Dr. Muhammad Zohaib Siddiq
Cardiology
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Patient's Query
Hi doctor,
I am trying to get answers for my questions for many years. I feel to have heart palpitations and dizzy spells for few days. I got fainted a couple of times without reason. No one has answered my question. I did a 23 and me test. It showed a KCNQ1 mutation and suggest long QT syndrome. Could this cause issues? What to do?
Hi,
Welcome to icliniq.com.
KCNQ1 gene mutation causes long QT Syndrome. It causes delayed repolarization of the heart resulting in delayed relaxation of heart muscles. This is an electrical abnormality of the heart and it can result in palpitations and dizziness or loss of consciousness. In Long QT syndrome, some medicines including antibiotics, antifungals, antidepressants are avoided as these drugs can further prolong QT interval and it can result in torsades de pointes (TdP) which is a life-threatening condition causing fast cardiac rhythm (arrhythmia). A group of drugs called beta-blockers can be used if the QT interval is more than 470 milliseconds, and ICD (implantable cardioverter-defibrillator) is implanted in the heart to prevent sudden cardiac arrest. ECG (electrocardiogram) or holter is used to assess QT interval. Exercise or exertion or contact sports and swimming are prohibited.
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Cardiology
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