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Relation Between Helicobacter Infection and Cardiovascular Diseases

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Helicobacter pylori is a bacteria that resides in the stomach, and infections caused by it can increase the risk of cardiovascular (heart) diseases.

Medically reviewed by

Dr. Yash Kathuria

Published At July 20, 2023
Reviewed AtJuly 20, 2023

Introduction:

Cardiovascular diseases are one of the leading causes of death worldwide. There are numerous risk factors associated with heart conditions and disorders. Helicobacter pylori infection is one of them. Helicobacter pylori is a bacterium that infects the lining of the stomach. Most people are infected with this bacterium, and most of them could be at risk of developing heart disease in the near future.

What Is a Helicobacter Pylori Bacteria?

Helicobacter pylori bacteria, commonly known as H. pylori, are spiral-shaped bacteria that can cause various digestive tract infections. These bacteria primarily reside in the stomach and small intestine of humans, and they can cause chronic gastritis, peptic ulcers, and even stomach cancer. H. pylori infections are usually acquired during childhood and can persist throughout a person's life if left untreated. The bacteria spread through–

  • Contaminated food or water,

  • Through contact with fecal matter from an infected person.

  • Mouth-to-mouth contact.

How Are Helicobacter Pylori Infections Diagnosed?

Diagnosis of H. pylori infections can be made using various methods such as–

  • Blood tests.

  • Respiratory tests.

  • Stool tests.

  • Endoscopy.

What is Helicobacter Pylori Infection?

Infection caused by the bacteria is known as an H. Pylori infection affecting the gut. The bacteria in the contaminated food and water is responsible for stomach infection and can lead to serious consequences. The bacterium can survive in the stomach for years without causing any symptoms. However, in some cases, it can cause various gastrointestinal symptoms such as abdominal pain, loss of appetite, bloating, vomiting, and nausea. Helicobacter pylori infection is diagnosed through a breath test, stool test, or a biopsy of the stomach lining.

What Are Cardiac Diseases?

Cardiac diseases are a group of diseases that affect the heart and the blood vessels. Disorders and diseases of the heart include mild conditions like arrhythmia to severe and fatal conditions such as heart attack and heart failure. Cardiac diseases can be caused by various factors such as:

  • Smoking.

  • High blood pressure.

  • High cholesterol.

  • Diabetes.

The symptoms of cardiac diseases can vary depending on the type of disease. However, common symptoms include chest pain, shortness of breath, and fatigue.

Surveys and scientific data suggest that there is a link between Helicobacter pylori infection and cardiac diseases. The bacterium can cause chronic inflammation in the stomach lining, which can lead to the release of various inflammatory markers in the blood. These inflammatory markers can cause damage to the blood vessels and the heart, leading to the development of cardiac diseases. Moreover, Helicobacter pylori infection has been found to be associated with an increased risk of blockages in the heart (atherosclerosis).

Chronic H. pylori infection results in a disturbed immune response, which ultimately contributes to cardiovascular abnormalities, including coronary artery diseases. Studies show individuals with Helicobacter pylori infection had a double risk of developing cardiac diseases compared to those without the infection. Another study found that treatment of Helicobacter pylori infection in patients with acute coronary syndrome reduced the risk of recurrent cardiovascular events.

How Does Helicobacter Pylori Infection Cause Heart Disease?

Helicobacter pylori has been recently found to be a causative factor for heart disease. Medical professionals discovered H. pylori antibodies in the blood of patients with cardiovascular complications. This bacteria lives in the epithelial cells of gastrointestinal organs and cause digestive complications. This provokes an inflammatory reaction and stimulates an immune response that further causes significant imbalances in various factors like cytokines, fibrinogen, triglycerides, high-density lipoprotein, C-reactive protein, heat shock protein, and white blood cell count, and provokes a number of problems such as atherosclerosis (thickening and hardening of arteries caused by plaque buildup) and blockages in the arteries supplying the heart (prothrombic state), and cross-reactivity which eventually leads to heart diseases. The bacteria H. pylori release toxigenic nutrients, leading to the formation of cholesterol patches in arteries and the onset of autoimmune disorders.

What Are the Risk Factors and Symptoms of Helicobacter Pylori Infection?

The risk factors for Helicobacter pylori infection include living in a developing country, poor sanitation, and crowded living conditions. Moreover, individuals who have a family history of Helicobacter pylori infection are at an increased risk of developing the infection. The symptoms of Helicobacter pylori infection can vary from person to person; however, common symptoms include–

  • Mild to severe abdominal pain.

  • Feeling bloated and gassy most often.

  • Nausea.

  • Vomiting.

What Are the Preventive Measures?

Preventive measures for Helicobacter pylori infection include practicing good hygiene, washing hands before meals, and avoiding contaminated food and water. Moreover, vaccination against Helicobacter pylori infection is being researched as a potential preventive measure. Preventive measures for cardiac diseases include maintaining a healthy diet, quitting smoking, and engaging in regular physical activity. People who have close contact with someone diagnosed with an H. pylori infection should also get tested for the bacteria to prevent further spread. Overall, early diagnosis and treatment of H. pylori infections can prevent serious complications such as stomach cancer and improve a person's quality of life.

What Is the Treatment for Helicobacter Pylori Infection and Cardiac Diseases?

The treatment of Helicobacter pylori infection involves a combination of antibiotics to eliminate the infection and proton pump inhibitors (for reducing gastrointestinal symptoms). Treatment of H. pylori infections typically involves a combination of antibiotics and acid-suppressing medications. The antibiotics kill the bacteria, while the acid-suppressing medications reduce the acidity levels in the gut. This allows the healing of the ulcers. The antibiotic course should be completed as prescribed by a doctor to prevent antibiotic resistance. The treatment of cardiac diseases depends on the type and severity of the disease. Treatment options include medication, lifestyle changes, and surgery.

Conclusion:

In conclusion, Helicobacter pylori infection has been found to be linked with an increased risk of cardiac diseases. Therefore, one needs to be aware of the potential link between the two. One should practice preventive measures to avoid diseases of the heart in the near future. Early detection of Helicobacter pylori infection and cardiac diseases is crucial for effective treatment and prevention of complications. Regular health checkups and screening tests can help in early detection and treatment.

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Dr. Yash Kathuria
Dr. Yash Kathuria

Family Physician

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