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HomeAnswersRheumatologyankylosing spondylitisHow do I overcome muscle and nerve tightening? Please help.

Kindly suggest medicines to minimize the muscle and nerve tightening and any new effective medicine for ankylosing spondylitis.

The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

iCliniq medical review team

Published At February 17, 2015
Reviewed AtFebruary 6, 2024

Patient's Query

Hello doctor,

  • Seven years ago, I was affected by ankylosing spondylitis (HLA-B27 positive) (RF negative).
  • And then after a year, I was affected by pulmonary tuberculosis (TB lungs).
  • Tuberculosis was controlled within months and I continued taking medication for ankylosing spondylitis.
  • And then for a few months I had used homeopathy and ayurvedic medicines. 
  • Now I am on SAAZ-DS and NSAIDs.
  • Bilateral SI (sacroiliac) joint spaces are reduced and restricted forward movement and other joint movements.
  • I am doing light exercise, but in pain. It is a bit difficult.
  • Last month, as usual back pain knocked on my right side lower back, but this time muscles got tightened and in the morning when I wake up, pain is so severe.
  • Pain is so severe that, even pain killer does not work.
  • After few days, the pain disappears and one of the nerve on the same right side back feels like tightened and I feel something like electric shocks.
  • Even during sleep, when I wake up there is too much pain.
  • I get stuck in one position, but after standing and walking, the pain disappears gradually.
  • Again after few days, it reduces gradually but not completely.
  • I am now 28 years old and I weigh 66 Kg.
  • In the past few months my weight has increased about 6 Kg,

I am requesting you to kindly suggest medicines to minimize the muscle and nerve tightening and any new effective medicine for ankylosing spondylitis.


Welcome to icliniq.com.

Following are the answers for your queries:

  • Get an  MRI LS spine done, to see for any disc prolapse as the pain you are describing along with tingling sensation is seen in disc prolapse only.
  • A combination of Pregabalin and Methylcobalamine will help you in neuropathy pain.
  • For ankylosing spondylitis, you can go for biological therapy drug like Rituximab.
  • Effective NSAID would be Etoricoxib. For severe pain you may take Tramadol.

Stay healthy.

Revert back with the reports to a rheumatologist online --> https://www.icliniq.com/ask-a-doctor-online/rheumatologist

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Anshul Varshney
Dr. Anshul Varshney

Internal Medicine

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