Drug and Supplements Data Verified

Progyluton Pill - Usage, Contraindications, Side Effects, and Overdosage

Published on Dec 02, 2022   -  4 min read


Progyluton is a hormonal combination medication commonly used for contraception, menstrual irregularities, and abnormal uterine bleeding. Read to know more.

What Is Progyluton Pill and How Does It Work?

Progyluton tablet is a hormonal combination drug. Norgestrel and Estradiol valerate is the active ingredients in these tablets. This hormone combination medicine aims to prevent pregnancy (contraception). It contains both estrogen and progestin hormones.

In addition to preventing conception, birth control tablets may also improve acne, reduce blood loss during periods, lessen uncomfortable cramping or menstrual pain, decrease the risk of ovarian cysts, make periods more regular, and control pre- and post-menopausal symptoms.

This drug does not offer protection from sexually transmitted diseases or STDs (such as HIV [human immunodeficiency virus], gonorrhea, or chlamydia). Progyluton pills function by boosting the pituitary's release of gonadotropins, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH), connecting to nuclear receptors in tissues that respond to estrogen, and altering cervical and uterine mucus to prevent egg and sperm union.

What Are the Uses of Progyluton Pill?

Progyluton tablet is used to treat, manage, prevent, and improve the symptoms of the following illnesses and conditions-

  • To reduce the discomfort and blood loss caused by certain menstruation disorders.

  • To manage signs and symptoms of menopause as a hormone replacement therapy (HRT).

  • To avoid pregnancy (as a contraceptive pill).

  • Menopause-related vaginal atrophy and vulvar atrophy.

  • Hypogonadism-related hypoestrogenism.

  • Advanced prostate cancer that is androgen-dependent

  • Primary ovarian failure.

How to Use Progyluton Pill?

  • Eleven white tablets of 2 mg Estradiol valerate each, along with ten light brown tablets of 2 mg Estradiol valerate and 0.5 mg Norgestrel each, are included in a calendar pack (blister pack).

  • This medication must be used orally. This pill must be swallowed whole with water, not chewed, crushed, or broken. If this drug is prescribed daily, it is best to take it at a certain time each day.

  • Progyluton is a cyclic hormone replacement therapy (HRT) medication. For 21 days, one pill should be taken orally once each day. Then, there should be a seven-day break from tablets. As a result, each new pack is initiated after a cycle of 28 days.

  • The white tablets should be taken from day one to day 11.

  • The brown tablets should be taken from day 12 to day 21 after the white ones.

What Are the Contraindications for Progyluton Pill?

Progyluton pill must be avoided in the following conditions-

  • Hypersensitivity or allergy to any of the active or inactive ingredients.

  • Breast cancer (present or suspected).

  • A premalignant or malignant condition that is sex hormone-dependent.

  • Endometrial hyperplasia (untreated).

  • Vaginal bleeding that is unclear.

  • Benign or cancerous hepatic tumors, either current or past.

  • If the liver function results have not returned to normal, significant liver problems. (including those in the medical history) maybe present.

  • Any venous thromboembolic incidents, recent or old (e.g., deep vein thrombosis, pulmonary embolism).

  • Recent or acute arterial thrombotic incidents (cerebral or myocardial infarction).

  • Existence of arterial or venous thromboembolic event risk factors (e.g., antithrombin, protein S, or protein C deficiency).

  • Severe hypertriglyceridemia.

  • Porphyria.

  • Lactating mother.

  • Pregnancy.

  • Children (not indicated before menarche).

What Are the Side Effects of Progyluton Pill?

Before taking the Progyluton tablet, the patient must disclose to the physician all of their current prescriptions, over-the-counter drugs (such as vitamins, herbal supplements, etc.), allergies, and existing medical conditions (e.g., pregnancy, upcoming surgery, etc.). They may be more susceptible to the drug's side effects due to certain medical issues.

The potential negative effects of each component that makes up the Progyluton tablet are listed below-

  • Headache.

  • Hair loss.

  • Itches.

  • Vaginal bleeding, spotting, and vaginal infections (vaginitis).

  • Irregular periods.

  • Increased weight.

  • Rashes and yellowing eyes or skin.

  • Abdominal cramps.

  • Tiredness and dizziness.

  • Mood changes or depression.

  • Nausea and vomiting.

  • Dysmenorrhea.

  • Hypertension (increased blood pressure).

  • Pulmonary embolism

  • Cholestatic jaundice.

  • Pruritus.

  • Stomach cramping and bloating.

  • Breast lumps, tenderness, and a decrease in breast size.

  • Other severe conditions like- ovarian cancer, endometrial hyperplasia, endometrial cancer, breast cancer, stroke, migraines, dizziness, or fainting.

What Are the Drug Interactions of Progyluton Pill?

The effects of Progyluton tablet may alter if other medications or over-the-counter medicines are taken concurrently. The following medicines and products and the Progyluton tablet may interact:

  • Carbamazepine.

  • Acitretin.

  • Clarithromycin.

  • Isotretinoin.

  • Erythromycin.

  • Ketoconazole.

  • Phenobarbital.

  • Itraconazole.

  • Rifampin.

What Happens in Overdosage of Progyluton Pill?

The recommended dosage should not be exceeded. People should be aware that taking additional medication will not disappear their symptoms; instead, it could poison them or have other negative side effects. Anyone who suspects they may have taken too much Progyluton tablet must go to the emergency room of the nearest hospital or care facility.


Progyluton treats various conditions, including advanced androgen-dependent prostate cancer, primary ovarian failure, vulvar and vaginal atrophy associated with menopause, hypoestrogenism caused by hypogonadism, and vasomotor symptoms associated with menopause. It has several limitations, adverse effects, and drug interactions that must be considered. To prevent withdrawal symptoms, the medicine should not be abruptly stopped. Before stopping them, the patient must have the doctor's approval.

Article Resources

Last reviewed at:
02 Dec 2022  -  4 min read




Comprehensive Medical Second Opinion.Submit your Case

Related Questions & Answers

What are the precautions to be taken for bicornuate uterus pregnancy?

Query: Hello doctor, My wife is 30 years old and pregnant. This is our first child. We got married four years ago. She got pregnant soon after. But, since we were not ready, we opted for a termination of the pregnancy using a medicine. Now, my wife had undergone a pelvic ultrasound. She has been given thr...  Read Full »

Is vaginal pressure normal in a five weeks pregnant woman?

Query: Hello doctor, I am five weeks pregnant. I have mild cramping in my lower abdomen and no other symptoms. Sometimes. I feel vaginal pressure like menstruation. Do I have any problem, or is it normal? Please advise me on what to do.  Read Full »

My pregnant wife passed a little blood. Is it a sign of miscarriage?

Query: Hello doctor, My wife tested positive for pregnancy four weeks ago. Three days later, she was passing a little blood. Is that normal or is there a chance of miscarriage? Is Progesterone 200 mg a good tablet or is it because of this tablet that she is passing blood? Please advice.  Read Full »

Popular Articles Most Popular Articles

Do you have a question on Progyluton Pill or ?

Ask a Doctor Online

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.