I get burning sensation while passing urine with frequent urination at night. Please help.

Hello doctor,

I have a burning sensation while passing urine, and I get frequent urination at night. My USG abdomen and pelvis shows, prostate is enlarged in size and measures 80-90 cc in volume, median lobe of prostate is seen projecting into the bladder base, visualized bowel loops are non-dilated and show normal peristalsis, no ascites is noted, urinary bladder (UB) is well distended, UB wall is normal, no visual calculus are seen, pre void volume is 725 cc, post void volume is 90-100 cc - significant, and my HbA1c is 5.5 %. My present problem is burning sensation in the urinary bladder and urethra until the exit point.

I was on the following medications for about a month now which includes, Norflox 400 1-0-1, Levofloxacin 750 1-0-0, Potrate MB6 10-10-10 ml, Tamsulosin 0-0-1, Pulmocef 500 1-0-1, and Cystone forte 1-0-1. Urine routine test shows, colour - pale yellow, specific gravity - 1.015, appearance - clear, pH - 6.00, urobilinogen - normal, epithelial cells - 1-2, pus cells - 0 - 1, RBC, carts, crystals, budding yeast cells, bacteria - absent, and leucocytes, urine protein, ketone, nitrile, urine glucose, bile pigments, blood, and bile salts - negative. Urine culture shows occasional pus cells. No org seen, pus cells, epithelial cells, RBC counts based on direct uncentrifuged specimen centrifuge sediment. Blood test shows, PSA-2.18, and sugar PP-141.

I have burning in urethra and glans region, which starts in the morning and remains until evening. I also have burning while passing urine and frequent urination at night. And I do not get sleep after 02.30 AM. Kindly help.