My blood group is positive and my fiance's is negative. What problem do we need to face?

Hi,

Welcome to icliniq.com.

I can understand your concern.

From history, I hope you are saying that you (male) are B positive and your fiancee (female) is B negative.

1. According to Rh grouping, a person can have an Rh-positive or Rh-negative group. You both can marry and can produce a normal child. But, you have to take care in your first pregnancy as follows.
2. When pregnant, if the mother is Rh negative and the fetus is Rh positive, then the fetus's RBC can enter into the mother's circulation, and so the mother can develop an antibody against the fetus's Rh-positive cell. It is called sensitization.
3. It will not cause a problem in the first pregnancy, but in the second pregnancy, severe hemolytic disease of the newborn can occur. So, we have to prevent this sensitization when she is pregnant.
4. For that, during the first pregnancy, an intramuscular injection of Rh immunoglobulin should be given at 28 weeks of pregnancy. After delivery, the fetus's blood group was done, and if the fetus was Rh positive, then an extra dose of Rh immunoglobulin was given.

So, just keep this in mind, and in the first pregnancy of your wife (she has a negative group as per history), she should be given Rh(D) immunoglobulin injections in the antenatal period at 28 weeks of gestation.

In addition, before marriage, you both should be investigated for thalassemia minor status.