Q. Can I opt biologic Etanercept for ankylosing spondylitis?

Answered by Dr. Ashaq Hussain Parrey and medically reviewed by Dr. Nithila A
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Hello doctor,

I have ankylosing spondylitis (HLA B27 positive) for the past 12 years and with pulmonary tuberculosis the very next year. And took medicine for nine months, and now I am daily taking Saaz, and I am going to plan for Biologics. The doctor suggested Etanercept 50 mg, but I am afraid of side effects as I was already affected by TB before 11 years. Shall I go for biologic Etanercept 50 mg, and what precautions I have to take during biologics? (I have enclosed the report)

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Dr. Ashaq Hussain Parrey

General Medicine Internal Medicine Rheumatology


Welcome to icliniq.com.

You need to do Mantoux test and interferon gamma level before starting biologics because they can cause reactivation of tuberculosis if there is doubt you should receive the two drug ATT regimen (anti-tubercular treatment) before starting biologics that is recommended if either Montoux or interferon gamma is positive.

Thank you doctor,

Mantoux test is positive PPD is 5 TU.

Dr. Ashaq Hussain Parrey

General Medicine Internal Medicine Rheumatology


Welcome back to icliniq.com.

Then better would take three months regimen for tuberculosis before starting ATT. You may not have tuberculosis, but prevention is always better than cure.

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