Published on Feb 22, 2017 and last reviewed on Sep 07, 2018 - 1 min read
Here, I have discussed about the mechanism of action and procedure details of autologous serum therapy.
The treatment of choice for chronic urticaria is the first generation antihistamines at a maximal dose before restoring to corticosteroids or Cyclosporine. To avoid the various side effects of steroids and expensiveness of Cyclosporine, there is a method with no side effects and cheap to prepare, known as autologous serum therapy. In this therapy, we inject patient's own blood repeatedly at weekly interval to treat chronic urticaria or can use whole blood as a part of treatment.
This therapy is very effective in the treatment of chronic urticaria. This procedure is also widely used in the treatment of various diseases like atopic dermatitis, allergies, chronic inflammation, vascular diseases, osteoarthritis and various other skin diseases.
Mechanism of Action:
AST - autologous serum therapy works on the principle of inducing desensitization or tolerization to pro-inflammatory signals expressed in patient's own circulation.
Instruments to Be Used in the Procedure:
In this therapy doctor always takes your written informed consent and he will collect your blood in red top vacutainer. Then, he centrifuges (spins) your blood at 3000 revolutions per minute for 10 minutes to separate serum. The freshly prepared serum will be separated in a 5 cc syringe. He will inject 2.5 mL of serum deep intramuscularly in gluteal muscles with the help of a 22 gauge needle at a weekly interval for 9 weeks. Later, it can be given fortnightly for maintenance therapy.
This therapy is gaining popularity, because of its cost effectiveness and not involving the use of various expensive drugs like biologics such as Omalizumab and Cyclosporine.
For further details about autologous serum therapy, consult an allergy specialist online --> https://www.icliniq.com/ask-a-doctor-online/allergy-specialist
Query: Hi doctor,I have been suffering from preliminary chronic urticaria for unknown causes for the last 13 years. It is not responding to antihistamine treatment for the past six years. Sometimes, it gets as severe as I have to use Corticosterone injection (Diprofos). All blood analysis showed no cause.¬... Read Full >>
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Article Overview: Urticaria is a condition that is characterized by the presence of wheels or hives over the body. Usually, it occurs alone but may also occur along with swelling of lips, eyes, and face (angioedema). Read Article
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