What Is Aquagenic Urticaria?
Urticaria is a common ailment characterized by the appearance of a red, raised, and itchy rash. It is famously called hives. One type of hive, called aquagenic urticaria, is a sporadic condition.
Water is integral to daily life and generally harmless for most people. However, it can be a source of discomfort and irritation for some individuals. As evident by the name of this condition, aquagenic urticaria causes rashes to appear after one comes in contact with water. It is a type of physical hive, and those affected with this condition often develop red skin that itches and burns when they touch the water.
Urticaria, or hives, usually range from a few millimeters (mm) to several centimeters (cm) in size and may occur anywhere on the body. However, in aquagenic urticaria, the size of the hives is usually only one to three millimeters. Hives being itchy may often cause a lot of discomforts.
The condition has predominance in females, with most cases being sporadic.
Aquagenic urticaria is a rare condition, but sometimes it is possible to mistake it for some other more common types of urticaria. These types include cold urticaria and cholinergic urticaria, also known as heat hives.
Aquagenic urticaria can also be triggered from many water sources, including:
-
Rain.
-
Snow.
-
Sweat.
-
Tears.
What Are the Symptoms of Aquagenic Urticaria?
The rash that develops in aquagenic urticaria is made of small, raised bumps surrounded by larger, reddened areas. The bumps may be itchy and painful and most commonly appear on the neck, the upper arms, and the chest. But these can appear anywhere on the body.
Sometimes the person develops other symptoms, including headache, shortness of breath, wheezing, dizziness, and fainting.
Immediately after being exposed to water within a few minutes (up to 30 minutes), the symptoms that show up include:
-
Erythema (reddening) of the skin.
-
Burning sensation.
-
Lesions on the skin.
-
Welts (raised red bumps).
Some rare symptoms that can be experienced include dyspnea (shortness of breath) and wheezing (whistling sound during breathing). These symptoms generally subside when the person is no longer in contact with water and takes approximately 30 to 60 minutes to subside.
What Causes Aquagenic Urticaria?
Doctors often treat hives without knowing the cause of the rash. In the case of chronic hives (long-standing cases), they are able to identify only about 10 to 20 percent of the causes. However, when the cause is evident, they may not understand the mechanism that triggers the formation of a rash. Doctors and scientists are similarly puzzled about aquagenic urticaria.
The exact causes that lead to aquagenic urticaria are still unknown. Scientists are still working on it. They have proposed several theories or mechanisms that may be causing this water allergy, which includes the following:
-
Some speculate the substances dissolved in water, the chemical additives such as chlorine, cause a reaction and the formation of rash, rather than contact with water itself. But they are unable to find a definitive explanation.
-
Another proposed mechanism is that water, after coming in contact with the skin, may interact with sebum (skin oils), triggering allergy cells to release specific proteins called histamines. Histamines are released in response to an allergic reaction to fight off the harmful foreign substance. The allergy-like symptoms experienced in aquagenic urticaria may be due to the release of histamines.
It is important to note that the causes of aquagenic urticaria have not been widely studied, and further research is necessary to understand the condition better.
Also, no known risk factors have been identified for aquagenic urticaria. More than one case can be seen in a family, but most cases are not present in family groups. A few people having aquagenic urticaria have had other hereditary conditions. But the number of cases is not enough to determine whether it might be an inheritable condition or it might be part of a larger syndrome.
How Is Aquagenic Urticaria Diagnosed?
The healthcare provider may conduct a physical examination to initially observe the symptoms and take a review of the medical history to diagnose aquagenic urticaria.
Water Challenge Test
-
To effectively diagnose a water allergy, they may also perform a water challenge test.
-
This test is performed by placing a warm damp cloth (approximately 95 degrees Fahrenheit), which acts as a water compress, on the upper body for almost 20 minutes. This process is done to trigger an allergic reaction. The appearance of symptoms indicates water allergy.
-
This water challenge test also helps to compare and differentiate aquagenic urticaria from the other forms of urticaria as well as to symptoms of aquagenic pruritus. Aquagenic pruritus involves itching and irritation but does not cause hives or redness.
-
It is important to note that the patient must not consume any antihistamine medication before the test.
What Is the Treatment of Aquagenic Urticaria?
There is no cure currently for aquagenic urticaria, but there are several treatment options available that can help alleviate the symptoms. However, it is important to note that because of the rarity of this condition, its treatment has not been widely studied by scientists.
The common treatment options for managing the symptoms may include:
-
Antihistamines: Several symptoms of aquagenic urticaria are supposed to be caused due to the release of histamines. Therefore, oral prescription antihistamines may be considered the first line of treatment.
-
Topical Therapies: Topical application of oil-based emulsions and petroleum-containing creams may act as a barrier between the skin and water and thereby help to treat symptoms of water allergy in some people.
-
Phototherapy: A healthcare provider may recommend phototherapy if oral and topical treatments are unable to give the desired results. Phototherapy involves ultraviolet radiation, and it acts by making the skin tough and thus less sensitive to water, like the palms of the hands and soles of the feet.
-
Other Medications: Anabolic steroids (Stanozolol), selective serotonin reuptake inhibitors (SSRIs), and asthma medication (Omalizumab) may help to treat aquagenic urticaria.
In case of severe aquagenic urticaria that results in breathing problems, an EpiPen may be needed. EpiPens contain epinephrine, another name for adrenaline. They are only used for severe allergic reactions as an emergency alternative. EpiPens also work by increasing blood pressure for the reduction of swelling and hives.
Conclusion:
Aquagenic urticaria or water allergy is a type of urticaria that occurs when skin contacts water. This causes the development of hives at the site of contact. One must always consult a doctor if one suspects having an allergy. The symptoms of water allergy may overlap with the symptoms of other common types of hives, such as cold urticaria (cold-induced) and cholinergic urticaria (heat-induced). Therefore, a proper diagnosis is required for the appropriate treatment.