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Your wife has been treated for urticaria. I would keep a possibility of idiopathic urticaria/hives.
It presents as sudden skin welts/swellings, which can be distributed all over the body. Itching is usually severe; however it is subjective in individuals.
The causes of urticaria includes various factors such as infections (bacterial, viral or fungal), drugs like painkillers and also certain foods, additives and preservatives.
Physical urticaria can occur due to cold temperature, heat, dermographism, etc., and cholinergic urticaria will occur in response to strong emotions, exercise, spicy food, etc.
Autoimmune urticaria associated usually associated with autoimmune disease such as thyroid, rheumatoid arthritis, systemic lupus erythematosus, etc.
The most common one is idiopathic urticaria, where there will be no underlying identifiable cause.
Regarding treatment, I suggest oral antihistamines like Montelukast and Levocetirizine once daily. Also she can take tablet Allegra 120 mg (Fexofenadine) once daily.
Treatment may sometimes last for months or years. A topical soothing lotion like calamine would help her symptomatically.
Kindly get the food allergy tests and thyroid tests to rule out yeast intolerance.
Revert back with the reports to a dermatologist online --> https://www.icliniq.com/ask-a-doctor-online/dermatologist