My M2-PK level is 150. Does it mean that I have cancer?

Q. My M2-PK level is 150. Does it mean that I have cancer?

Answered by
Dr. Sagar Ramesh Makode
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Jul 20, 2018 and last reviewed on: Feb 21, 2023

Hello doctor,

My M2-PK is 150. Does it mean that I have cancer? There was no pain, just a regular checkup. Kindly help.



Welcome to

No, it does not imply cancer alone. Many healthy people, as well as patients with other non-cancerous diseases like rheumatic diseases, diabetic nephropathy, chronic heart diseases, inflammatory bowel disease, pancreatitis, sepsis, may have elevated levels. So there is high false positivity rate as well.

But, since it is elevated and also you being asymptomatic for other diseases I mentioned that it is better to undergo an evaluation to rule out cancer.

Also, the blood test is not a very good test for screening of colorectal cancer (attachment removed to protect patient identity), and it is not recommended due to high false positivity rate, and fecal test M2-PK is a better option.

So, I think you should have a fecal test as well. If positive then we will get a colonoscopy done otherwise you should undergo screening CECT (contrast-enhanced computed tomography) chest and abdomen to look for any cancerous change.

For more information consult an internal medicine physician online -->

Thank you doctor,

What is the difference between M2-PK blood test vs M2-PK stool test? Are they the same? Which one should I be concerned about? As I told you I do not have any symptoms. I am really scared.



Welcome back to

The M2-PK level in blood is not a standardized test, and it can be positive in healthy patients as well also positive in a number of cancerous and noncancerous diseases. So it is a nonspecific test, and positive tests lead to unnecessary evaluation and stress. But since it is positive, we cannot neglect it.

M2-PK positive in the stool is a bit standardized and studied. If it is positive, then it strongly raises the possibility of colorectal cancer, and in that case, one will need a colonoscopy to rule out or rule in cancer. So get a stool test done. And at present do not be scared.

For more information consult an internal medicine physician online -->

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