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My serum iron levels are consistently high, but I have symptoms of iron deficiency. Why?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

Dr. Lochana .k

Published At November 3, 2020
Reviewed AtMay 13, 2021

Patient's Query

Hi doctor,

I am consistently doing tests to know my iron levels every month and the results are confusing. I have low ferritin. I am exhibiting classic signs of iron deficiency and even my sclera of eyes have a blue hue on them. But my serum iron levels are consistently high which causes my saturation percentage to remain high. I am not taking any iron supplements. What is the cause of having high serum iron with low ferritin?

Hi,

Welcome to icliniq.com.

You need to consult an endocrinologist for having a high transferrin saturation greater than 50 percent. It creates non-transferrin-bound iron (NTBI) which is toxic and creates damage to certain cells in the body through an oxidation process. When your transferrin saturation is high, you should not take any iron supplements as it is poisonous. You need to do a test for mutations in your HFE (hemochromatosis) genes (C282Y, H63D, and others). Take this seriously as having high transferrin saturation for a longer period can cause irreversible damage to certain tissues like heart and brain.

The Probable causes

You seem to have iron metabolism disorder.

Investigations to be done

You need to do genetic testing for mutations in the HFE (hemochromatosis) gene.

Differential diagnosis

You can have various causes.

Probable diagnosis

You seem to have H63D syndrome. It needs to be tested genetically.

Treatment plan

Stop taking iron supplements.

Regarding follow up

Have a follow-up at any time.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Alexander Davis
Dr. Alexander Davis

General Practitioner

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