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Aquagenic Urticaria - Diagnosis and Ways to Treat

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Aquagenic urticaria, also known as water allergy, is a rare condition in which a rash occurs when skin is exposed to water. Let us learn about it in detail.

Medically reviewed by

Dr. Dhepe Snehal Madhav

Published At January 6, 2023
Reviewed AtFebruary 23, 2023

What Is Aquagenic Urticaria?

Urticaria is a common ailment characterized by the appearance of a red, raised, and itchy rash. It is famously called hives. One type of hive, called aquagenic urticaria, is a sporadic condition.

Water is integral to daily life and generally harmless for most people. However, it can be a source of discomfort and irritation for some individuals. As evident by the name of this condition, aquagenic urticaria causes rashes to appear after one comes in contact with water. It is a type of physical hive, and those affected with this condition often develop red skin that itches and burns when they touch the water.

Urticaria, or hives, usually range from a few millimeters (mm) to several centimeters (cm) in size and may occur anywhere on the body. However, in aquagenic urticaria, the size of the hives is usually only one to three millimeters. Hives being itchy may often cause a lot of discomforts.

The condition has predominance in females, with most cases being sporadic.

Aquagenic urticaria is a rare condition, but sometimes it is possible to mistake it for some other more common types of urticaria. These types include cold urticaria and cholinergic urticaria, also known as heat hives.

Aquagenic urticaria can also be triggered from many water sources, including:

  • Rain.

  • Snow.

  • Sweat.

  • Tears.

What Are the Symptoms of Aquagenic Urticaria?

The rash that develops in aquagenic urticaria is made of small, raised bumps surrounded by larger, reddened areas. The bumps may be itchy and painful and most commonly appear on the neck, the upper arms, and the chest. But these can appear anywhere on the body.

Sometimes the person develops other symptoms, including headache, shortness of breath, wheezing, dizziness, and fainting.

Immediately after being exposed to water within a few minutes (up to 30 minutes), the symptoms that show up include:

  • Erythema (reddening) of the skin.

  • Burning sensation.

  • Lesions on the skin.

  • Welts (raised red bumps).

  • Itching.

Some rare symptoms that can be experienced include dyspnea (shortness of breath) and wheezing (whistling sound during breathing). These symptoms generally subside when the person is no longer in contact with water and takes approximately 30 to 60 minutes to subside.

What Causes Aquagenic Urticaria?

Doctors often treat hives without knowing the cause of the rash. In the case of chronic hives (long-standing cases), they are able to identify only about 10 to 20 percent of the causes. However, when the cause is evident, they may not understand the mechanism that triggers the formation of a rash. Doctors and scientists are similarly puzzled about aquagenic urticaria.

The exact causes that lead to aquagenic urticaria are still unknown. Scientists are still working on it. They have proposed several theories or mechanisms that may be causing this water allergy, which includes the following:

  • Some speculate the substances dissolved in water, the chemical additives such as chlorine, cause a reaction and the formation of rash, rather than contact with water itself. But they are unable to find a definitive explanation.

  • Another proposed mechanism is that water, after coming in contact with the skin, may interact with sebum (skin oils), triggering allergy cells to release specific proteins called histamines. Histamines are released in response to an allergic reaction to fight off the harmful foreign substance. The allergy-like symptoms experienced in aquagenic urticaria may be due to the release of histamines.

It is important to note that the causes of aquagenic urticaria have not been widely studied, and further research is necessary to understand the condition better.

Also, no known risk factors have been identified for aquagenic urticaria. More than one case can be seen in a family, but most cases are not present in family groups. A few people having aquagenic urticaria have had other hereditary conditions. But the number of cases is not enough to determine whether it might be an inheritable condition or it might be part of a larger syndrome.

How Is Aquagenic Urticaria Diagnosed?

The healthcare provider may conduct a physical examination to initially observe the symptoms and take a review of the medical history to diagnose aquagenic urticaria.

Water Challenge Test

  • To effectively diagnose a water allergy, they may also perform a water challenge test.

  • This test is performed by placing a warm damp cloth (approximately 95 degrees Fahrenheit), which acts as a water compress, on the upper body for almost 20 minutes. This process is done to trigger an allergic reaction. The appearance of symptoms indicates water allergy.

  • This water challenge test also helps to compare and differentiate aquagenic urticaria from the other forms of urticaria as well as to symptoms of aquagenic pruritus. Aquagenic pruritus involves itching and irritation but does not cause hives or redness.

  • It is important to note that the patient must not consume any antihistamine medication before the test.

What Is the Treatment of Aquagenic Urticaria?

There is no cure currently for aquagenic urticaria, but there are several treatment options available that can help alleviate the symptoms. However, it is important to note that because of the rarity of this condition, its treatment has not been widely studied by scientists.

The common treatment options for managing the symptoms may include:

  • Antihistamines: Several symptoms of aquagenic urticaria are supposed to be caused due to the release of histamines. Therefore, oral prescription antihistamines may be considered the first line of treatment.

  • Topical Therapies: Topical application of oil-based emulsions and petroleum-containing creams may act as a barrier between the skin and water and thereby help to treat symptoms of water allergy in some people.

  • Phototherapy: A healthcare provider may recommend phototherapy if oral and topical treatments are unable to give the desired results. Phototherapy involves ultraviolet radiation, and it acts by making the skin tough and thus less sensitive to water, like the palms of the hands and soles of the feet.

  • Other Medications: Anabolic steroids (Stanozolol), selective serotonin reuptake inhibitors (SSRIs), and asthma medication (Omalizumab) may help to treat aquagenic urticaria.

In case of severe aquagenic urticaria that results in breathing problems, an EpiPen may be needed. EpiPens contain epinephrine, another name for adrenaline. They are only used for severe allergic reactions as an emergency alternative. EpiPens also work by increasing blood pressure for the reduction of swelling and hives.

Conclusion:

Aquagenic urticaria or water allergy is a type of urticaria that occurs when skin contacts water. This causes the development of hives at the site of contact. One must always consult a doctor if one suspects having an allergy. The symptoms of water allergy may overlap with the symptoms of other common types of hives, such as cold urticaria (cold-induced) and cholinergic urticaria (heat-induced). Therefore, a proper diagnosis is required for the appropriate treatment.

Frequently Asked Questions

1.

How Can Aquagenic Urticaria Be Treated?

Getting rid of aquagenic urticaria can be challenging because it is a rare condition characterized by hives or skin welts that develop in response to water exposure. Management typically involves avoiding triggers like hot or cold water and using antihistamines to alleviate symptoms. In cases where antihistamines prove ineffective, a physician may consider adding Omalizumab to the treatment plan to help prevent flare-ups. Some individuals may find relief through desensitization therapy, but complete eradication of aquagenic urticaria can be difficult.

2.

What Causes Aquagenic Urticaria in People?

The precise origins of water allergy remain uncertain. Scientists have put forth several potential mechanisms that could contribute to developing a water allergy. Limited evidence indicates that water might dissolve allergenic substances on the skin's surface. This dissolution could trigger allergy cells, known as mast cells, either on the skin's surface or deeper beneath the top layer of the skin. Another proposed mechanism suggests that water could interact with the skin's natural oils, or sebum, produced by oil glands, directly irritating allergy cells and prompting the release of histamines, proteins associated with allergic reactions.

3.

Is It Safe for Individuals With Aquagenic Urticaria to Consume Water?

Individuals with aquagenic urticaria can drink water without causing hives or allergic reactions internally. This condition primarily affects the skin upon contact with water; internal water consumption is generally safe. While some individuals with aquagenic urticaria can consume water if they prevent it from coming into contact with their skin, it is important to be aware that a more severe allergic reaction can arise unpredictably. This heightened sensitivity can result in swollen lips and irritation within the mouth and throat. In the most severe cases, the act of drinking water can even lead to anaphylaxis, a potentially life-threatening response.

4.

Will Aquagenic Urticaria Cause Discomfort or Pain?

Aquagenic urticaria can indeed be painful. Patients may also encounter related symptoms such as itching, burning, and a bothersome tingling sensation. Urticarial rashes typically disappear within 30 to 60 minutes after water contact with the skin stops. These rashes most frequently manifest on the trunk and upper arms, usually avoiding the palms and soles. The areas affected tend to remain unresponsive to repeated stimuli for several hours. In rare instances, patients may develop systemic symptoms like wheezing or breathlessness.

5.

Is There a Cure for Aquagenic Urticaria?

There is currently no known cure for aquagenic hives, but treatment options are available to alleviate the associated symptoms. To address the itching, swelling, and irritation on a short-term basis, it is typically recommended to use an antihistamine. Antihistamines are medications commonly used to treat allergy-like symptoms. Ideally, the preferred choice would be a second-generation antihistamine with fewer sedative effects, such as Cetirizine or Loratadine. These can be taken before anticipated water exposure to help prevent the onset of hives.

6.

What Natural Remedies Can Be Used to Minimize Aquagenic Urticaria Symptoms?

To alleviate symptoms of aquagenic urticaria naturally, one can consider using cold compresses, taking soothing oatmeal baths, applying aloe vera gel to affected areas, and minimizing water exposure by using lukewarm water and hypoallergenic soaps during showers. Staying hydrated with water intake through a straw, incorporating potential natural antihistamine foods like ginger and garlic into the diet, practicing stress-reduction techniques such as meditation or yoga, and making dietary adjustments to avoid trigger foods can also be helpful.

7.

What Is the Usual Duration for Aquagenic Urticaria Symptoms to Disappear?

Usually, urticarial rashes tend to clear up within 30 to 60 minutes once water contact with the skin stops. In some cases, urticaria may resolve within hours; in others, it can last for days or weeks. The speed at which it goes away depends on factors like the trigger and individual sensitivity.

8.

Is It Possible to Manage and Live With Aquagenic Urticaria?

Individuals can live with aquagenic urticaria, but they must be cautious and avoid water exposure, especially hot or cold water. Individuals can lead relatively normal lives with proper management and avoidance of triggers. As water contact is unavoidable, patients anticipate the development of wheals, leading to increased anxiety, depression, and elevated stress levels. Eating and drinking can also become sources of stress, as any contact with water or the induction of sweat by spicy foods can prompt allergic reactions.

9.

How Serious Is Aquagenic Urticaria as a Health Issue?

Aquagenic urticaria is a serious condition as it can cause significant discomfort and affect a person's quality of life. While it is not life-threatening, the pain and inconvenience associated with frequent episodes of hives can be distressing. A highly uncommon condition called aquagenic urticaria (AU) results in itchy, red hives or swelling upon skin contact with water. In severe instances, it may even lead to symptoms such as wheezing or breathlessness.

10.

Can Urticaria Extend to Different Areas of the Body?

Urticaria, including aquagenic urticaria, typically does not spread from person to person. It is a skin condition triggered by specific stimuli, such as water or allergens, and is not contagious. Aquagenic urticaria, a rare condition, typically does not spread like traditional hives. Instead, it occurs upon contact with water and manifests as localized reactions, such as itchy, red hives, or swelling, mainly in areas exposed to water. These reactions tend to be limited to the areas of skin that come into contact with water and do not typically spread to other body parts.

11.

Is Aquagenic Urticaria Genetically Inherited?

Aquagenic urticaria is not typically considered a genetic disorder like other medical conditions inherited through specific genetic mutations. Instead, it is often classified as an acquired or idiopathic condition, meaning it develops without a clear genetic cause in most cases. However, there have been rare instances where aquagenic urticaria appears to run in families, suggesting a potential genetic component in some cases. Still, the exact genetic mechanisms need to be better understood.

12.

How Common Is Aquagenic Urticaria Worldwide?

Aquagenic urticaria is an extremely rare condition, and the exact prevalence in the global population is not well-documented. It is estimated to affect only a very small number of individuals, making it an exceptionally uncommon disorder. Precise statistics regarding the percentage of the world's population with aquagenic urticaria are not readily available due to its rarity.

13.

Can Aquagenic Urticaria Be Classified as a Disabling Condition?

Whether aquagenic urticaria qualifies as a disability depends on its impact on an individual's daily life and ability to perform essential tasks. While it is a rare and challenging condition, not all cases would necessarily be classified as a disability. In some instances, aquagenic urticaria can severely impair a person's ability to engage in routine activities, work, or maintain their overall well-being.

14.

Are There Any Adverse Outcomes or Risks Linked to Aquagenic Urticaria?

Complications of aquagenic urticaria can include skin discomfort with symptoms like itching and burning upon water contact, psychological distress such as anxiety and depression, disruptions in daily life due to the need to avoid water exposure, potential social isolation, severe systemic reactions like anaphylaxis in severe cases, and the risk of secondary infections from scratching itchy hives. Effective management and professional guidance are crucial to address these challenges and minimize complications.

15.

Can Warm Water Help Alleviate Water Allergy?

Warm water may relieve the symptoms of water allergies like aquagenic urticaria, as it may be less likely to trigger a reaction than cold water. Some individuals find that using lukewarm water during showers or baths is more tolerable. However, it is important to note that warm water may not eliminate the risk of symptoms, and the effectiveness can vary from person to person.

Dr. Dhepe Snehal Madhav
Dr. Dhepe Snehal Madhav

Venereology

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