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Diagnosis and Management of Gout in Older People

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It is a complicated form of arthritis characterized by frequent big toe pain and sudden episodes of enlargement, reddishness, and discomfort in one or more joints.

Written by

Swetha. R.

Medically reviewed by

Dr. Rajesh Gulati

Published At January 2, 2024
Reviewed AtJanuary 3, 2024

Introduction

Uric acid crystals accumulate in the joints and cause severe pain and inflammation. Gout is a form of inflammatory arthritis that has plagued humanity for centuries, earning it the moniker "the disease of kings" due to its historical association with rich diets and excess. It mainly affects elderly people due to weakness in their health.

What Is the Definition and Types of Gout?

An inflammatory arthritis known as gout (deposition of uric acid crystals) causes extreme discomfort, redness, inflammation, and hardness in the affected joints. Hyperuricemia is a disorder when excessive uric acid in the blood produces it. The main toe is frequently the initially affected joint that gout affects, although it may also impact the ankles, knees, wrists, and fingers.

Types of Gout:

1. Acute Gout: Acute gout is the most common type and suddenly occurs. It attacks joints and produces pain, inflammation, and redness. These attacks often occur at night and can last a few days to a few weeks. Factors like dietary purine intake, alcohol consumption, dehydration, or certain medications typically trigger acute gout.

2. Chronic Gout: Chronic gout develops when left untreated or inadequately managed over time. It involves repeated gout attacks and urate crystal buildup in the tissues and joints. Tophi, lumps or nodules of uric acid crystals under the skin or within the joints, can develop due to chronic gout. Deformations and joint injury are possible with these tophi.

3. Pseudogout: The disorder known as pseudogout (calcium pyrophosphate deposition disease) is similar to gout but is brought on by the buildup of calcium pyrophosphate crystals in the joints. The pseudogout symptoms can mimic gout, including joint pain and inflammation. It is a separate condition with different underlying causes and treatments.

4. Asymptomatic Hyperuricemia: Some individuals may have elevated uric acid levels in their blood (hyperuricemia) without experiencing gout attacks or symptoms. This is known as asymptomatic hyperuricemia. While not all individuals with hyperuricemia will develop gout, it is a risk factor.

5. Tophaceous Gout: Tophaceous gout refers to advanced chronic gout where tophi (collections of urate crystals) have formed in and around the joints and soft tissues. These tophi can cause joint damage, deformities, and skin ulcerations.

What Are the Causes of Gout?

Gout is largely caused by nutrition, and older people are frequently more susceptible as a result of their consuming food choices. Gout is more likely to occur in individuals who consume a diet high in purines. Purines (natural substances) are metabolized into uric acid in the body. Foods rich in purines include red meat, organ meats (like liver and kidneys), seafood (particularly shellfish), and high-fructose corn syrup-sweetened beverages. Older people who have a diet rich in these foods may have an increased risk of gout. Gout becomes more prevalent with age.

Kidneys may not function as efficiently as they did in their youth. Filtering and removing uric acid from the body is the kidneys' essential function. Higher blood uric acid levels brought on by impaired renal function can raise the risk of gout. Gout is more likely to occur in persons who are considered obese, and this risk increases with age. Increased body weight leads to raised uric acid (in the blood) and increased pressure on joints, which may trigger gout attacks. Gout is more common in men than in women, but as individuals age, the gender gap narrows, and postmenopausal women become more susceptible to gout due to hormonal changes.

Excessive alcohol intake, particularly beer and hard liquor, causes gout. Older individuals who continue to consume alcohol excessively may be at a higher risk. Dehydration can lead to higher uric acid concentrations in the blood. Older individuals may be more susceptible to dehydration due to various factors, including decreased thirst perception and reduced kidney function.

How to Diagnose Gout in Older People?

Medical history is important for the treatment of gout. This includes asking about the patient's symptoms, the timing and frequency of gout attacks, any known risk factors, and any family history of gout or other joint conditions. The medical professional will search for inflammation-related symptoms like irritation, temperature, swells, and fatigue. They may also examine other joints for any involvement. Gout symptoms can overlap with other joint conditions, such as osteoarthritis, rheumatoid arthritis, and infectious arthritis.

Blood tests can help support a gout diagnosis by finding the level of uric acid in the blood. While elevated uric acid levels can be indicative of gout, it is important to note that not all individuals with gout have high uric acid levels during an acute attack. Additionally, some people may have elevated uric acid levels without experiencing gout symptoms. To definitively diagnose gout, a procedure called joint fluid analysis or synovial fluid aspiration is often performed. A needle is used to withdraw fluid from the affected joint.

The fluid is then examined under a microscope for uric acid crystals. X-rays, ultrasound, or other imaging studies may be used to assess the joint damage caused by chronic gout. These studies can help determine the extent of joint involvement and any structural changes. Healthcare providers may also refer to established clinical criteria for diagnosing gout, such as the American College of Rheumatology criteria. These criteria consider various clinical and laboratory factors to make a diagnosis.

How to Manage Gout in Older People?

Encourage elderly patients to make dietary modifications to reduce purine intake. This includes limiting high-purine foods like red meat, organ meats, shellfish, and sugary beverages. Adequate hydration is also important to help flush excess uric acid from the body. Weight Management during obesity is a risk factor for gout. Older individuals with gout should strive to maintain a healthy body weight. Reducing alcohol consumption, especially beer and hard liquor, reduces the cause of gout.

Staying well-hydrated can help prevent the buildup of uric acid in the body. Encourage older individuals to drink plenty of water throughout the day. Gentle exercises and physical therapy can help maintain joint function and mobility. However, choosing exercises appropriate for the individual's age and physical condition is essential. During a gout attack, resting the affected joint is crucial to reduce pain and inflammation. Using a splint or brace may help immobilize the joint and provide relief. Older individuals with gout should receive regular follow-up care with their healthcare provider. This includes monitoring uric acid levels, assessing medication efficacy, and adjusting the treatment plan.

It is essential to educate elderly patients about their condition, triggers for gout attacks, and the importance of adhering to treatment and lifestyle recommendations. Gout can affect joint function and mobility; elderly individuals with gout should take precautions to prevent falls and fractures, including using assistive devices if needed.

Conclusion:

Gout is a painful condition that predominantly affects older individuals. Its diagnosis and management require a multifaceted approach, considering both acute symptom relief and long-term prevention. Older patients should work closely with medical professionals to create a specific treatment program that considers their particular needs and way of life. With proper care and management, the burden of gout can be significantly reduced, enhancing the quality of life for older individuals living with this condition.

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Swetha. R.
Swetha. R.

Pharmacology

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