Mutation of the CALR gene is associated with neoplasms (abnormal growth of tissue) of the bone marrow that eventually leads to excessive production of red blood cells. CALR gene mutations form a part of blood disorders collectively known as myeloproliferative neoplasms.
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Do I need to worry on the detection of CALR exon 9 mutation?
Query: Hello doctor, I am a 46-year-old male. A month ago, I had a heart stroke and underwent angio for blood clotting thrombus. My CBC report at that time shows a platelet count at 24 lakhs. I received CALR Exon 9 mutation analysis report today. It reads "CALR Exon 9 mutation is detected by PCR amplificat... Read Full »
Answer: Hello, Welcome to icliniq.com. You have very high levels of platelets which are called 'primary thrombocytosis' or 'essential thrombocytosis', which was confirmed by CALR Gene mutation test. This condition will results in either clots or sometimes bleeding in any part of the body. There are few t... Read Full »