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Would Zantac make allergy skin test false positive?

Would Zantac make allergy skin test false positive?

The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

iCliniq medical review team

Published At March 7, 2018
Reviewed AtDecember 15, 2023

Patient's Query

Hi doctor,

I have had a history of coughing for a few weeks here and there in spring and fall. It will be fine after about three weeks. Then, my throat will start to itch, and I will begin to have trouble talking. Later, I start coughing explosively. Once I get to the coughing phase, my eyes start watering. It looks like I am crying and I will either cough until I throw up mucus or fluid or vomit if I have just eaten and then I can breathe again. It happens on the bus, at work, and sometimes at night. When I do not have these odd coughing spells, I feel fine. There are no sore throat, vomiting, or GI symptoms. Sometimes I will have the sniffles. I hugged a friend at the dance, and I went from fine to immediate coughing in about 5 to 10 seconds. I will have a few weeks of this, and then it will clear up on its own. Last week, this happened about 10 times, and itchy throat spells where I worked on breathing through it. I am always sucking on throat lozenges during these weeks.

My total IgE level taken during one of these symptoms-filled weeks was 0.0736 mg/dL, where the reference range is less than 0.0416 mg/dL for adults. Medications I was on during testing include Zantac (Ranitidine) just in case it is acid reflux and Ibuprofen for menstrual cramps. They did a skin test this week to try and start figuring things out, and two types of dust mites and something else came back positive. Spirometry is waiting on the results. I have never been able to run a mile outside without stopping to catch my breath a few times. I got bronchitis a lot as a kid. It seemed like if I got a cold, it would inevitably move to my lungs before getting better. My GP was hesitant to order the total IgE level because she said it was often falsely positive. Would Zantac make IgE or allergy skin tests falsely positive? Is this likely to be allergic asthma? How best should I treat it?


Welcome to icliniq.com.

At present, you are suffering from allergic rhinitis converting to allergic asthma.

Get your absolute eosinophilic count done and you need to go for spirometry only at the time of the attack to pinpoint the diagnosis. The differential diagnosis includes allergic bronchiolitis.

I suggest you Fexofenadine 180 mg at night and Pantoprazole 40 mg half an hour before breakfast. If eosinophils are raised, then I suggest you Diethylcarbamazine. Consult your specialist doctor, discuss with him or her, and take treatment.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Atishay Bukharia
Dr. Atishay Bukharia


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