Progyluton Pill - Usage, Contraindications, Side Effects, and Overdosage

What Is Progyluton Pill and How Does It Work?

Progyluton tablet is a hormonal combination drug. Norgestrel and Estradiol valerate is the active ingredients in these tablets. This hormone combination medicine aims to prevent pregnancy (contraception). It contains both estrogen and progestin hormones.

In addition to preventing conception, birth control tablets may also improve acne, reduce blood loss during periods, lessen uncomfortable cramping or menstrual pain, decrease the risk of ovarian cysts, make periods more regular, and control pre- and post-menopausal symptoms.

This drug does not offer protection from sexually transmitted diseases or STDs (such as HIV [human immunodeficiency virus], gonorrhea, or chlamydia). Progyluton pills function by boosting the pituitary's release of gonadotropins, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH), connecting to nuclear receptors in tissues that respond to estrogen, and altering cervical and uterine mucus to prevent egg and sperm union.

What Are the Uses of Progyluton Pill?

Progyluton tablet is used to treat, manage, prevent, and improve the symptoms of the following illnesses and conditions-

• To reduce the discomfort and blood loss caused by certain menstruation disorders.

• To manage signs and symptoms of menopause as a hormone replacement therapy (HRT).

• To avoid pregnancy (as a contraceptive pill).

• Menopause-related vaginal atrophy and vulvar atrophy.

• Hypogonadism-related hypoestrogenism.

• Advanced prostate cancer that is androgen-dependent

• Primary ovarian failure.

How to Use Progyluton Pill?

• Eleven white tablets of 2 mg Estradiol valerate each, along with ten light brown tablets of 2 mg Estradiol valerate and 0.5 mg Norgestrel each, are included in a calendar pack (blister pack).

• This medication must be used orally. This pill must be swallowed whole with water, not chewed, crushed, or broken. If this drug is prescribed daily, it is best to take it at a certain time each day.

• Progyluton is a cyclic hormone replacement therapy (HRT) medication. For 21 days, one pill should be taken orally once each day. Then, there should be a seven-day break from tablets. As a result, each new pack is initiated after a cycle of 28 days.

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• The white tablets should be taken from day one to day 11.

• The brown tablets should be taken from day 12 to day 21 after the white ones.

What Are the Contraindications for Progyluton Pill?

Progyluton pill must be avoided in the following conditions-

• Hypersensitivity or allergy to any of the active or inactive ingredients.

• Breast cancer (present or suspected).

• A premalignant or malignant condition that is sex hormone-dependent.

• Endometrial hyperplasia (untreated).

• Vaginal bleeding that is unclear.

• Benign or cancerous hepatic tumors, either current or past.

• If the liver function results have not returned to normal, significant liver problems. (including those in the medical history) maybe present.

• Any venous thromboembolic incidents, recent or old (e.g., deep vein thrombosis, pulmonary embolism).

• Recent or acute arterial thrombotic incidents (cerebral or myocardial infarction).

• Existence of arterial or venous thromboembolic event risk factors (e.g., antithrombin, protein S, or protein C deficiency).

• Severe hypertriglyceridemia.

• Porphyria.

• Lactating mother.

• Pregnancy.

• Children (not indicated before menarche).

What Are the Side Effects of Progyluton Pill?

Before taking the Progyluton tablet, the patient must disclose to the physician all of their current prescriptions, over-the-counter drugs (such as vitamins, herbal supplements, etc.), allergies, and existing medical conditions (e.g., pregnancy, upcoming surgery, etc.). They may be more susceptible to the drug's side effects due to certain medical issues.

The potential negative effects of each component that makes up the Progyluton tablet are listed below-

• Headache.

• Hair loss.

• Itches.

• Vaginal bleeding, spotting, and vaginal infections (vaginitis).

• Irregular periods.

• Increased weight.

• Rashes and yellowing eyes or skin.

• Abdominal cramps.

• Tiredness and dizziness.

• Mood changes or depression.

• Nausea and vomiting.

• Dysmenorrhea.

• Hypertension (increased blood pressure).

• Pulmonary embolism

• Cholestatic jaundice.

• Pruritus.

• Stomach cramping and bloating.

• Breast lumps, tenderness, and a decrease in breast size.

• Other severe conditions like- ovarian cancer, endometrial hyperplasia, endometrial cancer, breast cancer, stroke, migraines, dizziness, or fainting.

What Are the Drug Interactions of Progyluton Pill?

The effects of Progyluton tablet may alter if other medications or over-the-counter medicines are taken concurrently. The following medicines and products and the Progyluton tablet may interact:

• Carbamazepine.

• Acitretin.

• Clarithromycin.

• Isotretinoin.

• Erythromycin.

• Ketoconazole.

• Phenobarbital.

• Itraconazole.

• Rifampin.

What Happens in Overdosage of Progyluton Pill?

The recommended dosage should not be exceeded. People should be aware that taking additional medication will not disappear their symptoms; instead, it could poison them or have other negative side effects. Anyone who suspects they may have taken too much Progyluton tablet must go to the emergency room of the nearest hospital or care facility.

Conclusion:

Progyluton treats various conditions, including advanced androgen-dependent prostate cancer, primary ovarian failure, vulvar and vaginal atrophy associated with menopause, hypoestrogenism caused by hypogonadism, and vasomotor symptoms associated with menopause. It has several limitations, adverse effects, and drug interactions that must be considered. To prevent withdrawal symptoms, the medicine should not be abruptly stopped. Before stopping them, the patient must have the doctor's approval.