Q. My HSV 1 IgG value is 49. 20. Why is it so high?

Answered by
Dr. Sadaf Mustafa
and medically reviewed by Dr.Nithila A
This is a premium question & answer published on May 05, 2019

Hello doctor,

I took an STD panel test and got a positive result for HSV-1 IgG Ab test. My result was 49.20, but the reference range was 0.91 for negative and anything over 1.09 as positive. Does my 49.20 mean the infection is a very recent one because it is so high? I am confused about why it is so very high. Should it go down over time?

I have also heard that a high IgG could be related to HIV, as I was tested negative for it at day 105 after potential exposure (the last sexual encounter I had was three and a half months ago). Does an HSV IgG antibody test measure for antibodies that are only relevant to HSV, or should I be worried about HIV?



Welcome to icliniq.com.

HSV (herpes simplex virus) IgG (immunoglobulin G) antibodies indicate previous exposure and HSV IgM (immunoglobulin M) indicates current disease. The positive IgG can become significant only if you have active lesions.

The type one usually causes oral lesions which look like small blisters. The HIV testing recommended post exposure is the PCR (polymerase chain reaction) or the fourth generation. Which testing did you get? If the antibodies are negative for three months out it is a good sign. But I would be satisfied if HIV by PCR is obtained. I hope I have answered your questions.

Thank you doctor,

For HIV testing, I got a fourth generation test. Is it normal for someone who has had a past exposure to HSV-1 to have 49.20 was much higher than the reference range? Does this mean that the infection was there for a long time, or is it recent, or if other medical issues are causing the high number?



Welcome back to icliniq.com.

No, you do not need to have an underlying infection for the HSV titers to go up. It can remain high and positive for years after the initial exposure. You may not even recall having a blister or a disease. The fourth generation HIV test is a good test, and it has both antigen and antibody testing.

Sometimes the HSV-1 can be acquired through sexual interaction, but mostly it is a non-sexual interaction. Like an affectionate mother kissing her child (who has HSV-1) having said that it could still happen. I would not worry much about the titers if you do not have active lesions both genital and oral. The HSV-2 is mostly sexually transmitted. I hope I have answered your questions. Take care

Was this answer helpful?



This is a sponsored Ad. icliniq or icliniq doctors do not endorse the content in the Ad.

Also Read Answers From:

Comprehensive Medical Second Opinion.Submit your Case

Related Questions & Answers

How is the CMIA combo test done for HIV testing?

Query: Hello doctor, I shall be thankful to you if you please answer few of my queries. How CMIA combo for HIV testing is done? How much it is reliable at 175 and 180 post incidence. INDEX was .14 and .08, respectively. What are the chances of error in the result? (Done at two different labs). Even after ...  Read Full »

I am under PEP. How often should I get tested for HIV if the results come negative?

Query: Hi doctor, I am 32 years old. I am on PEP that has to be taken for 28 days. I got my first dose around 40 hours of being contracted to HIV. PEP is not 100 % secure. My question is if I am lucky and the result shows HIV negative after the therapy, how often do I need to get antibody tested if luck s...  Read Full »

HSV IgM tested on tongue came negative. Need a second opinion. Is there any Suggestions?

Query: Hello doctor, My brother had one blood test with herpes simplex IgM diagnosed to be negative, but herpes type 1 was diagnosed to be positive with an index more than 8. Before that he did a test on his tongue and it was negative for herpes. Are these results final? Or is there a chance that he is n...  Read Full »

Also Read

I get twitches on my calves, shoulders, and head after getting the Novavax COVID vaccine. Please help.
Hello doctor, I got the Novavax COVID vaccine. Since I had the vaccine, I had bad arm pain. But the scary thing that ha...  Read more»
It hurts when I push above my left breast bone. Please help.
Hi doctor, I have been having some chest pain issues. When I push above my left breast bone it hurts in only one spot. ...  Read more»
Bird Flu (Avian Influenza) - Causes, Symptoms, Mortality Rate, and Treatment
Bird flu or avian influenza is a viral infection that spreads among birds and can affect humans rarely. Read the article...  Read more»

Ask your health query to a doctor online?

Ask an Internal Medicine Physician Now

* guaranteed answer within 4 hours.

Disclaimer: All health Q&As published on this website are not intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek the advice from your physician or other qualified health-care providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website.