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Can varicoceles cause male infertility?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Answered by

Dr. Sameer Kumar

Medically reviewed by

iCliniq medical review team

Published At June 19, 2023
Reviewed AtJune 19, 2023

Patient's Query

Hello doctor,

I had a scrotum ultrasound done. I am attaching my reports. I want to understand the result. Some doctors said it is grade 1 varicocele on the right side. Will the varicocele impact my fertility?

Please help.

Answered by Dr. Sameer Kumar

Hello,

Welcome to icliniq.com.

I went through your query and understood your concern.

I went through your reports (the attachments removed to protect the patient's identity). Varicoceles are classified as grade 0 (2 to 2.5 millimeters), grade 1 (2.5 to 3 millimeters), grade 2 (3 to 3.5 millimeters), or grade 3 (more than 3.5 millimeters). There are various other gradings, but the Valsalva maneuver is performed to increase blood flow and check for flow reversal. But without Valsalva, if the size is less than 2 millimeters, and the patient is asymptomatic, then it is considered normal for the person. If symptomatic, then surgical intervention is recommended.

I hope this has helped you.

Thanks and regards.

Patient's Query

Hello doctor,

Thanks for your reply.

Can you please let me know the impact on the sperm parameters like sperm count and mobility?

Please help.

Answered by Dr. Sameer Kumar

Hello,

Welcome back to icliniq.com.

The ultrasound Doppler for the scrotal area shows the presence of a 3-millimeter left epididymal cyst in your case. The presence of a left epididymal cyst indicates that there is a collection of cystic fluid in the epididymis which is basically the outlet of sperm ejaculation. If there is a collection in the tract, then it can cause outflow obstruction leading to decrease sperm counts in men.

If there would have been cysts on both sides, then there are chances that the patient may have azoospermia or no sperms in ejaculate. But the cyst does not hamper the ability of a male to have intercourse. However, it can definitely cause a decrease in sperm counts.

The remedy is surgical removal of the epididymal cyst but there are chances that there may be future production of epididymal cysts again. So that has to be kept in mind as there are no ways to actually prevent their recurrences.

I hope this has helped you.

Thanks and regards.

Patient's Query

Hello doctor,

Regarding the cyst, how will I know if there is a blockage in vas deference or not? It will show in which tests? Also, I ejaculate four to five ml of semen. I read less semen is ejaculated with blockages. In addition to this, per my ultrasound report, all my blood hormone levels are normal. What can we expect in sperm analysis? I am doing it next week. I am not overweight, not smoking and eat a lot of veggies and fruits at least four days a week. I have been taking the following supplements for the past three months:

  1. Taking Ashwagandha 650 mg daily.
  2. COQ 10.
  3. Multivitamins (C, zinc, selenium, lycopene, and E), etc.
  4. L-carnitine.
  5. Maca roots supplement in one tablet with food.

We have been trying for four months during the ovulation window no result yet. She has done transvaginal ultrasound and hormone tests, all normal. So either the problem is with me or maybe in her fallopian tubes. A doctor has not done a fallopian tube patency check; I do not think transvaginal ultrasound reveals that.

I am really worried about what semen analysis will reveal.

Thank you.

Answered by Dr. Sameer Kumar

Hello,

Welcome back to icliniq.com.

Blockages can cause a decrease in semen quantity, yes. But if only one is blocked, then it should not cause infertility as the other is open. Fallopian tube block can be checked with either hysterosalpingography or sonosalpingography. It is good to learn that you are taking supplements, and you may continue them. However, a semen analysis report would help us learn about your status.

Regards.

Patient's Query

Hello doctor,

What my urologist said about the cyst is that it is very common and normal, and it is very small, around three mm, which should not hamper fertility as it is present on the top head of the epididymis area. No treatment is required; he mentioned it is very unlikely it will impact numbers. I got a semen analysis done, which I am doing but based on my blood work (all the hormones are within normal limits). I am taking a good diet and multivitamins. The urologist also mentioned that no varicocele was present, which will cause any issues at the moment. There is no cyst present on the right side. I do not have any pain, and the volume is good. No pain or discomfort at this moment, so can you please let me know why such a cyst can cause low sperm counts?

Thank you.

Answered by Dr. Sameer Kumar

Hello,

Welcome back to icliniq.com.

If the epididymal cyst is not in the middle and not blocking the duct, then it would not cause any decrease in sperm count for the sperm coming from that side of the testes. As your cyst is at the head or tip so it really would not block the passage, and chances of low sperm count due to an epididymal cyst is unlikely in your case. You may get the semen analysis done and can follow up with reports.

Regards.

Patient's Query

Hello doctor,

Please find attached the report. What can be done to improve motility and morphology, and can it be improved? Why is there no value in progressive motility or even motility numbers? They just put motility at 20 %, and what are my options now?

Thank you.

Answered by Dr. Sameer Kumar

Hello,

Welcome back to icliniq.com.

Your report shows oligoasthenoteratozoospermia, which means low concentration per ml + slow-moving sperms + abnormal morphology of sperms. With abnormal forms of 98 percent and only 2 % normal sperms, the chances of conception are very low. Of the total sperms, only 20 percent are motile; the rest are immotile (which is depicted by no value in the report). One thing which they have not mentioned is if any pus or epithelial cells are seen in the semen, which indicates the level of infection in the semen and which can be the cause of such abnormal counts. You may get a semen culture and sensitivity as well to check for possible organisms causing the infection. Nevertheless, this is treatable and shall take a minimum of three months of treatment to restore sperm count and quality with medications. You may follow up with a video consult if you seek a prescription for medicines.

Regards.

Patient's Query

Hello doctor,

What do you think could be the cause of such a report, provided my ultrasound and blood hormone levels are normal? I am devatsed by this. So what can be done to improve motility and morphology? How can I know if there is any infection in my semen? I do not have any symptoms, so how can I know? What are my treatment options for IUI (intrauterine insemination)?

Thank you.

Answered by Dr. Sameer Kumar

Hello,

Welcome back to icliniq.com.

You would need to get a semen culture and sensitivity test done. The presence of sperm indicates that there is production. But the sperms produced are either subjected to an environment like an infection where they get deformed or a warm environment where the overall quality and morphology of the sperms are hampered. With the present reports, your next option would be an ICSI (intracytoplasmic sperm injection) procedure which is IVF (in vitro fertilization).

Thank you.

Patient's Query

Hello doctor,

As per my ultrasound, it seems normal. There is no sign of varicocele even with a valsva pressure. It is 2.5 mm (as discussed above), which should not cause such low numbers, right, even if we consider grade 1 varicocele? But my urologist said there is no varicocele. In addition to this why my report does not mention pus cells, so they might check it, and it is not present, so they did not mention it. I am trying to figure out the cause. If there is no varicocele, overweight, and unhealthy lifestyle so, what is the cause? I have worn boxers now for the last two weeks, and at night nothing to keep everything cool. It is hard to believe sperm count and motility, and morphology numbers are low. Can multivitaminslLike like COQ-10 help?

Thank you.

Answered by Dr. Sameer Kumar

Hello,

Welcome back to icliniq.com.

The causes can be multiple, and if no organic cause is established, then the reason remains genetic or stress-induced. The recovery of teratozoospermia will take 90 days as new sperms would develop under treatment with antibiotics followed by sperm energizers and multivitamins.

Regards.

Patient's Query

Hello doctor,

But what if there is no infection? Also, the sperm report says sperm is kept at 37 degrees Celcius. Is that normal? As I read, at that temperature, semen loses motility. Lastly, do you think this condition is reversible? I am taking multivitamins and CoQ10 200 mg daily with Ashwagandha 650 mg.

So regarding genetics, if that is the case, do you think it will have a normal impact on meat is normal? Usually, genetic causes will have a severe low count or no sperm in some conditions. Can I get a mini IVF (invitro fertilization)?

Thank you.

Answered by Dr. Sameer Kumar

Hello,

Welcome back to icliniq.com.

During the evaluation, the semen has to be liquified at room temperature. After checking the liquefaction time, the semen drop is mounted over the slide and then evaluated, so there are chances that sperms can become immotile, but not all. If they cannot cope with laboratory conditions, they will not be able to cope with the intravaginal environment. The fructose level in semen is also important as it is the food for sperm. Genetics cannot be commented upon unless screened, but it is unlikely in your case where sperms are produced but have turned abnormal and died. A mini IVF (invitro fertilization) is not an option. IVF ICSI (intracytoplasmic sperm injection) would be best for you.

Regards.

Patient's Query

Hello doctor,

In my report, there is no mention of fructose and pus cells. So should we assume they checked it but did not find so they did not mention it? The surprise is both morphology and motility numbers are half. I am going to continue with CoQ 10 and other supplements and make extra changes in lifestyle, so will that improve my numbers? Is that reversible? As you mentioned, 90 days?

Thank you.

Answered by Dr. Sameer Kumar

Hello,

Welcome back to icliniq.com.

They should have mentioned fructose - present or absent because, in the absence of fructose, sperms cannot survive long at all. Also, if seen, pus or epithelial cells should be commented upon at least by saying not present. The sperm energizers, CoQ 10, and multivitamins shall not work if an infection is present and we do not treat it first with a course of antibiotics. Once ruled out with culture sensitivity, then you can continue with the medicines for three months to seek a reversal. But without that, it would not be prudent on my part to suggest energizers and multivitamins blindly. This is treatable.

Regards.

Patient's Query

Hello doctor,

I think they mentioned debris in my report. It is mild, so no idea if that is epithelial cells or pus cells. I am also wondering why they did not mention fructose. I think it is better to get tested from different facilities as a few factors are not indicated in this report. In addition, regarding infection, how come I do not have any signs or symptoms like burning sensation or pain, etc.? There are no symptoms at all. Is that common?

Thank you.

Answered by Dr. Sameer Kumar

Hello,

Welcome back to icliniq.com.

The symptoms of burning micturition or pain in the penis or base of the penis are all usually associated with infection of the urinary tract - bladder or urethra but not the testicles. The symptoms of testicular infection manifest if the inflammatory reaction secondary to infection is more, and then it can present as painful testis or orchitis, or swelling in the testis. Nevertheless, a second repeat semen analysis with culture sensitivity would be a good idea to remove any bias. Also, prefer giving your sample after three days of abstinence from sex and ejaculation.

Regards.

Patient's Query

Hello doctor,

I spoke to the fertility clinic doctor, where I did the test. He said no round cells or white blood cells were noticed. So the sign of infection can be ruled out then? He mentioned that I have 31 million motile sperm if you look at the count per ejaculation. So he said even morphology and motility are on the lower side, but that can be improved by diet and some vitamins. Let us redo the analysis after three months of regular exercise, avoiding caffeine, smoking, and alcohol, and having plenty of fruits and vegetables. But he could not answer what is the cause behind such low numbers if an infection is not there and varicocele is not noted. I came in contact with no environmental toxins. It seems a mystery now to me, with 157 million counts with such low motility and morphology and unable to find the cause to correct it.

Thank you.

Answered by Dr. Sameer Kumar

Hello,

Welcome back to icliniq.com.

In that case, just repeat the semen analysis from a different laboratory and also get a culture sensitivity; maybe the present report is wrong. If no cause is found, the counts would ultimately be attributed to stress or idiopathic cause. In either case, the treatment line would not change for you.

Regards.

Patient's Query

Hello doctor,

So first treatment line would be to continue taking multivitamins and CoQ10 and L carnitine, Shilajith and Ashwagandha organic, and fenugreek supplements for at least the next two months. Then I am planning to repeat the semen analysis around the 75th day. I will consult my urologist to see if he can write a request for semen culture analysis. Lastly, I want to ask if this is treatable. If my motility increases up to 30 to 35 % and morphology to four to five percent from my current state, then I might opt for IUI because count and concentration are normal. After sperm preparation, they can take good-quality sperm to insert. She has done all tests, and everything is fine with her regarding regular ovulation. Can Clomid help me to get some improvements in the numbers? What do you recommend? Do tests in the next two weeks from different laboratories and see if they report any pus cells or not. That way, we can 100 % rule out that. And then, continue with the above regime for two to three months and then repeat the analysis. I am confused about whether to do the test again from a different laboratory in two weeks or wait for three months.

Thank you.

Answered by Dr. Sameer Kumar

Hello,

Welcome back to icliniq.com.

1. Please repeat the semen analysis again from another laboratory, as we would have two reference reports from different laboratories. Also, semen culture and sensitivity would be mandatory because in case we find an infection, then supplements and energizers would not be much helpful.

2. Clomid (Clomifene) can be held in the treatment, yes, and it is a part of treatment in different infertility regimens.

3. It is treatable as long as the testicles do not stop producing sperm at all. So have faith.

4. As far as supplements are concerned, you are on the right track and can use CoQ 10, L-carnitine, zinc, selenium, vitamin-D3, and Clomid, but in prescribed dosages to revive your sperm quality, but after a course of antibiotics as discussed.

Regards.

Patient's Query

Hello doctor,

Thank you for the reply. I will talk to my urologist tomorrow to see if he can write a requisition for semen culture analysis; as per the fertility clinic, they did not find any round cells, so there is no sign of infection. Secondly, what parameters would be ideal for IUI (intrauterine insemination) procedure? I mean, the total motility I got after three months of supplements to 30 to 34 %, and morphology to four to five percent. Will IUI be a good option, given the fact count is normal? Lastly, in my ultrasound report, there is mild dilation after the Valsva maneuver. Right, varicocele is 2.5 mm; before Valsva, it was 1.8 mm. So, such mild dilatation can cause such disastrous numbers in motility? Should I go for surgery to repair varicocele?

Thank you.

Answered by Dr. Sameer Kumar

Hello,

Welcome back to icliniq.com.

1. As there is no concrete evidence of infection, we can go with no infection, but I suggest culture sensitivity anyways.

2. Good motility is more than 80 %, and in abnormal forms, less than 4 %. With these parameters, the chances of IUI success can increase manifold if timed properly with ovulation.

3. I do not think surgery is required for the size of your varicocele.

Regards.

Patient's Query

Hello doctor,

So is the varicocele causing issues in motility parameters? If yes, then surgery can help. 80 % motility for IUI (intrauterine insemination) is a lot for natural conceiving. I am visiting a urologist tomorrow to find out the cause with semen culture analysis. I heard IUI is helpful when motility is on the lower side. Why does a person who has motility around 50 to 80 % need IUI? They can naturally conceive, as per WHO (World Health Organisation), provided everything else is normal.

Thank you.

Answered by Dr. Sameer Kumar

Hello,

Welcome back to icliniq.com.

Firstly, there are no yes and no facts about infertility. If one cause is contributory in one, the same cause may not be responsible in another man. So one has to treat every individual differently. There are men who, despite high motility and good counts, cannot conceive even naturally, as the chances of conception during each cycle are only 28 to 32 %. With IUI (intrauterine insemination), the cervical and the vaginal factors are removed, + rapidly progressive sperms are concentrated in a three ml post-wash sample (where, again, the count and quality matters), and even then, the success rates are between 38 to 43 % universally. So it is recommended that for idiopathic causes, the counts, quality, and motility should be improved first medically before opting for an IUI even. For understanding, there are cases where women got pregnant even naturally with poor sperm morphology. Still, the fetal heartbeat never arrived, or the case turned into a case of chemical pregnancy. So the WHO guideline is fine, and they recommend more than 40 percent rapidly progressive, but again, chances of success remain between 38 to 43 percent.

Regards.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Sameer Kumar
Dr. Sameer Kumar

Obstetrics and Gynecology

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