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Autologous Serum Therapy - a Newer Approach in Management of Chronic Urticaria

Written by
Dr. Suvash Sahu
and medically reviewed by iCliniq medical review team.

Published on Feb 22, 2017 and last reviewed on Sep 07, 2018   -  1 min read

Abstract

Abstract

Here, I have discussed about the mechanism of action and procedure details of autologous serum therapy.

Autologous Serum Therapy - a Newer Approach in Management of Chronic Urticaria

The treatment of choice for chronic urticaria is the first generation antihistamines at a maximal dose before restoring to corticosteroids or Cyclosporine. To avoid the various side effects of steroids and expensiveness of Cyclosporine, there is a method with no side effects and cheap to prepare, known as autologous serum therapy. In this therapy, we inject patient's own blood repeatedly at weekly interval to treat chronic urticaria or can use whole blood as a part of treatment.

This therapy is very effective in the treatment of chronic urticaria. This procedure is also widely used in the treatment of various diseases like atopic dermatitis, allergies, chronic inflammation, vascular diseases, osteoarthritis and various other skin diseases.

Mechanism of Action:

AST - autologous serum therapy works on the principle of inducing desensitization or tolerization to pro-inflammatory signals expressed in patient's own circulation.

Instruments to Be Used in the Procedure:

  1. Centrifuge digital machine.
  2. Syringe and needle.
  3. Vacutainers with 21 gauge needle.
  4. ASST (autologous serum skin test).

Procedure:

In this therapy doctor always takes your written informed consent and he will collect your blood in red top vacutainer. Then, he centrifuges (spins) your blood at 3000 revolutions per minute for 10 minutes to separate serum. The freshly prepared serum will be separated in a 5 cc syringe. He will inject 2.5 mL of serum deep intramuscularly in gluteal muscles with the help of a 22 gauge needle at a weekly interval for 9 weeks. Later, it can be given fortnightly for maintenance therapy.

This therapy is gaining popularity, because of its cost effectiveness and not involving the use of various expensive drugs like biologics such as Omalizumab and Cyclosporine.

For further details about autologous serum therapy, consult an allergy specialist online --> https://www.icliniq.com/ask-a-doctor-online/allergy-specialist

Last reviewed at:
07 Sep 2018  -  1 min read

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