Even after my IgE testing being negative, why do I have diarrhea, nausea and vomiting if I eat anything?

Hello doctor,

I need someone with a lot of experience in allergies. Please tell me what you would do in my situation. Most IgE testing is negative (aside from cow's milk allergy and mold allergy). Yet every single food I have had in the last two years has gone from no reaction (1st day) to a severe reaction entailing diarrhea, nausea, vomiting, throat swelling, and tachycardia over a period of 1 to 2 weeks. I have had two periods of not eating anything but sugar for 1 to 2 months, and after that point, I would regain some tolerance to foods, but it would quickly vanish again. Please help me figure out what to do. Adrenal insufficiency and some nutrient deficiencies are also present, and they are being treated, but other than that, they have no idea what to do.

Hi doctor,

Thank you for the reply.

The more I eat food, the less tolerance I have for it. Do you believe it is because there is a damaged intestinal barrier and too much of the food proteins are leaking into my system, and my body is creating an immune response toward it? These issues with food started about five years ago off and on after a round of antibiotics. I had a UTI. Ever since then, I started having random issues with food that got progressively worse over time. The antibiotics I had were Rocephin, Ciprofloxacin, and Fosfomycin for a pseudomonas UTI I contracted from a cystoscopy. I also lost a lot of weight after that episode, my stool turned gray for a few weeks, and I developed a heart murmur. I cannot really eat small amounts because of hypoglycemia. Potatoes, for example, caused no reaction three weeks ago. Now eating potato chips is making the side of my throat feel like something is growing on it, and I get a bit uncomfortable and short of breath, and if I eat a lot of it, it will make me have a bowel movement with green stool. But none of that happened a few weeks ago. But every single food does this. There is no one food that is permanently safe anymore, it seems. Please help.

I have attached my stool profile. Please give me as much detail as you can in your answer.

Hello doctor,

Thank you for the reply.

Well, what do you think is happening then? With my throat swelling, tachycardia, diarrhea, vomiting, and extreme bloatedness after eating food, I react to it. Also, my throat and mouth get extremely dry rapidly as well. Sometimes there is some mild angioedema in the mouth and lips and redness around the lips.

Please help.