Kindly suggest medicines to minimize the muscle and nerve tightening and any new effective medicine for ankylosing spondylitis.

Hello doctor,

• Seven years ago, I was affected by ankylosing spondylitis (HLA-B27 positive) (RF negative).

• And then after a year, I was affected by pulmonary tuberculosis (TB lungs).

• Tuberculosis was controlled within months and I continued taking medication for ankylosing spondylitis.

• And then for a few months I had used homeopathy and ayurvedic medicines. 

• Now I am on SAAZ-DS and NSAIDs.

• Bilateral SI (sacroiliac) joint spaces are reduced and restricted forward movement and other joint movements.

• I am doing light exercise, but in pain. It is a bit difficult.

• Last month, as usual back pain knocked on my right side lower back, but this time muscles got tightened and in the morning when I wake up, pain is so severe.

• Pain is so severe that, even pain killer does not work.

• After few days, the pain disappears and one of the nerve on the same right side back feels like tightened and I feel something like electric shocks.

• Even during sleep, when I wake up there is too much pain.

• I get stuck in one position, but after standing and walking, the pain disappears gradually.

• Again after few days, it reduces gradually but not completely.

• I am now 28 years old and I weigh 66 Kg.

• In the past few months my weight has increased about 6 Kg,

I am requesting you to kindly suggest medicines to minimize the muscle and nerve tightening and any new effective medicine for ankylosing spondylitis.