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Is PEP effective even after a risk exposure to HIV?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hi doctor,

Is PEP (Post-exposure prophylaxis) effective after a risk exposure?

Kindly guide.

Answered by Dr. Kakkar

Hi,

Welcome to icliniq.com.

It is not 100 percent protective against HIV (human immunodeficiency virus). However, it significantly reduces the chances by over 80%. Please mention the mode of exposure.

I hope this helps.

Please follow up if you have any further concerns.

Thank you.

Patient's Query

Thank you doctor,

I did insertive anal sex.

Answered by Dr. Kakkar

Hi,

Welcome back to icliniq.com.

Insertive anal sex carries a risk of transmission of HIV varying from 0.11 % to 0.62 %. Please say whether you are circumcised. Please explain the protection used.

Thank you.

Patient's Query

Thank you doctor,

I am circumcised, and I have not used protection. Can I take PEP medications now?

Answered by Dr. Kakkar

Hi,

Welcome back to icliniq.com.

Yes, PEP is recommended as it was a high-risk unprotected sex. It is better to start early to reduce the chance of getting HIV.

I hope this helps.

Thank you.

Answered byDr. Kakkar

Medically reviewed byiCliniq medical review team

Published At March 19, 2018
Reviewed AtDecember 24, 2025

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Dr. Kakkar

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