Drug and Supplements

Meprate 10 MG Tablet

Written by
Dr. Sneha Kannan
and medically reviewed by Dr. Richa Agarwal

Published on Dec 21, 2018   -  4 min read

Abstract

Abstract

Meprate is a progestin (a form of progesterone), which is used as a contraceptive pill. It inhibits ovulation by inhibiting LH surge and follicular development. Meprate is used to regularize the menstrual cycle as it has progestin, which is a form of the hormone progesterone.

Meprate 10 MG Tablet

Overview:

Meprate is a progestin (a form of progesterone), which is used as a contraceptive pill. It inhibits ovulation by inhibiting LH surge and follicular development. Meprate is used to regularize the menstrual cycle as it has progestin, which is a form of the hormone progesterone. Progesterone is responsible for the shedding of the endometrium (inner lining of the uterus) during menstruation, so it is also used to prevent thickening of the endometrium. It is also used in a higher dose as a contraceptive.

Composition:

Medroxyprogesterone acetate is the progestin that is found in Meprate tablets. It is available as 2.5 mg, 5 mg, and 10 mg tablets, which is taken orally. It is the synthetic form of progesterone hormone. If the body lacks natural progesterone, then this tablet is used to replace it.

Uses:

Medroxyprogesterone is used to:

  • Prevent thickening of the inner lining of the uterus (endometrial hyperplasia). As a result, prevents cancer from developing in the uterus.
  • Reduce symptoms of menopause like hot flush (Hormone Replacement Therapy).
  • Stop abnormal bleeding from the uterus.
  • Induce periods in women having amenorrhea (absence of periods).
  • As a contraceptive.

Medroxyprogesterone acetate prevents pregnancy by preventing the proper development of ovum by reducing the secretion of Gonadotropin-releasing hormone (GnRH) from the hypothalamus. It also increases the mucus secretion in the cervix, making it hard for the sperm to reach the egg.

Endometrial hyperplasia is the thickening of the endometrium due to more estrogen in the absence of progesterone. Due to the lack of progesterone, the uterine lining keeps getting deposited because of estrogen. In such a case, progestin helps shed the endometrium and prevents its thickening. Endometrial hyperplasia may lead to uterine cancer.

Dosage:

Meprate is available as a 2.5 mg, 5 mg, and 10 mg tablet. The dosage varies according to the condition you are using it for, so it is essential to consult your doctor before taking this medicine. For example,

1. For abnormal or irregular menstrual bleeding or amenorrhea: The usual dosage is 5 or 10 mg daily for 10 days, starting from the 16th day of the menstrual cycle.

2. For endometrial hyperplasia prevention: 5 or 10 mg every day for 12 to 14 consecutive days every month.

The tablet should be taken as a whole, without crushing or chewing it. For best results, it should be taken at a fixed time every day. In case you forget to take a dose, take the next dose when you remember. If it is already time to take the next dose, then do not take the missed dose. It is not advisable to double the doses.

Overdose:

This tablet should not be taken more than the prescribed dosage. The overdose of progestin may cause nausea, vomiting, stomach pain, dizziness, tiredness, withdrawal bleeding, etc. If these symptoms occur, stop taking this medicine.

Substitutes:

1.Tablet Deviry.

2.Tablet Provera.

3.Tablet Medolin.

4.Tablet Regeeva.

5.Tablet Medrogest.

6.Tablet Modus.

Contraindications:

Medroxyprogesterone acetate should be avoided in the following conditions:

  • Vaginal bleeding of unknown cause.
  • Impaired liver function.
  • Pregnancy.
  • Uncontrolled diabetes.
  • Uncontrolled hypertension.
  • History of mental illness or depression.
  • Allergic to Medroxyprogesterone.

Drug Warnings and Precautions:

It is important to inform your treating doctor about any pre-existing health condition or any allergy. Medroxyprogesterone acetate should be avoided or taken with precaution if you have any of the following condition:

• While on this tablet, if you feel chest pain, dizziness, shortness of breath, headache, pain in the groin, and slurred speech, get medical assistance right away. This is because the tablet increases the risk of heart disease and stroke.

• It might cause pancreatitis (inflammation of the pancreas). Inform the doctor immediately if you develop severe abdominal pain, fever, chills, nausea, vomiting, etc.

• If you are pregnant or suspect pregnancy, then stop the drug and inform your doctor, as it can affect the fetus.

• Smoking should be avoided, as it increases the risk of stroke.

• The risk of heart disease is high if you are obese, diabetic or have high cholesterol.

• There is also a risk of blood clots, heart attack, stroke, breast and uterine cancer with this drug.

Tell your doctor if you have a history of any heart disease, stroke, blood clots, cancer, asthma, diabetes, epilepsy, hypertension, kidney disease, liver disease or any thyroid problem. Some precautions and dosage might need to be altered depending on the condition.

Drug Interactions:

Certain drugs that you are already taking might interact with this medicine and increase or decrease the effectiveness of the drug or cause side effects. The drugs that might interact with Meprate are:

1.Aminoglutethimide.

2.Rifampin.

3.Itraconazole.

4.Tranexamic acid.

5.Phenytoin.

6.Phenobarbital.

7.Isotretinoin.

8.Warfarin.

9.Ritonavir.

10.Cyclosporine.

Side Effects:

The following side effects may occur while taking this tablet:

  • Nausea
  • Vomiting.
  • Abdominal cramps.
  • Mood swings.
  • Dizziness.
  • Headache.
  • Decrease urine output.
  • Pain in the breast.
  • Depression.
  • Puffy eyes.
  • Weakness.
  • Weight gain or loss.
  • Spotting.
  • Fever.
  • Blurred vision.
  • Pain on urination.
  • Dark spots on the face.
  • Heart attack.
  • Stroke.
  • Hot flush.
  • Blood clots.
  • Reduces bone density.
  • Sleeplessness.
  • Acne.
  • Abnormal hair growth.
  • Liver and kidney problems.
  • Allergic skin rashes.

As Meprate has many possible side effects and drug interactions, it is better to consult a gynecologist before taking this medicine. Your doctor will weigh the risks and benefits of you taking this medicine and will prescribe it accordingly. Self-medication is not advisable.

Frequently Asked Questions


1.

Can Meprate be used to delay periods?

Meprate will delay periods if you start taking it a few days before the date of your periods. You will mostly not get your periods for as long as you take the tablet. Once you stop, you will have some withdrawal bleeding in a few days. Never take this tablet without consulting a doctor.

2.

Can Meprate be used to avoid pregnancy?

Meprate contains Progestin, which is used as a contraceptive. Meprate prevents pregnancy by preventing ovulation and the endometrium from thickening if taken in higher doses. It is also used to treat irregular menstruation, prevent cancer, and reduce symptoms of menopause.

3.

Is Meprate a birth control pill?

Yes, Meprate is made of Progestin, which is the synthetic form of the hormone progesterone. It is used in contraceptives (if taken in higher doses) and in hormone replacement therapy after menopause.

4.

How long should one wait to get periods after taking Meprate 10 mg?

Usually, Meprate is taken twice for 5 days and then stopped. After stopping the tablet, it may take 7 to 10 days for the periods to start.

5.

Does Meprate damage the kidneys?

Meprate does not damage your kidneys. But if you have a pre-existing kidney condition, then it might worsen it. So always tell your doctor about any kidney disease before he or she prescribes this medicine.

6.

What is Meprate used for?

Meprate is used to regulate irregular menstrual periods, prevent endometrial hyperplasia, reduce symptoms of menopause, prevent abnormal uterine bleeding, induce periods, and in large doses as a contraceptive.

7.

Does ovulation occur after taking Meprate for five days?

Meprate may interfere with ovulation. So you might not ovulate after you induce periods with the help of this medicine.

8.

Will Meprate affect the baby if taken while pregnant?

Medroxyprogesterone, if taken during pregnancy, can affect the baby. It might not cause abortion but can cause some bleeding. Some studies have found that taking Meprate during the first trimester increases the incidence of birth defects.

9.

Does Medroxyprogesterone cause constipation?

Yes, constipation is a side effect of Medroxyprogesterone tablets.

Last reviewed at:
21 Dec 2018  -  4 min read

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