I am getting chest pain with tightness and shortness of breath while lifting heavyweight. Why?

Hello,

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Normally, RNP (ribonuclear protein) levels below 20 units on ELISA is negative. But if it is more than 26 units suggest positive. It is suggesting multiple connective tissue disorders like myositis, scleroderma, rheumatoid arthritis, etc.

PM-scl also suggest that scleromyositis. Signs may present like Raynaud's phenomenon, arthritis, myositis, and scleroderma. It may present like upper limb bluish discoloration on cold exposure, multiple joint pains, early morning stiffness, fever, muscle pain, dryness of the skin and even present like chest muscle spasm.

So your remaining reports appear normal only (attachment removed to protect patient identity). It may be non-cardiac pain and looks like muscular pain. But you may also get it done serum CPK (creatinine phosphokinase) levels, blood urea, serum creatinine, and if necessary muscle biopsy.

If it is treated with NSAIDs (nonsteroidal anti-inflammatory drugs) like Ibuprofen and Indomethacin it is muscular pain. If it is confirmed MCTD (mixed connective tissue disease) then it needs to be treated with steroids and anti-metabolites.

Hello,

Welcome back to icliniq.com.

Yes, usually, they may be false positive also why because the chances of U1 RNP got positive in SLE (systematic lupus erythematosus), rheumatoid arthritis, scleroderma, and Raynaud's phenomenon.

But in your case, remaining all are negative so more chances of false positive. In pregnancy, immunocompromised status patients may also present like false-positive results.

But we have to consider symptoms of the patient with remaining investigation together then will treat it. That is why I advised ESR (erythrocyte sedimentation rate), CRP (C-reactive protein) and muscle biopsy to confirm whether there is any inflammation in your body or muscle.

I hope this helps.