Drug and Supplements

Meprate 10 MG Tablet

Written by Dr. K Sneha and medically reviewed by Richa Agarwal

 
Image: Meprate 10 MG Tablet

Contents


Overview:

Meprate is a progestin (a form of progesterone), which is used as a contraceptive pill. It inhibits ovulation by inhibiting LH surge and follicular development. Meprate is used to regularize the menstrual cycle as it has progestin, which is a form of the hormone progesterone. Progesterone is responsible for the shedding of the endometrium (inner lining of the uterus) during menstruation, so it is also used to prevent thickening of the endometrium. It is also used in a higher dose as a contraceptive.

Composition:

Medroxyprogesterone acetate is the progestin that is found in Meprate tablets. It is available as 2.5 mg, 5 mg, and 10 mg tablets, which is taken orally. It is the synthetic form of progesterone hormone. If the body lacks natural progesterone, then this tablet is used to replace it.

Uses:

Medroxyprogesterone is used to:

  • Prevent thickening of the inner lining of the uterus (endometrial hyperplasia). As a result, prevents cancer from developing in the uterus.
  • Reduce symptoms of menopause like hot flush (Hormone Replacement Therapy).
  • Stop abnormal bleeding from the uterus.
  • Induce periods in women having amenorrhea (absence of periods).
  • As a contraceptive.

Medroxyprogesterone acetate prevents pregnancy by preventing the proper development of ovum by reducing the secretion of Gonadotropin-releasing hormone (GnRH) from the hypothalamus. It also increases the mucus secretion in the cervix, making it hard for the sperm to reach the egg.

Endometrial hyperplasia is the thickening of the endometrium due to more estrogen in the absence of progesterone. Due to the lack of progesterone, the uterine lining keeps getting deposited because of estrogen. In such a case, progestin helps shed the endometrium and prevents its thickening. Endometrial hyperplasia may lead to uterine cancer.

Dosage:

Meprate is available as a 2.5 mg, 5 mg, and 10 mg tablet. The dosage varies according to the condition you are using it for, so it is essential to consult your doctor before taking this medicine. For example,

1. For abnormal or irregular menstrual bleeding or amenorrhea: The usual dosage is 5 or 10 mg daily for 10 days, starting from the 16th day of the menstrual cycle.

2. For endometrial hyperplasia prevention: 5 or 10 mg every day for 12 to 14 consecutive days every month.

The tablet should be taken as a whole, without crushing or chewing it. For best results, it should be taken at a fixed time every day. In case you forget to take a dose, take the next dose when you remember. If it is already time to take the next dose, then do not take the missed dose. It is not advisable to double the doses.

Overdose:

This tablet should not be taken more than the prescribed dosage. The overdose of progestin may cause nausea, vomiting, stomach pain, dizziness, tiredness, withdrawal bleeding, etc. If these symptoms occur, stop taking this medicine.

Substitutes:

1.Tablet Deviry.

2.Tablet Provera.

3.Tablet Medolin.

4.Tablet Regeeva.

5.Tablet Medrogest.

6.Tablet Modus.

Contraindications:

Medroxyprogesterone acetate should be avoided in the following conditions:

  • Vaginal bleeding of unknown cause.
  • Impaired liver function.
  • Pregnancy.
  • Uncontrolled diabetes.
  • Uncontrolled hypertension.
  • History of mental illness or depression.
  • Allergic to Medroxyprogesterone.

Drug Warnings and Precautions:

It is important to inform your treating doctor about any pre-existing health condition or any allergy. Medroxyprogesterone acetate should be avoided or taken with precaution if you have any of the following condition:

• While on this tablet, if you feel chest pain, dizziness, shortness of breath, headache, pain in the groin, and slurred speech, get medical assistance right away. This is because the tablet increases the risk of heart disease and stroke.

• It might cause pancreatitis (inflammation of the pancreas). Inform the doctor immediately if you develop severe abdominal pain, fever, chills, nausea, vomiting, etc.

• If you are pregnant or suspect pregnancy, then stop the drug and inform your doctor, as it can affect the fetus.

• Smoking should be avoided, as it increases the risk of stroke.

• The risk of heart disease is high if you are obese, diabetic or have high cholesterol.

• There is also a risk of blood clots, heart attack, stroke, breast and uterine cancer with this drug.

Tell your doctor if you have a history of any heart disease, stroke, blood clots, cancer, asthma, diabetes, epilepsy, hypertension, kidney disease, liver disease or any thyroid problem. Some precautions and dosage might need to be altered depending on the condition.

Drug Interactions:

Certain drugs that you are already taking might interact with this medicine and increase or decrease the effectiveness of the drug or cause side effects. The drugs that might interact with Meprate are:

1.Aminoglutethimide.

2.Rifampin.

3.Itraconazole.

4.Tranexamic acid.

5.Phenytoin.

6.Phenobarbital.

7.Isotretinoin.

8.Warfarin.

9.Ritonavir.

10.Cyclosporine.

Side Effects:

The following side effects may occur while taking this tablet:

  • Nausea
  • Vomiting.
  • Abdominal cramps.
  • Mood swings.
  • Dizziness.
  • Headache.
  • Decrease urine output.
  • Pain in the breast.
  • Depression.
  • Puffy eyes.
  • Weakness.
  • Weight gain or loss.
  • Spotting.
  • Fever.
  • Blurred vision.
  • Pain on urination.
  • Dark spots on the face.
  • Heart attack.
  • Stroke.
  • Hot flush.
  • Blood clots.
  • Reduces bone density.
  • Sleeplessness.
  • Acne.
  • Abnormal hair growth.
  • Liver and kidney problems.
  • Allergic skin rashes.

As Meprate has many possible side effects and drug interactions, it is better to consult a gynecologist before taking this medicine. Your doctor will weigh the risks and benefits of you taking this medicine and will prescribe it accordingly. Self-medication is not advisable.

 
Last reviewed at: 21.Dec.2018

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