iCliniq logo

Ask a Doctor Online Now

HomeAnswersInternal MedicinehsvMy HSV 1 IgG value is 49.20. Does it mean the infection is a recent one?

My HSV 1 IgG value is 49.20. Why is it so high?


The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

Dr. Nithila. A

Published At June 16, 2019
Reviewed AtJanuary 19, 2024

Patient's Query

Hello doctor,

I took an STD panel test and got a positive result for HSV-1 IgG Ab test. My result was 49.20, but the reference range was 0.91 for negative and anything over 1.09 as positive. Does my 49.20 mean the infection is a very recent one because it is so high? I am confused about why it is so very high. Should it go down over time?

I have also heard that a high IgG could be related to HIV, as I was tested negative for it at day 105 after potential exposure (the last sexual encounter I had was three and a half months ago). Does an HSV IgG antibody test measure for antibodies that are only relevant to HSV, or should I be worried about HIV?

Answered by Dr. Sadaf Mustafa


Welcome to icliniq.com.

HSV (herpes simplex virus) IgG (immunoglobulin G) antibodies indicate previous exposure and HSV IgM (immunoglobulin M) indicates current disease. The positive IgG can become significant only if you have active lesions.

The type one usually causes oral lesions which look like small blisters. The HIV testing recommended post exposure is the PCR (polymerase chain reaction) or the fourth generation. Which testing did you get? If the antibodies are negative for three months out it is a good sign. But I would be satisfied if HIV by PCR is obtained. I hope I have answered your questions.

Patient's Query

Thank you doctor,

For HIV testing, I got a fourth generation test. Is it normal for someone who has had a past exposure to HSV-1 to have 49.20 was much higher than the reference range? Does this mean that the infection was there for a long time, or is it recent, or if other medical issues are causing the high number?

Answered by Dr. Sadaf Mustafa


Welcome back to icliniq.com.

No, you do not need to have an underlying infection for the HSV titers to go up. It can remain high and positive for years after the initial exposure. You may not even recall having a blister or a disease. The fourth generation HIV test is a good test, and it has both antigen and antibody testing.

Sometimes the HSV-1 can be acquired through sexual interaction, but mostly it is a non-sexual interaction. Like an affectionate mother kissing her child (who has HSV-1) having said that it could still happen. I would not worry much about the titers if you do not have active lesions both genital and oral. The HSV-2 is mostly sexually transmitted. I hope I have answered your questions. Take care

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Sadaf Mustafa
Dr. Sadaf Mustafa

Internal Medicine

Community Banner Mobile
By subscribing, I agree to iCliniq's Terms & Privacy Policy.

Read answers about:

hiv testingpcrhsv

Ask your health query to a doctor online

Internal Medicine

*guaranteed answer within 4 hours

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.

This website uses cookies to ensure you get the best experience on our website. iCliniq privacy policy