I am a 48-year-old female with wheatish skin color and melasma. Can I use Glutathione injection for skin whitening?

Q. Do Glutathione injections treat melasma and promote skin whitening?

Answered by
Dr. Sandhya Narayanan Kutty
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Nov 18, 2022 and last reviewed on: Dec 01, 2022

Hello doctor,

I am a 48-year-old female with bright wheatish skin color and melasma, for which I have been using the 5 % Cysteamine cream for the last seven days. But now I would like to take Glutathione injections for skin whitening. Please advise on this.

Thank you.



Welcome to icliniq.com

I read your query and understand your concern.

The Cysteamine cream (Cysteamine Hydrochloride) that you are using currently is a great treatment for reducing the appearance of hyperpigmentation which is caused due to melasma. Tranexamic acid tablets are also used for melasma. However, there are so many other alternative procedures as well as medications that can be used to reduce the chances and the appearance of melasma. Therefore I would like to advise you to try other procedures and treatments which are available as well. Melasma is a skin condition resulting from multiple reasons, including genetic susceptibility, wherein a similar condition runs within the family and may be transmitted genetically. In addition, they may be caused due to hormonal fluctuations and is usually present post-40 years of age due to sudden changes in the hormones, which can happen. Another main reason which leads to melasma is excess sun exposure. Melasma presents as hyperpigmented areas most often formed within the cheeks, sides of the forehead, and nose areas. They are asymptomatic and are usually cosmetically bothersome. They are harmless, but due to being bothered by some, they may be reduced in appearance with multiple procedures and medications. Medications still have limitations due to their penetration being less than that of while undergoing procedures. Therefore, I advise you to undergo procedures coupled with medications.

1. Glutathione treatments are done in multiple forms. It is available as oral medications may be consumed once daily at night after food and may be continued for at least one year for better results. In addition, Glutathione serums may be applied once daily at night and may continue for months or years together. Glutathione creams and face washes are also available, which may be used similarly. However, Glutathione may cause skin photosensitivity, wherein the skin gets sensitized. As a result, it may cause hyperpigmentation, irritation, or skin redness when exposed to the sun for long durations in the morning. Therefore, in case of consuming or applying Glutathione, it is always advised to use an adequate amount of sunscreen on the face and other exposed body parts to prevent sun damage to the skin. Injections available for your condition are any Glutathione treatments in the form of topical or oral medications that may help increase the skin's brightening effect and brighten the skin by a single or two tones rather than causing a whitening effect. It brightens the body as well as facial skin. However, depending upon the skincare routine and maintenance routines, they may last for up to 5 or 6 years if looked after.

2. Apart from the same, there are also other treatments, including platelet-rich plasma (PRP) with micro-needling. It uses one's own blood and extracts the blood growth factors, which are applied to the micropore. Applying platelet-rich plasma helps stimulate the area to reduce the hyperpigmentation intensity. These are usually done in sessions of at least six every four weeks.

3. Glycolic acids with Kojic acid chemical peels are also available, which are solutions supplied onto the face, left for 5 to 10 minutes, and then washed off. This procedure is also done every two weeks for at least six sessions.

4. Laser techniques, including carbon lasers, erbium blazers, and Q switch lasers, are also available in which the laser beams are directed into the melanin under the skin, which destroys the melanin and regularizes their production, thereby reducing the intensity of hyperpigmentation. This is also done every three weeks for at least six sessions.

All these procedures help with reducing the intensity of hyperpigmentation, which is caused due to melanin. These can be used along with the medications and are done at a dermatologist's clinic. Therefore I would like to advise you to consult a dermatologist in person in order to undergo the treatment.

Thank you.

Was this answer helpful?


Same symptoms doesn’t mean you have the same problem. Consult a doctor now!

Related Questions:
Could you suggest some skin-whitening or brightening treatments?

.. writing in, and I understand your concern. I suggest using Ahaglow (Aloe vera Glycolic acid gel) face wash twice a day for atleast two weeks. Skin tone can improve in two to six weeks. Tablet Limcee (Ascorbic acid) 500 mg once a day after breakfast fo   Read full

I have melasma on my face for the last 16 years. Why does not any cream help?

If melasma remains resistant even after taking treatment, then it is good to do chemical peels ...   Read full

Do you prefer Glutathione for skin whitening?

Along with these capsules, you need to drink at least 12 glasses of water per day and also use Dermocalm lotion (Calamine) and sunscreen lotion to aid the effect of these capsules ...   Read full

Also Read Answers From:

ideaComprehensive Medical Second Opinion.Submit your Case

Also Read

PCOS and Liver Problems
The hormonal imbalances in polycystic ovary syndrome could cause liver diseases. Read the article to know the relationship between these medical conditions.  Read more»
Inferior Alveolar Nerve Lateralization Technique
The inferior alveolar nerve lateralization technique is a surgical lateralization technique to reposition the nerve. Read the article to know more about this.  Read more»
COVID-19 and Ebola: Similarities and Differences
This article gives a comparison and broader overview of the outbreak of the two deadliest diseases that showed a greater incidence over the last two decades.  Read more»

Ask your health query to a doctor online?

Ask a Dermatologist Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.