Do increased levels of RBC and vitamin B12 indicate early onset polycythemia vera?

Hi,

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I appreciate your knowledge and awareness towards your health, and I have seen your reports (attachment removed to protect patient identity).

1. Your vitamin B12 level is certainly high, enough that warrants further investigation. Following are the common causes for high vitamin B12 level.
2. Excess intake of vitamin B12 supplement.
3. Any liver disorder.
4. A myeloproliferative disease like polycythemia or CML (chronic myeloid leukemia).
5. Any cancer and kidney disease.
6. Now as your RBC (red blood cells) are elevated, first of all, polycythemia vera comes in mind, but normal hemoglobin and hematocrit levels are against the diagnosis of it. Regular screening should be done up to one year at least, if hematocrit and hemoglobin are increasing, then JAK 2 mutation study can be done for its confirmation.
7. In myeloproliferative disorder, WBC (white blood cells) count is usually high which is normal. If in screening, the WBC count is increased, then it can be confirmed by BCR-ABL t(9;22) study by molecular testing.
8. Evaluate liver functions by serum SGPT (serum glutamic pyruvic transaminase), SGOT (serum glutamic oxaloacetic transaminase), serum albumin and ultrasound. Kidney function test also should be evaluated with serum creatinine and serum urea like investigations.
9. Avoid alcohol. Consult a nearby physician for examination and regular screening. If no cause is found in subsequent follow-up, and vitamin B12 level comes to normal, then it might be elevated because of papillary carcinoma history.