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Koplik spots of Pre-Measels - Appearance, Significance, and Manifestations

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Koplik's spots are small, bluish-white patches that appear in the early stages of measles. Read the article to understand more.

Medically reviewed by

Dr. Shubadeep Debabrata Sinha

Published At August 7, 2023
Reviewed AtAugust 8, 2023

What Are Koplik’s Spots in Measles?

The name "Koplik spot" was coined in 1896 by Dr. Henry Koplik of New York. These spots are slightly elevated bluish-white spots with a two to three-millimeter diameter in the oral cavity's buccal mucosa opposite the first tooth. They appear as a pre-eruptive symptom of measles or rubeola. Koplik spots are frequently described as "grains of salt on a crimson background." The white area is presumably the result of glandular epithelial cell death, whereas the bluish appearance is brought on by a collar of dilated veins surrounding the submucosal gland duct. They can also appear in other places, such as the conjunctival fold, soft palate, and vaginal or intestinal mucosa, and persist for two to three days.

How Do Koplik’s Spots Appear?

Measles patients have bluish-white, slightly elevated Koplik spot lesions (diameter, two to three millimeters), which normally occur one day before the rash begins and last two to three days. When the skin eruption occurs, the mucosa loses its unique appearance. Instead, it becomes a diffuse red background with numerous bluish-white particles. In a few days, the mucosa returns to its normal look. Measles is a highly contagious viral respiratory illness causing rashes on the entire body and flu-like symptoms. It is a widespread disease affecting millions of children each year around the world. Unfortunately, there is no specific medical treatment for it. Instead, the infection must be allowed to take its course. To avoid spreading the virus, a sick child should drink enough fluids, get plenty of rest, and stay home from school or daycare.

Prodromal Manifestations

  • Cough.

  • Runny nose.

  • High fever.

  • Red eyes.

  • Koplik’s spot.

  • Rash.

The rash appears three to five days after the symptoms begin, frequently in conjunction with a high fever temperature. The red or reddish-brown rash commonly starts as flat red dots on the brow. Next, it travels down the neck and body to the arms, legs, and feet, then to the remainder of the face. In a few days, the fever and rash fade.

Do Measles Spread to Others?

  • Measles is extremely contagious. Nine out of ten persons not immunized for measles will contract it if they contact an infected person.

  • Measles spreads when a person inhales the virus-infected fluid or comes into close contact with it.

  • Individuals with weakened immune systems due to other illnesses, such as human immunodeficiency virus (HIV), can spread the measles virus until they recover.

  • It can spread through droplets sprayed when a measles patient sneezes or coughs. Symptoms usually appear seven to 14 days after being infected with the virus.

  • Individuals with measles can spread the disease from four days before the rash appears until four days after the rash appears.

  • They are most contagious with a fever, runny nose, and cough.

What Is the Importance of Koplik’s Spots?

Measles is common in childhood worldwide. The World Health Organization recommends several vaccine regimens to combat measles. However, certain nations have reduced coverage for economic and political reasons and vaccine safety concerns. Early diagnosis is critical to limit its spread. Koplik spots are important not only for diagnostic purposes but also for suppressing measles outbreaks.

What Is the Treatment for Kopliks Spot?

Children with measles should be isolated after their rash starts, as the infection might linger for several weeks. Those with a weakened immune system should continue to do so until they have fully recovered and all symptoms have subsided. Measles has no specific medical therapy. However, to assist with symptom management:

  • Drink plenty of fluids.

  • Rest.

  • Fever medications (Paracetamol).

Aspirin should never be given to a child suffering from a viral illness, as it has been associated with Reye syndrome. A doctor should regularly monitor children who have measles. In some circumstances, measles can cause complications.

  • Vaccines - It is the greatest method to safeguard children against measles. Most children receive measles protection when they are 12 to 15 months old and again when they are four to six years old as part of the following:

  • Measles-mumps-rubella (MMR).

  • Measles-mumps-rubella-varicella (MMRV) vaccine.

Due to widespread vaccination, measles is becoming less common in the United States. Yet, outbreaks keep happening. When a disease spreads more widely than expected in a particular location, it is called an epidemic. The lack of immunization has been a major factor in increasing measles epidemics worldwide. The vaccination must be administered promptly to all eligible youngsters. Those at risk, such as those with compromised immune systems, cannot receive the vaccine. But when many individuals receive immunization against a disease, it protects them, prevents the illness from spreading, and helps control outbreaks.

What Is the Differential Diagnosis for Koplik’s Spot?

The other conditions resembling Koplik’s spot are as follows:

  • Fordyce granules (lack a bright red background).

  • Parvovirus B19 infection.

  • Aphthous ulcers (painful and less numerous).

differential-diagnosis-for-kopliks-spot

What Are the Complications of Measles?

The complications of measles are as follows:

  • Pneumonia.

  • Ear infections.

  • Encephalitis (irritation and swelling of the brain).

  • Diarrhea.

Conclusion

Measles can be prevented if it is recognized early by recognizing Koplik spots. These spots appear on the inside of the cheeks early in the course of measles and are small, white spots, frequently with a reddish backdrop. As a result, early detection aids in controlling this highly infectious disease by allowing for immediate care and control measures for measles. As a result, the individual should be informed about the early indications of measles, such as Koplik spots, and the protocols to be followed if measles is detected. Thus, getting vaccinations and preventing the disease from spreading, it is also vital to physically inspect the child for measles symptoms and assess the family's hygiene standards.

Dr. Shubadeep Debabrata Sinha
Dr. Shubadeep Debabrata Sinha

Infectious Diseases

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