Fourth Generation Hiv Test

HIV is a sexually transmitted disease which is caused by human immunodeficiency virus. There are various tests to detect the presence of HIV antigens/antibodies. These tests have evolved over time. A fourth-generation test identifies HIV antibodies as well as p24 antigens from the sample. Therefore, this test is more sensitive and helps identify the infection much earlier than a third generation test.

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All the answers published in this website are written by Verified medical doctors, therapists and health experts. The Content has been moderated by iCliniq medical review team before publication. Post your medical clarifications on iCliniq by choosing the right specialty and get them answered. Your medical queries will be answered 24/7 by top doctors from iCliniq.

Does random tenderness with swollen underarm lymphnode signify HIV infection?

Query: Hello doctor, I am 29-year-old, married male. I have a baby who feeds on breast milk. I had a sexual encounter before 8 months with a professional with a condom. I am 95% sure that my protection was intact. Then I started reading about the HIV symptoms and technicalities of testing online. Five day...  Read Full »


Dr. Bharatesh Devendra Basti

Community Medicine Physician, Dermatologist, HIV AIDS Specialist, Preventive Medicine Physician, Venereologist

Answer: Hi, Welcome to icliniq.com. The chances of transmission of HIV by the given description is almost nil. HIV tests are repeatedly negative and after three months of exposure it is conclusive. You are free from HIV. There is no need for you to worry about seroconversion. You can forget about the epi...  Read Full »

Is it not necessary to do other tests if fourth generation test negative at 8th week?

Query: Hi doctor, I went for an HIV test at six weeks after low-risk exposure and get false positive. At eight weeks both fourth generation and HIV RNA PCR are negative. At 9 and 10 weeks rapid test is negative. At 12 weeks HIV RNA PCR is negative. Is it conclusive? My doctor told me no need for further t...  Read Full »


Dr. Ravinder Kaur Sachdeva

HIV AIDS Specialist

Answer: Hello, Welcome back to icliniq.com. To answer your query, I want to give reference of published research that, Although the reported sensitivity and specificity of fourth generation tests are more than 99% in numerous studies, there are several instances of discordance between screening and confir...  Read Full »

I have done HIV RNA and 4th generation tests and are negative. Do I still have HIV risk?

Query: Hi doctor, About a month ago, I had protected sex with a woman and unprotected oral sex with her as well. Then two days after that I had unprotected oral sex and fingered a different woman. Five days later, I got a low fever of about 99 degrees. The following day I got chills, night sweats, joint...  Read Full »


Dr. Anshul Varshney

Criticalcare Physician, Diabetologist, General Medicine Physician, Internal Medicine Physician, Medical Gastroenterologist, Nephrologist, Pulmonologist, Rheumatologist

Answer: Hi, Welcome to icliniq.com. See, a rash does not confirm the diagnosis of HIV. A rash is a very common finding in viral Infection and you could have got the viral infection from your partners only. Luckily this time the virus was not HIV. The fourth generation PCR tests are highly sensitive and henc...  Read Full »

I feel burning pain in feet and leg after unprotected sex. Is it HIV neuropathy?

Query: Hello doctor, How conclusive are three months negative HIV fourth generation duo test? I did an unprotected vaginal and oral sex with a prostitute and have feet and leg burning pain, prickling, tingling in feet and hand fingers. Is there any test that tells I am 100% HIV free? My doctor told me it...  Read Full »


Dr. Arul Amuthan

Ayurveda Specialist, Naturopathy Specialist, Pharmacologist, Siddha Medicine Specialist, Toxicologist

Answer: Hello, Welcome to icliniq.com. Generally, the HIV infection takes few days to years to produce the symptoms (it is called as incubation period). The incubation period is not fixed in HIV infection. It is the time taken for the organism to establish itself within the human body. As all of us know t...  Read Full »

Is retest necessary after a negative fourth generation antigen-antibody test?

Query: Hello doctor, I had two sexual encounters with women whom I do not know their HIV status. Both were vaginal and a condom was worn. In the fourth and fifth weeks, I had a fourth-generation antibody-antigen test performed and it came back negative. Should I be retested again?  Read Full »


Dr. Sadaf Mustafa

General Medicine Physician, Internal Medicine Physician

Answer: Hello, Welcome to icliniq.com. It is a good idea to get repeat testing, here is why. The antibody testing at the fourth and fifth weeks can give you some idea of the HIV (human immuno deficiency virus) status, but the one at 12 weeks after the exposure will confirm the negative status completely....  Read Full »

Are HIV-1 RNA and QL TMA tests for HIV conclusive?

Query: Hello doctor, I had two negative Gen-Probe Aptima RNA TMA test done the on the 8th day and 14th day of post exposure. I took a Duo Combo test on the 29th day. Has anyone seen these RNA tests after 14 days have become wrong?  Read Full »


Dr. Jyotisterna Mittal

Dermatologist, Venereologist, HIV AIDS Specialist, Cosmetologist, Family Physician, General Practitioner

Answer: Hi, Welcome to icliniq.com. You need not go for further testing as these tests are conclusive. For further information consult a HIV AIDS specialist online --> https://www.icliniq.com/ask-a-doctor-online/HIV-AIDS-specialist  Read Full »

Am I negative for HIV 2 if DNA nad RNA PCR tests remain negative after 3 months of exposure?

Query: Hi doctor, Do you have any experience in HIV 2? I have done my HIV 2 DNA/RNA PCR test and antibody test which came back both negative after three months. What I am worried is HIV 2 is a slowly replicating virus and worry that HIV 2 DNA/RNA PCR test cannot pick up even after three months. Is it true...  Read Full »


Dr. Kiran Anaparthi

Family Physician, HIV AIDS Specialist

Answer: Hi, Welcome to icliniq.com. The replication of the virus has no relationship in the detection of the virus. If the virus is present in the body, the immune system will detect it, and start defending the body by producing antibodies. This procedure does not need any replication of the virus. It jus...  Read Full »

Can you catch the flu from having intercourse?

Query: Hi doctor, I had sex with a girl I know. The condom broke while having sex. After 30 minutes, I started having the headache. I was distraught. I took the antibiotics. After two days, I had a cold. Can HIV symptoms appear this fast? Or it was because I took the antibiotics? Or I am just panicking?  Read Full »


Dr. Jyotisterna Mittal

Dermatologist, Venereologist, HIV AIDS Specialist, Cosmetologist, Family Physician, General Practitioner

Answer: Hi, Welcome to icliniq.com. HIV (human immunodeficiency virus) symptoms cannot appear so soon. It may be due to an anxiety or just a coincidence. For further queries consult a dermatologist online --> https://icliniq.com./ask-a-doctor-online/dermatologist  Read Full »

Which test can be used to confirm HIV?

Query: Hello doctor,The last exposure was a year back, had pin-prick sensations on head and arms. After three months, I had three HIV tests, two were blood and one rapid test oral. Eight months later, I had a PCR RNA qualitative and another fourth-generation blood test antigen and antibody, both were negat...  Read Full »


Dr. Kiran Anaparthi

Family Physician, HIV AIDS Specialist

Answer: Hi, Welcome to icliniq.com. As per description, you are more obsessed with HIV rather than the actual scenario. Any infection will have a remnant in the body, called the footprint of the infection. In case of HIV, the virus leaves its particles in the body, of which p24 is the core protein that prot...  Read Full »

Screened for HIV after eight weeks of exposure. Is it reliable?

Query: Hi doctor, I did an HIV rapid screening after eight weeks of exposure, and the results came negative. I do not have any other symptoms of HIV. Is this result reliable? Do I need to do other tests?  Read Full »


Dr. Ravinder Kaur Sachdeva

HIV AIDS Specialist

Answer: Hi, Welcome to icliniq.com. The tests available for HIV diagnosis are highly sensitive and specific and gives accurate results. Majority of the people who are infected with HIV develop HIV antibodies by two to eight weeks. Approximately, up to 5 % develop seroconversion by 12 weeks. Your HIV negat...  Read Full »

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