How can polydipsia and TD be cured in a manic-depressive patient?

Q. How can polydipsia and TD be cured in a manic-depressive patient?

Answered by
Dr. Nidhi Jain
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Mar 19, 2018 and last reviewed on: Jun 22, 2023

Hello doctor,

I was diagnosed as manic-depressive (now bipolar 1) 43 years back. For many years I was on Lithium and then subsequently on Haloperidol. Then, I switched over to Valproate 18 years back. The results of the Lithium and Haloperidol were polydipsia and TD. TD was treated with Quetiapine, and over many years it almost got eliminated. Polydipsia was treated with Amiloride HCTZ and Telmisartan. So, now it is reduced to three liters daily. Now, I am on Lamotrigine and Oxcarbazepine. There are no side-effects. For sleep, I use Melatonin and Asenapine 2.5 mg. Can you recommend a better treatment protocol which I can try out for all the four problems? Thank you.



Welcome to

How many episodes you had in the past? Why are you taking medication for the last 43 years? Kindly, revert back. Thank you and take care. Regards.

Thank you doctor,

I had four episodes. Since then only brief hypomania was there that lasted for one week but got treated. Thank you.



Welcome back to

If you had four manic/depressive episodes with few hypomanic episodes in the past, then you need to continue medicines. For bipolar illness, only four mood stabilizers are available (Lithium, Sodium valproate, Carbamazepine or Oxcarbazepine and Lamotrigine). And you tried all in the past. Sodium valproate or Divalproex sodium is a good choice for patients with a history of multiple episodes. For antipsychotic medication, you are having a number of options like Olanzapine, Risperidone, etc. So, if you are maintaining well on your treatment, then do not think to change it now. Continue the same (Lamotrigine and Oxcarbazepine). Later on, if you get any problem, then we can think to change. Thank you and take care. Regards.

Hello doctor,

What about psychogenic polydipsia and Lithium-induced nephrogenic polydipsia? What about TD? What are the options? Thank you.



Welcome back to

Psychogenic polydipsia is found in mental illnesses like schizophrenia, etc. For that, psychiatric illness should be treated. Lithium also can induce polydipsia after long-term intake. For that, it is better to switch on to another mood stabilizer or can start diuretics. TD (tardive dyskinesia) is the side effect of long-term antipsychotic intake. It is mainly by first-generation antipsychotic like Haloperidol, etc. So, it is better to give second generation antipsychotic in bipolar illness. Other options for TD, I suggest Clozapine, multivitamin, Ginkgo biloba (Flavonol, Flavone, Ginkgolides), etc. Thank you. Regards.

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