Q. Can Seroquel cause abdominal rigidity and pain?

Answered by
Dr. Aida Abaz Quka
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Mar 01, 2022 and last reviewed on: Feb 24, 2023

Hello doctor,

My husband has had muscle rigidity in his abdominal muscles for days. I feel it is a side effect of tablet Seroquel. He is weaning off of tablet Seroquel in hopes that it will help. So far, it just continues to get worse. What can he do to manage the symptom? It is miserable for him and painful. He does have chronic pancreatitis from addiction, but he has been sober for three years. And this symptom is outside of the pancreatitis symptoms. He does not get that as often. He does not think anyone will believe or help him, and I hate seeing him miserable. What can he do to alleviate this symptom? He tried some old tablet Cyclobenzaprine that I had, but it did nothing. So I am not sure what to do. This has been going on for months and continues to get worse. I do not feel he ever had this before taking tablet Seroquel. Please advise.



Welcome to

I understand your concern and would like to know if he has abdominal pain or constipation. Before concluding that it is just muscle spasm, I suggest performing an abdominal ultrasound, a cervicothoracic X-ray study, and some laboratory blood tests (liver and kidney function tests, amylase and lipase, vitamin D, plasma levels, blood electrolytes, and blood pressure). I suggest you discuss with his doctor the above tests. In the meantime, I would suggest tablet Spasmex 20 mg/500 mg (Dicyclomine 20 mg and Paracetamol 500 mg) or tablet Buscopan 10 mg (Hyoscine butylbromide). Warm compressions can also help.

Thank you.

Thank you doctor,

I am confident this is not constipation or issues with his stomach. You can see it clearly when he lifts his shirt. He is flexing for a photo to show off his abs. Only he does not want to flex his abs. He has been feeling them, and I do, and they are hard as a rock. He has talked to his doctor, but he gets pushed to the side because of his past. I try to get him checked out, and he says no one will do anything to help him anyway. And I have seen it too. They do tend to push him aside. And tell him to try heat, much like you said. He does heat regularly. He got in the hot tub he bought me for my neck injury, which led to a pinched nerve. And oddly, the muscle-flexing got worse. Are there any over-the-counter muscle relaxant-type products he could use that will help? Could this be from tablet Seroquel's extrapyramidal side effects? If so, how long after wearing off will it go away? And why does it seem to be worse during weaning off? We only have one available neurologist in my town, and he is who I see, but he was severely injured from a fall a few months back and has not been able to come back to the office yet. And he is hard to get into. But I mentioned it to him. He said the medication side effects as a possibility, among several others. That one seemed to make the most sense. He will push on his stomach, stretch, do deep tissue massage, electrical stimulation, etc., and nothing works. We have tried everything. I had him take tablet Benadryl, an anticholinergic tablet Flexeril, though it was two years old, heat, ice, massage, e-stem, stretching, deep tissue, trigger point release, etc., nothing is working. He remains miserable, and the rigidity then, of course, becomes painful like any spasms lasting a long time. He has been struggling with this for at least a year, and it only seems to be getting worse. Can it get worse when wearing off? The only explanation is the tablet Seroquel or something else neurological possibly mixed with psychological but not purely psychological. He does have severe anxiety, and this issue ramps up his anxiety, but he is not anxious when it initially starts. But his misery is leading to my misery because he is then very unpleasant to be around. We are divorced and were reconciling due to his prolonged sobriety. But with his mood continuously changing, he gets very on edge, and there is no calming him. He wants it to stop. There is a distinct difference when he has a flare-up of pancreatitis. It is very different. And his stomach, as far as digestion, will be just fine when the abdominal muscle rigidity hits. I wish I knew how to help him. Please help.



Welcome back to

I do not think that this is an adverse effect of the tablet as it would get better with the reduction in the dose of the drug. It could be psychological or vitamin deficiency (a metabolic disorder). I suggest Magnesium supplements 300 to 400 mg daily. Unfortunately, there is no other over-the-counter drug besides oral Flexeril (Cyclobenzaprine). Coming to this point, I would suggest taking tablet Clonazepam orally, which can help against muscle spasms and calm anxiety. This is not an over-the-counter medication, and you should discuss this possible treatment option with his doctor. I would also suggest checking for possible deficiency in vitamin D, B1, and vitamin B12 plasma levels. I hope this helps.

Thank you.

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