HomeHealth articlesdepressionWhat Is the Link Between Birth Control Pills and Depression?

Birth Control Pills and Depression - Understanding the Effects of Hormones on Mood

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Birth control pills are one of the most common methods of contraception. Research says it may cause depression in some people. Read the article to know more.

Medically reviewed by

Dr. Kaushal Bhavsar

Published At December 12, 2023
Reviewed AtDecember 12, 2023

Introduction

One of the most widely used birth control methods is the pill, usually referred to as an oral contraceptive. They are practical, accessible, and efficient. However, over time, there has been an increase in worry about the connection between birth control pills and depression.

What Are Birth Control Pills?

Oral contraceptives, sometimes known as birth control pills, are drugs that must be taken orally in order to prevent pregnancy. They contain synthetic versions of the hormones estrogen and progesterone, which are similar to the hormones produced naturally by the ovaries.

Mechanism of Action:

The primary mechanism of action of birth control pills is to inhibit ovulation, thereby preventing the release of an egg from the ovaries. This prevents fertilization by sperm and, thus, pregnancy.

Additionally, the thickening of cervical mucus caused by birth control pills makes it more difficult for sperm to enter the uterus.

Types of Birth Control Pills:

There are two main types of birth control pills:

Combination pills contain estrogen and progestin, while progestin-only pills only contain progestin.

Combination Pills:

Combination pills come in different formulations and can contain varying doses of estrogen and progesterone. They are typically taken for 21 days, followed by a seven-day break, during which time menstruation occurs. Some combination pills are taken continuously, without a break, to prevent periods altogether.

Progestin-Only Pills:

Progestin-only pills are taken every day without a break. They are often used by women who cannot tolerate estrogen, such as those who are breastfeeding or have a history of blood clots.

Uses of Birth Control Pills:

The primary use of birth control pills is to prevent pregnancy. However, they are also used for other purposes, such as:

1. Regulating Menstrual Cycles: Birth control pills can help regulate menstrual cycles, making them more predictable and less painful.

2. Treating Acne: Certain types of birth control pills, particularly those containing the progestin drospirenone, have improved acne in some women.

3. Treating Symptoms of Polycystic Ovary Syndrome (PCOS): Birth control pills can help to regulate menstrual cycles and treat polycystic ovarian syndrome (PCOS) symptoms like acne and excessive hair growth.

4. Reducing the Risk of Ovarian and Endometrial Cancer: Prolonged usage of birth control pills has been shown to lower the incidence of endometrial and ovarian cancer over time.

Side Effects:

Despite being largely regarded as safe and effective, birth control tablets can have certain unwanted effects, including:

  • Nausea and vomiting.

  • Headaches.

  • Weight gain.

  • Breast tenderness.

  • Mood changes, including depression and anxiety.

  • Irregular bleeding.

The use of birth control pills may increase the risk of blood clots, especially in women who smoke or have other risk factors for blood clot formation.

How Do Birth Control Pills Cause Depression?

The birth control pill's primary purpose is to prevent pregnancy, but it can also affect mood and emotional health. While taking the birth control pill, some women claim to have unpleasant side effects like mood swings, anger, and sadness. Although the precise mechanisms underlying the link between the birth control pill and mood are not entirely known, it is thought that the hormonal changes brought on by taking the pill are to blame.

One theory is that the synthetic hormones in the birth control pill can disrupt the natural balance of hormones in the body, leading to mood changes and other negative side effects.

Certain types of birth control pills, which contain higher levels of progestin, have been associated with a potentially increased risk of mood disorders, including depression.

It is thought that the normal hormonal changes experienced during the menstrual cycle have an effect on mental health. Birth control pill use, which controls hormone levels, has the potential to interfere with these normal hormonal shifts and affect mental health. In addition, the stress of remembering to take the pill every day at the same time can also be a source of stress and anxiety for some women, which can contribute to mood changes.

Further, estrogen and progesterone are the two specific hormones present in birth control pills in the synthetic form. They play an important role in regulating various physiological processes in the body, including mood.

Both hormones fluctuate throughout the menstrual cycle, and changes in their levels have been shown to impact mood and emotional well-being.

Estrogen:

  • Estrogen has been associated with positive effects on mood and cognitive function in women. Some studies have suggested that estrogen may help improve symptoms of depression and anxiety.

  • Estrogen plays a role in modulating neurotransmitter levels in the brain, including serotonin and dopamine. These neurotransmitters are involved in the regulation of mood, emotions, and motivation. The influence of estrogen on neurotransmitter activity can contribute to its potential impact on mood and mental well-being.

  • Estrogen also influences the levels of cortisol, a stress hormone, and can help regulate the body's response to stress.

  • Some birth control pills contain lower estrogen levels than others, and the amount of estrogen present in a pill can affect how it affects mood. Higher estrogen levels may have a greater positive effect on mood than lower levels.

Progesterone:

  • Progesterone can have both positive and negative effects on mood, depending on the dose and timing of its administration. In general, progesterone is thought to have a sedative effect and can cause feelings of fatigue, lethargy, and decreased motivation.

  • Progesterone can also affect the levels of neurotransmitters in the brain, including GABA and glutamate, which can influence mood and anxiety levels.

  • Some birth control tablets don't contain estrogen; instead, they only contain progestin, a synthetic version of progesterone. These pills are known as progestin-only pills and are often prescribed for women who cannot take estrogen-containing pills due to medical reasons.

  • Progestin-only pills have been associated with a higher risk of depression and other negative mood symptoms compared to combination pills that contain both estrogen and progestin.

What Are the Other Alternatives for Birth Control?

There are several non-hormonal birth control options available that do not have the potential to cause depression or other negative mood symptoms. Here are some examples:

1. Barrier Methods: Barrier methods, such as condoms or diaphragms, physically block sperm from reaching the egg and do not contain hormones. They can be effective when used correctly and consistently.

2. Copper Intrauterine Device (IUD): The copper IUD is a small, T-shaped device that is inserted into the uterus and can provide long-lasting contraception for up to 10 years. It does not contain hormones and is highly effective at preventing pregnancy.

3. Natural Family Planning: Also known as the fertility awareness method, natural family planning involves tracking a woman's menstrual cycle and avoiding sexual intercourse during the fertile window when pregnancy is most likely. It does not involve the use of hormones or devices.

4. Sterilization: Sterilization procedures, such as tubal ligation or vasectomy, provide permanent contraception and do not involve using hormones.

Conclusion

In conclusion, while some studies suggest a link between birth control pills and depression, the exact nature of the relationship remains unclear. The synthetic hormones estrogen and progesterone present in birth control pills can affect mood and emotional well-being in various ways, but the effects can be complex and are influenced by individual factors.

It is essential for women to have open and honest discussions with their healthcare providers regarding any concerns or questions they may have about birth control pills. Healthcare providers are knowledgeable about the various methods of contraception and can offer guidance in selecting a safe and effective option based on individual health needs and preferences. Not all women who use birth control pills experience negative side effects, but for those who do, the effects can be significant and may lead to the discontinuation of birth control pills. The choice to utilize birth control pills or any other form of contraception should be made in collaboration with a healthcare provider, considering individual needs and preferences.

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Dr. Kaushal Bhavsar
Dr. Kaushal Bhavsar

Pulmonology (Asthma Doctors)

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