Should I be worried about my stable estradiol levels during the fourth month of pregnancy, as I had recurrent miscarriages in the past?

Hello,

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There has been a rise of 63 percent above in each hCG (human chorionic gonadotrophin) value done after 48 hrs each, which confirms a viable pregnancy and that you are progressing naturally. Estriol levels tend to lower with increasing weeks, and the hCG levels serve as a marker for viability which is fine in your case.

Thank you.

Hello,

Welcome back to icliniq.com.

Estrogen plays a role in initiating an LH (luteinizing hormone) surge before ovulation and also have been known to play a role in better endometrialization and implantation. Still, as the pregnancy grows, the early placenta starts secreting hCG (human chorionic gonadotrophin), which is adequate to maintain the pregnancy, and progesterones secreted by corpus luteum, which, if more than 21 to 40 ng/dl, is considered healthy for developing pregnancy. Although estrogen levels in normal, natural cycles reach 300 to 400 pg/ml before ovulation, a study on donor cycles revealed that the E2 (estradiol) requirement for embryo implantation is low (less than 100 pg/ml). But high peak estriol levels have been associated with lower implantation rates and a higher rate of miscarriages. Hence high estriol levels are not considered good in clinical practice. However, studies are still correlating the rising estradiol levels during pregnancy to viability and healthy progression of pregnancy, but no definite conclusion has been drawn yet.

In clinical practice, HCG support is offered until seven weeks of gestation and followed by progesterone support once the fetal heartbeat arrives to support the pregnancy further.

Hope this helps.

Thank you.