anal Cancer?

The following are some common types of anal cancer:

  1. Benign Anal Growths - Bening or noncancerous growths in the anus like skin tags, polyps, genital warts, and granular cell tumors.

  2. Precancerous Lesions in the Anus - Benign growths that are capable of turning malignant over time. Examples include anal squamous intraepithelial neoplasia (ASIL) and anal intraepithelial neoplasia (AIN).

  3. Squamous Cell Carcinoma - As mentioned before, it is the most common type of anal cancer. These are cancerous or malignant tumors in the anus that originate from abnormal squamous cells.

  4. Squamous Cell Carcinoma In Situ - Otherwise called Bowen’s disease. Here, abnormal squamous cells are seen on the surface of the anal canal and not in the deeper layers.

  5. Adenocarcinoma - Another rare type of anal cancer that originated from the glands present around the anus.

  6. Basal Cell Carcinoma - It is also a type of skin cancer that forms in the skin exposed to the sun. It is a rare form of anal cancer.

What Are the Signs and Symptoms of Anal Cancer?

The possible signs and symptoms of anal cancer are:

A few people with anal cancer do not experience any symptoms. These symptoms are not specific, and the chances of anal cancer are significantly less, even if you have these symptoms. Piles or hemorrhoids and anal fissures can result in similar signs and symptoms.

What Are the Causes of Anal Cancer?

Scientists believe that infection with the human papillomavirus (HPV) is linked to anal cancer. But, this does not mean that getting infected with HPV will definitely lead to anal cancer. HPV infection, along with other risk factors, are believed to trigger the growth of anal cancer. Certain risk factors turn healthy cells in the anal canal abnormal. These abnormal cells, unlike the healthy cells, do not grow and multiply at a set rate and die eventually, but multiply out of control and keep accumulating. The abnormal cells can also go deeper and invade nearby tissues and distant organs.

Who Is at Risk of Developing Anal Cancer?

Women are more at risk of developing anal cancer than men. About 1 in 500 to 600 people are affected by this cancer. There are various factors that increase the risk of a person developing anal cancer. The following individuals are more prone to anal cancer:

  1. People who are 50 years or older.

  2. Those who have multiple sexual partners in their lifetime.

  3. Those who receive anal sex.

  4. Smokers.

  5. Those with a history of cervical, vulvar, or vaginal cancer.

  6. HPV infection increases not only the risk of anal cancer, but also cervical cancer. This virus is transmitted sexually and can result in genital warts.

  7. Having an anal fistula, an abnormal opening present between the anus and the surrounding skin.

  8. Organ transplant patients, as they take immunosuppressive drugs to prevent organ rejection.

  9. HIV (human immunodeficiency virus) infection, as it suppresses the immune system.

How Is Anal Cancer Diagnosed?

The doctor might conduct the following tests and procedures to diagnose anal cancer:

Once these tests show you have an abnormal growth or tumor in the anus, the doctor will suggest getting computerized tomography (CT), magnetic resonance imaging (MRI), or positron emission tomography (PET) to assess if the cancer cells have spread to the surrounding lymph nodes or distant organs.

What Are the Treatment Options for Anal Cancer?

Based on your age and how advanced the cancer is, the treatment options include:

1) Chemotherapy - These drugs are used to kill and prevent cancer cells from growing. It can be taken orally or directly injected into the veins.

2) Radiation Therapy - High-energy X-rays are also commonly used to kill cells of anal cancer. It is a non-invasive treatment option and is used along with chemotherapy or surgery.

3) Surgery - Tumor in the anus that has not spread to nearby structures is usually treated surgically through local resection surgery. Here, the tumor, along with some healthy tissue surrounding it, is removed. This surgery is done if the tumor is diagnosed during the early stages. Abdominoperineal (AP) resection, a more invasive surgery, is done in late-stage anal cancers where other treatment options did not help much. Here, the anus, rectum, and parts of the colon are removed.


The following tips might reduce your risk of anal cancer:

  1. Avoid or quit smoking.

  2. Use condoms and practice safe sex.

  3. Get vaccinated against the human papillomavirus (HPV).

Most people diagnosed with anal cancer live long and healthy lives. Early diagnosis is vital for this. The five-year survival rate for patients with anal cancer is 67 %, and localized anal cancers have a survival rate of 81.3 %. For more information, consult a surgical gastrologist or oncologist online.

Frequently Asked Questions


What Are the Causes of Anal Cancer?

The causes for anal cancer are:
- Anal sex.
- Multiple sexual partners.
- Drugs that suppress the immune system.
- History of cancer.
- Smoking.
- Human papillomavirus (HPV).


Is Anal Cancer a Common Condition?

Anal cancer is a rare condition. It is more common in males. Homosexual men are most commonly affected. Human papillomavirus can also cause anal cancer. The occurrence of sexually transmitted diseases is greatly noted in these patients, along with anal cancer.


How Does Anal Cancer Feel Like?

Anal cancer causes pain in the anus. Some patients might also feel pressure in the involved site. Alterations in the bowel movements are also noted. Itching sensation and discharge is seen in a few patients.


Is Anal Cancer a Painful Condition?

Yes, anal cancer can be very painful. Pain increases when a person is passing stools. In some patients, even bleeding might be seen. The treatment requires both radiation therapy and chemotherapy.


Can Anal Sex Increase the Risk of Anal Cancer?

Yes, anal sex might increase the risk of anal cancer. Involving in multiple sexual relationships can make a person more susceptible to infections like human papillomavirus or human immunodeficiency virus (HIV). Anal sex can serve as a risk factor for both males and females.


Can a Lump Near the Anus Indicate Cancer?

Not all lumps in the anus are cancerous conditions. Sometimes due to hemorrhoids, a lump can be seen near the anus. Certain specific diagnostic tools and blood examination might be required to make a confirmatory diagnosis for anal cancer.


What Are the Signs and Symptoms of Anal Cancer?

The signs and symptoms of anal cancer include:
- Pain in the anus area.
- Bleeding from the rectum or anus.
- Anal itching.
- Presence of mass or lump near the anus.
- Alterations in the bowel movements.
- Loss of bowel control.
- Inflammation of the lymph nodes near the groin.


Who Should Be Screened for Anal Cancer?

There are no particular medical guidelines for anal cancer. If you suspect yourself of any sexually transmitted infection, then you can proceed to consult with your doctor for a diagnosis. Screening is recommended more for men who are homosexuals.


What Is the Difference Between Cancer Tumors and Piles in the Anus?

Piles are referred to as the hemorrhoids that are found near the anal canal. It is very easy to cure with minimum treatment options. Anal cancer is a deadly condition and requires treatment for both the cancer tissue along with the organ it has spread.


Is It Possible to Cure Anal Cancer?

Yes, if anal cancer is detected in an early stage, it is possible to cure anal cancer. The problem with anal cancer is the spreading of the condition to the lungs, liver, and bones. The initial treatment method is aimed at controlling the severe effects of the condition.


How Is Anal Cancer Diagnosed?

Diagnosis for anal cancer requires rectal examination. In some patients, an instrument called an anoscope is used to conduct the inspection of the anus. To visualize the tumors in the anus, an ultrasound procedure might be required. In addition to this, CT and MRI scans might be recommended by the doctor.


What Is the Survival Rate for Anal Cancer?

The survival rate of anal cancer is estimated to be five years. The survival rate might depend on age and several other factors. With proper treatment options, it is possible to provide the cure for the patients.

Article Resources

Last reviewed at:
19 Nov 2021  -  5 min read




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