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Baricitinib - Dosages, Precautions and Side Effects

Published on May 16, 2022   -  5 min read

Abstract

Baricitinib (Olumiant) is used to treat rheumatoid arthritis and is also being considered for coronavirus treatment. Read the article to know more.

Contents

What Is Baricitinib?

Baricitinib is a Janus kinase inhibitor that is used to relieve pain, stiffness, and joint swelling in individuals with rheumatoid arthritis when all other treatment methods have failed. Baricitinib also has the additional benefit of slowing the course of bone and joint damage. Baricitinib is also being investigated for its potential application in the treatment of coronavirus. The Food and Drug Administration (FDA) of the United States has approved the emergency use of Baricitinib for the treatment of COVID-19 in adults and children over the age of two who are hospitalized and are on supplemental oxygen or a ventilator due to the illness. The use of Baricitinib to treat coronavirus or COVID-19 has not yet been approved.

How Should You Take Baricinitib?

What Role Does Baricitinib Play in the Treatment of COVID-19?

Baricitinib is a Janus kinase inhibitor that inhibits the activity of one or more members of a specific family of enzymes, hence interfering with the inflammatory pathway. The FDA approved the emergency use of Baricitinib in combination with Remdesivir for the treatment of certain hospitalized patients with suspected or confirmed COVID-19 infection. It also increases lymphocyte count and inhibits virus penetration into cells. Patients in the adaptive COVID-19 treatment trial-2 (ACTT-2) were given either Baricitinib or a placebo. Both groups got Remdesivir. Compared to Remdesivir plus Placebo, the combination of Baricitinib with Remdesivir showed speedy recovery and improved the clinical status of patients. The FDA has authorized its emergency use (EUA) for COVID-19 treatment.

1. Adults With Rheumatoid Arthritis: Used in adult patients with moderate to severe active rheumatoid arthritis who have not responded to one or more tumor necrosis factor (TNF) antagonists.

2. Adults with COVID-19 Infection: Used with Remdesivir to treat COVID-19 in hospitalized patients requiring supplementary oxygen, invasive mechanical ventilation, or ECMO (extracorporeal membrane oxygenation).

3. Pediatric COVID-19 Patients: Its use is recommended only for research purposes in the pediatric population.

What Are the Precautions to Be Taken Before Taking Baricitinib?

In combination with other medications, Baricitinib may increase your chance of developing life-threatening medical problems such as major infections, a hole or rip in your digestive tract, a heart attack or stroke, blood clots, or cancer. Inform your doctor if you have had any of the following:

What to Do in Case of a Missed Dose?

If you forget a dose, take the medication as soon as possible. Skip the missed dose if it is already time for your next dose. Do not double up the doses to compensate.

What Are the Side Effects of Taking Barcitinib?

What Are the Drug Interactions of Baricitinib?

There are 384 drugs known to interact with Baricitinib, 259 of which are major, 119 of which are moderate, and 6 of which are minor. This list does not include all possible drug interactions. Several drugs may interact with one another, including some of the following:

Conclusion:

All the information regarding this drug Baricitnib is for educational purposes and based on general information. The drug interactions and complications may vary depending on one’s health-related issues and conditions. Consult your healthcare practitioner to check that the information in this article applies to your specific situation. For further information and assistance, please contact our icliniq specialists.

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Last reviewed at:
16 May 2022  -  5 min read

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