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Intestinal Hyperpermeability - Causes and Clinical Correlations

Written by
Dr. Saumya Mittal
and medically reviewed by iCliniq medical review team.

Published on Aug 23, 2014 and last reviewed on Jun 16, 2021   -  3 min read


Increased intestinal permeability results in harmful substances passing through the gastrointestinal tract to the body. Read about the causes and treatment.

Intestinal Hyperpermeability - Causes and Clinical Correlations

Gastrointestinal tract is a continuous tubular structure from the mouth to the anus.

It is lined by epithelial cells.

These epithelia form a protective barrier.

This Barrier Plays an Important Role in:

Intestinal Permeability in Infants:

Conditions and diseases associated with altered intestinal permeability are acute gastroenteritis, alcoholism, ankylosing spondylitis, arthritis, asthma, burn injury, celiac disease, crohn’s disease, cystic fibrosis, eczema, endotoxemia, food allergy, HIV AIDS, use of NSAIDs, pancreatic dysfunction, rheumatoid arthritis, schizophrenia, surgery, trauma, ulcerative colitis, and urticaria.

Causes of Intestinal Hyperpermeability are:

Clinical Correlations of Intestinal Hyperpermeability with other diseases:

Treatment for Intestinal Hyperpermeability:

Consult a medical gastroenterologist online for queries related to intestinal hyperpermeability -->

Frequently Asked Questions


What Is the Treatment for Intestinal Permeability?

Intestinal permeability is managed by lifestyle and dietary modifications, which enhances gut health. For example, probiotic yogurt, and fiber-rich food that includes berries, avocados, whole grains, dry fruits, beans, nuts, potatoes, etc., can help manage leaky gut. In addition, fish oils and foods with glutamine like beef, eggs, white rice, corn, etc., regular exercise, proper sleep, and avoiding stress and smoking can improve it.


What Are the Signs That Indicate Leaking Intestines?

Leaky gut is associated with symptoms like chronic diarrhea and constipation, abdominal bloating, fatigue, confusions, headaches, sugar craving, joint aches, rashes, eczema, reduced attention, and memory loss.


What Foods Increase the Chance of Intestinal Permeability?

Foods that induce intestinal permeability are wheat and wheat products, processed meats like bacon, hot dogs, cold meat, etc., gluten-containing foods including barley, rye, oats, etc., and baked foods like cakes, pizzas, pastries, muffins, cookies, and pies. Also, junk foods, dairy products, artificial sweeteners (saccharin, sucralose), refined oils, sauces, alcohol, carbonated drinks, and sugary drinks should be avoided.


Can Coffee Cause Intestinal Permeability?

Caffeine is a natural stimulant present in coffee that raises the abundance and uniformity of the mucosa-associated gut microbes. As a result, it increases the level of harmless anti-inflammatory bacterias and reduces harmful bacterias in the gut.


What Is the Healing Period of Intestinal Permeability?

The healing period for a leaky gut varies from person to person and usually heals in four to six weeks. However, since the leaky gut is an underlying symptom, the initial step is to treat the underlying cause.


Does a Leaky Gut Treatment Cause Relapse of Autoimmune Disease?

Leaky gut compromises the permeability of the intestinal lining, causing antigens, toxins, and bacteria to enter the blood. As a result, in genetically compromised patients, environmental determinants will enter the body and trigger the autoimmune response, resulting in the relapse of autoimmune diseases.


What Is the Recommended Method to Measure Intestinal Permeability?

Monosaccharide and disaccharide excretion in urine is the suggested method of measurement of intestinal permeability. Lactulose: Mannitol (LM) test is the most common test to assess intestinal permeability.


What Is the Primary Etiology Behind a Leaky Gut?

The primary cause for a leaky gut is a bacterial imbalance in the intestine, stress, inadequate or poor diet, and toxin overload.

Last reviewed at:
16 Jun 2021  -  3 min read




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