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What are the confirmatory tests for HIV?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

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Published At July 7, 2018
Reviewed AtApril 19, 2024

Patient's Query

Hi doctor,

I want to tell my case and I would appreciate a detailed answer on this subject. About five months ago, I had sex with a CSW (community sex worker) during a vacation. The relationship included oral sex and vaginal sex. The relationship was completely protected (also oral) and I put on a condom (I do not know if it got broken). After two days of the incident, I noticed a small red bloodbath on my scrotum, which later grew (the skin doctor diagnosed it as an angerectomy). After about two weeks after the incident, I began to have severe pain in the legs and feet that have gone and are still coming today randomly. In addition, 10 days after the incident, my temperature rose to 37.5 for about a month and a half. After a month or so, I started to get a lot of wounds in my chest, shoulders, and back (the dermatologist diagnosed it as a folliculitis). These wounds are coming and going today. In addition, many small red dots (about 50 to 60) have begun to appear on the skin especially in the chest and arms to this day, more and more news appears (the skin doctor claimed to be hemangiomas). It looks like a little blood blister. Also I suffer from severe dehydration in the skin and palms for a long period of three months, there is really a white layer of dryness and even hand cream does not help. Lately, I have also realized that my tongue always feels dry and the color is white with a little white bump in the end. I have lost weight about 5 kg for a period of two months. In addition, strong head pain that comes and goes and a painkiller does not help at all, and also suffers from fatigue all the time. I have done a lot of testing of HIV combo Ag-Ab, fourth generation, and all were negative. In addition, two weeks ago (four and a half months of the case), I tested Hepatitis B and C (negative result). As well as an antibody test for syphilis SCR by ELISA (negative result). In addition to the above, about a week after the incident, I began to feel a stab at the end of the penis, and I also had a feeling of burning at the end of urination. I have done many urine tests that include PCR from urine for chlamydia, gonorrhea, trichomoniasis, mycoplasma and/or plasma several times, all of which returned negative. About two months ago, I started a transparent discharge from the end of the penis. I repeated the tests, negative, also a general urine test without findings (no leukocytes) and urine culture returned without findings. Here are the questions: Have the tests I performed and returned negative throughout the period clearly indicate that I have not contracted HIV from the case described? Can there be a case in which the virus is not detected and more time is required for further testing? If so, when to do it? In light of all the symptoms I have described, what can it be? What more can be checked that expresses itself in such a way? Are light symptoms recommended to perform a different method test like PCR for example? Has the combo test detected HIV (Human Immunodeficiency Virus) types 1, 2, O? Does the test detect all sub-types and all strains of the virus? Can it be that I have HIV 2 and the test cannot detect antibodies because it can take a longer time? I read that sometimes in rare cases it can take a year to detect enough antibodies and before that all the test will be a false negative, is that really possible? Is there anything new that has emerged in the medical literature at this time that figured out from what all I have said?

Answered by Dr. Sushil Kakkar

Hello, Welcome to icliniq.com.

I have viewed the images (attachment removed to protect patient identity). Your screening tests for HIV are conclusive Your screening tests for HIV are conclusive. A three months intervening period between risk exposure and HIV screening tests (fourth generation HIV antigen-antibody combo test and third-generation HIV antibody screening test) is considered enough for a test to be considered conclusive. There is no need to do another type of test. The combo test is suited to the strains, types and subgroups of HIV prevalent in a particular area and therefore unlikely to miss HIV strain, type or subgroup. HIV 2 can be detected by a combo test and it has the same window period (three months) as it has for HIV 1. Delayed seroconversion is only possible in case of immunosuppression like organic transplant recipients or those on oral steroids. Not otherwise. Your tongue looks normal. The little white bumps, in the end, are circumvallate papillae which are quite normal. The bumps on chest and shoulders are perhaps acne rather than folliculitis whereas the red dots are perhaps cherry angiomas. However, I request you to kindly upload a few more good quality images of the affected areas so that I am able to confirm and guide you better.

Patient's Query

Hi doctor, Thanks for the quick response.

First of all, I was pleased to receive from you an answer that the tests I did on HIV were indeed conclusive. I must note, however, that I never suffered from acne (not even in adolescence) and never suffered from any skin symptoms. I feel that since the incident I have a lot of strange symptoms (as I mentioned in the previous post). And do not understand what is going on with my body. The red dots e mostly in the chest and hands, and as I have one on the scrotum, when I press them they disappear for a second and then again fill with blood so I guess it is a lot of small blood blisters. I never had them and they started to emerge after the incident. What can this be caused by? And why do not I stop getting more and more red spots. The severe dryness of my palms appears mainly that I wake up in the morning there is really dandruff on the skin and a white layer of dryness. Sometimes I suffer from night sweats, so I wake up that my shirt is wet with sweat. I have pain in my feet and my legs. It is very random, that is, you can get a week and disappear and then come back again. I have a bothersome irritation in the penis crown especially on the left side for a long time and it does not pass. You said about the combo test that the strains and types of the virus are adapted to the area where I live. I do not know if the test in my country includes the strains and types that are there as well. How can I count 100 percent on test results? For the chest and shoulder wounds, the dermatologist diagnosed it as a polycolitis because there is a white spot at the end of the wound, I tried drugs like Minocycline and Cotrimoxazole but without benefit. The wounds come and go all the time. I have been suffering from severe back pain in the lower back on the left. It has started a week ago. There are red peels in the scalp (treated using the Mometasone cream). A month and a half ago I got up in the morning with swelling on the right side of the face and a feeling of burning in the skin on the right side of the face. It passed two days later and after a week and a half the sensation returned, it really came in fits, my facial skin on the right side became red with a feeling of burning and tingling, the phenomenon I describe comes and goes to this day. I did an ultrasound but nothing unusual discovered. Can I be 100 percent sure that I have not infected HIV with all its strains and species? I really worry because of all the symptoms. Do you know of similar cases of people who have symptoms similar to mine and have at the end of the diagnosis what exactly they have? Could it be a disease or other infection transmitted through sexual contact and cause all of this? Do you think it is necessary to perform a screen test for HTLV (Human T- Lymphptrophic Virus) 1/2? I do not know if there is any connection between my symptoms.

Answered by Dr. Sushil Kakkar

Hi, Welcome back to icliniq.com.

Routine HIV tests which are currently being used for blood screening and diagnostic purposes detect virtually all subtypes of the human immunodeficiency virus. The red spots are actually cherry angiomas. They are benign and have nothing to do with your sexual contact. They are just a cosmetic issue. They need to be either fulgurated with electrocautery or vaporized with a laser. The bumps on your chest are inflammatory acne, red papules, and pustules. Not folliculitis. You may use topical Benzoyl Peroxide 2.5 % to 5 % gel, twice daily or a Benzoyl Peroxide body wash. Use an intensive moisturizer like urea or lactic acid-based moisturizer for your palms. The corona of the glans on the left side seems a little inflamed and eczematous. I suggest you use a topical steroid like Cortisone cream or Triamcinolone acetonide 0.1 % cream, twice daily. None of these are specific signs or symptoms of HIV. Moreover, the nature of your sexual contact does not pose any risk of HIV.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Sushil Kakkar
Dr. Sushil Kakkar

Dermatology

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