Q. My father is positive for rheumatoid factor and had ankylosing spondylitis. Will I get the same?

Answered by
Dr. Naval Mendiratta
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Dec 08, 2019

Hello doctor,

I have a question relating to my deceased father. I obtained his medical records after his death. While searching through his records to gain a better understanding of what may happen to me, I found he was positive for the rheumatoid factor and had been diagnosed with ankylosing spondylitis. However, the HLA-B27 gene test was negative. I brought this to my rheumatologist and she told me she thought he had something else, but would not elaborate. Does anyone have an idea of what she may thought because she still has not told me? Since then I have switched rheumatologists for that reason. My father passed away from leukemia brought on by myelodysplasia.

I would like to know because doctors still have no idea what may be plaguing me. I have seen multiple doctors for my slightly high CK levels. I have been tested for myelodysplasia, rheumatoid arthritis, multiple muscle diseases, sarcoidosis, and many more. I have not received any answers as of yet.



Welcome to

Well, I do not think you should be worried about anything. Firstly rheumatoid factor is not transmitted genetically unlike HLA- B27 (human leucocyte antigen). Secondly, it can be positive in a lot of people but does not cause any symptoms. Thirdly, you have been tested so far and it has all been negative. Leukemia does carry a family history but you can get your blood checked every six months. One thing you need to understand is, there are no medications as such which can you take which can prevent autoimmune diseases. If it has to happen, it would or else not. But yes, stress would definitely make things worse. So I would suggest just take it easy since you have had negative tests and enjoy your life. Keep a regular health check. Eat healthily and exercise regularly. You have not got any answers since you are healthy.

I hope this helps.

Was this answer helpful?


Same symptoms doesn’t mean you have the same problem. Consult a doctor now!

Related Questions:
Will long time steroid use for RA prevent me from having children?

If I do not take it for a day all my joints start to swell and it is unbearable ... Second is to get an ultrasound of the joints done ... So, that period is tough with a lot of pains and you will have to manage it with safer painkillers like Tylenol ...   Read full

Can I opt biologic Etanercept for ankylosing spondylitis?

.. need to do Mantoux test and interferon gamma level before starting biologics because they can cause reactivation of tuberculosis if there is doubt you should receive the two drug ATT regimen (anti-tubercular treatment) before starting biologics th...   Read full

I have joint pain since delivery, especially in my hands. What could be the reason?

Hello doctor,I am 33 and since having my baby a year ago I am suffering from joint pain, especially in my wrists and fingers ... You have pain in the small joints o...   Read full


Also Read Answers From:

ideaComprehensive Medical Second Opinion.Submit your Case

Also Read

Management of Coronasomnia
Coronasomnia refers to increased sleep problems among people during the COVID-19 pandemic. Read the below article to get...  Read more»
Balantidiasis - Causes, Signs and Symptoms, Diagnosis, Treatment, and Prevention
Balantidiasis is a rare bacterial infection caused by a parasite called Balantidium coli. Read the article below to know...  Read more»
JAK Inhibitors in Treating Rheumatoid Arthritis
Doctors mainly suggest JAK or Janus kinase inhibitors for patients with rheumatoid arthritis to ease their symptoms. Rea...  Read more»

Ask your health query to a doctor online?

Ask a Rheumatologist Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.