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Triple Vessel Disease - Causes, Signs , and Management

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Triple vessel disease refers to blockages or narrowing in all three major coronary arteries that supply blood to the heart. Learn more in the article.

Medically reviewed by

Dr. Yash Kathuria

Published At March 31, 2023
Reviewed AtFebruary 28, 2024

Introduction:

The prevalence of triple vessel heart disease varies depending on the population being studied and the criteria used to define the condition. Generally, it is considered a relatively rare form of coronary artery disease (CAD), with estimates suggesting that it affects less than ten percent of people with CAD. However, it is associated with a higher morbidity and mortality risk than single or double-vessel disease. In addition, this condition affects both men and women and mostly occurs in men rather than women. One of the primary causes of death in most communities worldwide is coronary artery disease (CAD) and its consequences, such as myocardial infarction or heart failure. The most severe type of coronary atherosclerosis is known as a three-vessel disease (3VD).

What Is Triple Vessel Disease?

Severe coronary artery disease is called "triple vessel disease" (CAD). When the main blood arteries supplying the heart are compromised or ill, CAD can occur. The two main causes of CAD are inflammation and plaque (cholesterol deposition). Larger plaque deposits may drastically reduce or completely block blood flow to the heart, whereas smaller plaque deposits may not affect it. These obstructions could give a patient chest pain, breathlessness, or even a heart attack. While most cases of CAD may only adversely affect one of the major coronary arteries, triple vessel disease, as its name suggests, affects all three of the heart's major blood vessels (left anterior descending, left circumflex, right coronary artery). In addition, the heart's left ventricle has decreased contractile function.

What Are the Causative Factors of Triple Vessel Heart Disease?

Atherosclerosis and hypertension are the most frequent causes of triple vessel heart disease (TVHD). Plaque, a collection of fatty deposits, calcium, and other substances, narrows or blocks the arteries in atherosclerosis. High blood pressure, or hypertension, can harm coronary arteries and result in triple vessel heart disease. Smoking, diabetes, high cholesterol, and a family history of heart disease are additional risk factors for triple vessel heart disease.

What Are the Signs of Triple Vessel Disease?

The signs of triple vessel disease mirror those of coronary artery disease:

  • Severe chest pain.

  • Shortness of breath.

  • Weakness.

  • Confusion.

  • Heartburn sensation.

  • Choking sensation.

  • Nausea and vomiting.

  • The back, jaw, neck, arms, or shoulders are among the upper body parts that can experience pain or discomfort.

  • Dizziness.

  • Light-headedness.

  • Rapid heartbeat.

  • Patients with blockages in other bodily arteries could also feel discomfort or muscular weakness.

What Are the Diagnostic Tests for Triple Vessel Heart Disease?

Several diagnostic tests can be used to detect triple vessel heart disease, including:

  • Coronary Angiography:

An invasive test that uses X-ray imaging to visualize the coronary arteries and detect any blockages or narrowing.

A non-invasive test that uses X-ray imaging to create detailed images of the heart and blood vessels.

  • Stress Test:

A non-invasive test involving exercising on a treadmill or stationary bike while monitoring heart function to detect abnormalities.

  • Echocardiography:

A non-invasive test that uses ultrasound waves creates images of the heart and detects any structural abnormalities or blood flow problems.

  • Nuclear Stress Test:

A non-invasive test includes injecting a small quantity of radioactive material into the bloodstream, followed by a stress test to look for variations in the heart's blood flow.

  • Blood Test:

Blood tests such as Troponin and CK MB (a cardiac marker that can help diagnose myocardial ischemia) can help detect a heart attack.

Ultimately, the choice of diagnostic test will depend on the individual patient's medical history and symptoms. The doctor can help them determine which test is best for them.

What Is the Purpose of Coronary Flow Reserve in Triple Vessel Heart Disease?

Coronary flow reserve (CFR) is a measure of the ability of the coronary arteries to increase blood flow in response to increased demand, such as during exercise. In patients with triple vessel heart disease, which is the presence of blockages in three coronary arteries, a decreased CFR can indicate that the heart is not receiving enough blood flow to meet its increased demands. This results in severe chest pain and breathing issues and increases the risk of serious complications such as heart attacks. In addition, a decreased CFR in patients with triple vessel heart disease often indicates further intervention, such as angioplasty or bypass surgery.

What Is the Treatment of Triple Vessel Heart Disease?

Treatment for triple vessel heart disease, also known as triple vessel coronary artery disease, typically involves a combination of lifestyle changes, medications, and procedures.

  • Lifestyle Modifications:

It may be advised to make lifestyle adjustments such as giving up smoking, consuming a healthy diet, and exercising frequently. These modifications may lessen the possibility of the heart and blood vessels suffering future harm.

  • Medications:

Medications, including aspirin, statins, beta-blockers, and ACE inhibitors, may be prescribed. These medications can help to lower cholesterol levels, reduce blood pressure, and improve blood flow to the heart.

Some procedures, such as angioplasty or bypass surgery, may also be recommended.

  • Angioplasty:

During an angioplasty, a tiny balloon is put into the constricted or blocked artery and inflated to enlarge the conduit.

  • Bypass Surgery:

Bypass surgery includes constructing a new artery to allow blood to pass through the obstructed one.

Working closely with a healthcare provider to develop an individualized treatment plan that considers the patient's specific needs and circumstances is important. In addition, regular follow-up appointments and monitoring are necessary to ensure the treatment's effectiveness and make any necessary adjustments. In addition, it is crucial to have a healthy lifestyle, stop smoking, and manage blood sugar levels if diabetic. These measures can slow the progression of the disease, improve the patient's quality of life, and reduce the risk of complications.

Conclusion:

Triple vessel heart disease is a serious condition that requires prompt diagnosis and treatment. A combination of lifestyle changes, medications, and procedures may be needed to manage the condition and reduce the risk of complications. In addition, regular monitoring is necessary to ensure the treatment's effectiveness and make any necessary adjustments. Therefore, it is essential to diagnose and provide immediate medical attention correctly.

Frequently Asked Questions

1.

How Severe Is Triple Vessel Disease?

Triple vessel disease is a severe form of coronary artery disease (CAD).  In this condition, all three main coronary arteries providing blood to the cardiac muscle are restricted or obstructed due to atherosclerosis (plaque formation). The severity of the triple vascular disease is determined by the degree of constriction or blockage in these arteries as well as the related symptoms.

2.

What Is the Overall Survival Rate for Triple Vessel Disease?

Individuals with triple vessel disease have a variable overall survival rate based on various factors, including the condition's severity, symptoms' existence, the success of medical treatment, and the person's general health. For triple vessel disease, the 5-year survival rate is 80.7%, and the 10-year survival rate is 64.2%.

3.

Can Angioplasty Be Used to Treat Triple Vessel Disease?

Yes, triple vessel disease can be treated with angioplasty. In selected individuals with triple-vessel coronary artery disease, triple-vessel angioplasty provides a safe and effective alternative to surgical revascularization.

4.

What Causes Triple Vessel Disease?

Atherosclerosis, the development of deposits of fat and plaque within the arteries that feed blood to the heart muscle, is the primary cause of triple vessel disease. The two main causes of coronary artery disease are plaque (cholesterol deposition) and inflammation. 

5.

Is It Possible to Reverse Triple Vessel Disease?

Advanced triple vessel disease is difficult to reverse fully. Still, several medical interventions, lifestyle changes, and medications can be used to delay its progression, relieve symptoms, and lower the risk of consequences.

6.

How Long Can Someone Survive With Three Blocked Arteries?

Once their arteries get clogged, there is no predetermined timeline for a person's lifespan. After the blockage is identified, medical procedures are available to improve blood flow and prevent further issues.

7.

What Is a Triple Vessel or Left Main Disease?

Triple vessel disease is characterized by blockages or narrowing of all three major coronary arteries, which carry blood to the heart. These arteries include the right coronary artery, the left circumflex artery, and the left anterior descending artery. 

8.

Is It Possible to Perform PCI for Triple Vessel Disease?

Yes, in certain situations, percutaneous coronary intervention (PCI), which involves angioplasty and stent implantation, can be used to treat triple vessel disease. Percutaneous coronary intervention (PCI) aims to provide a less intrusive, safer substitute to coronary artery bypass graft surgery.

9.

Can Angioplasty Be Used to Treat Triple Vessel Disease?

Yes, angioplasty can be used to treat triple vessel disease in some conditions. The practicality and success of angioplasty in treating triple vessel disease are dependent on a number of circumstances, including the size and severity of the blockages, the patient's overall health, and the presence of symptoms.

10.

Can Triple Vessel Disease Be Treated by Stenting?

Yes, stenting can be used to treat triple vessel disease. Stenting may be a better option than CABG (coronary artery bypass grafting) in a selected group of patients with multivessel coronary disease.
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Dr. Yash Kathuria
Dr. Yash Kathuria

Family Physician

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