Fourth Generation Hiv Test

HIV is a sexually transmitted disease which is caused by human immunodeficiency virus. There are various tests to detect the presence of HIV antigens/antibodies. These tests have evolved over time. A fourth-generation test identifies HIV antibodies as well as p24 antigens from the sample. Therefore, this test is more sensitive and helps identify the infection much earlier than a third generation test.

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All the answers published in this website are written by Verified medical doctors, therapists and health experts. The Content has been moderated by iCliniq medical review team before publication. Post your medical clarifications on iCliniq by choosing the right specialty and get them answered. Your medical queries will be answered 24/7 by top doctors from iCliniq.

Why do I get itching and burning sensation in hands with muscle pain after risky sexual exposure?

Query: Hello doctor, Before three months, I had unprotected sex with a sex worker in her monthly (menstrual) period. After sex, I noticed bleeding from my cut penis. After one week, pain subsided. And after a month, I had sex, and again noticed bleeding from penis wound. I again had protected sex with se...  Read Full »


Dr. Ravinder Kaur Sachdeva

HIV AIDS Specialist

Answer: Hi, Welcome to icliniq.com. The recommendations are to get the fourth generation HIV rapid test at the third or fourth week of the exposure. If the result is negative, get a confirmatory HIV rapid antibody test at 90 days (three months) of last exposure. Your negative HIV test result at three mont...  Read Full »

What test should I undergo to confirm my HIV status?

Query: Hi doctor, I am sexually active for the past three years, but I have never checked my HIV nor done any tests. But, I had sex with a sex worker with protection but still got scared it has been seven months. I did not have sex. What test do I need to do? Do I need to test? I used a condom, and I hear...  Read Full »


Dr. Ashok Kumar Choudhary

Andrologist, General Practitioner, Geriatrician, Psychiatrist, Psychologist Counsellor, Psychotherapist, Sexologist

Answer: Hello, Welcome to icliniq.com. First of all, I like to inform you that getting HIV while using condom/protection is very low and almost negligible. In other words, it can be stated that the chance is almost nil. Regarding the test, I feel Elisa for HIV will be most suitable for you as the exposur...  Read Full »

Are sore throat and pain at the base of the penis signs of HIV?

Query: Hi doctor, I had unprotected sex, and after that, four weeks later, I got a CMIA combo test (fourth generation) done. It is non-reactive. Now I have a sore throat and nerve like pain at the base of my penis. What are the chances of getting positive? How accurate are the fourth generation tests afte...  Read Full »


Dr. Bharatesh Devendra Basti

Community Medicine Physician, Dermatologist, HIV AIDS Specialist, Preventive Medicine Physician, Venereologist

Answer: Hi, Welcome to icliniq.com. Thank you for the query. The fourth-generation HIV (Human immunodeficiency viruses) antibody test is almost considered conclusive after one-month exposure. But it would be better to go for an HIV antibody test after three months of exposure to have final, conclusive re...  Read Full »

Can I rely on fourth-generation HIV test result after six months of exposure?

Query: Hello doctor, How accurate is HIV test after six months? What are the things that affect or delay the HIV test? I am taking Ashwaghanda, does it delay my test? When should I test if I have an autoimmune disease?  Read Full »


Dr. Purushottam Sah

Obstetrician And Gynaecologist, Sexologist, Andrologist, Infertility Specialist

Answer: Hello, Welcome to icliniq.com. There is a window period of three months after an exposure in which the HIV antibody test may come negative, but six months is a good enough time for the test to become reliable. Ashwagandha does not affect the test. Even if you have autoimmune disease, it means you...  Read Full »

Will certain medicines interfere with HIV test results?

Query: Hello doctor, Does Ashwagandha delay on HIV test? Does any medicine delay on HIV test? How accurate is the HIV test in six months with the fourth generation?  Read Full »


Dr. Penchala Prasad Kandikattu

General Medicine Physician, Internal Medicine Physician

Answer: Hello, Welcome to icliniq.com. Usually, Ashwagandha shows some beneficial results like neuroprotective effect or boosting immunity in HIV (human immunodeficiency virus) positive patients on a part of the treatment plan. But it is not going to delay any HIV test. Usually, after exposure to HIV ...  Read Full »

Does random tenderness with swollen underarm lymphnode signify HIV infection?

Query: Hello doctor, I am 29-year-old, married male. I have a baby who feeds on breast milk. I had a sexual encounter before 8 months with a professional with a condom. I am 95% sure that my protection was intact. Then I started reading about the HIV symptoms and technicalities of testing online. Five day...  Read Full »


Dr. Bharatesh Devendra Basti

Community Medicine Physician, Dermatologist, HIV AIDS Specialist, Preventive Medicine Physician, Venereologist

Answer: Hi, Welcome to icliniq.com. The chances of transmission of HIV by the given description is almost nil. HIV tests are repeatedly negative and after three months of exposure it is conclusive. You are free from HIV. There is no need for you to worry about seroconversion. You can forget about the epi...  Read Full »

Is it not necessary to do other tests if fourth generation test negative at 8th week?

Query: Hi doctor, I went for an HIV test at six weeks after low-risk exposure and get false positive. At eight weeks both fourth generation and HIV RNA PCR are negative. At 9 and 10 weeks rapid test is negative. At 12 weeks HIV RNA PCR is negative. Is it conclusive? My doctor told me no need for further t...  Read Full »


Dr. Ravinder Kaur Sachdeva

HIV AIDS Specialist

Answer: Hello, Welcome back to icliniq.com. To answer your query, I want to give reference of published research that, Although the reported sensitivity and specificity of fourth generation tests are more than 99% in numerous studies, there are several instances of discordance between screening and confir...  Read Full »

I have done HIV RNA and 4th generation tests and are negative. Do I still have HIV risk?

Query: Hi doctor, About a month ago, I had protected sex with a woman and unprotected oral sex with her as well. Then two days after that I had unprotected oral sex and fingered a different woman. Five days later, I got a low fever of about 99 degrees. The following day I got chills, night sweats, joint...  Read Full »


Dr. Anshul Varshney

Criticalcare Physician, Diabetologist, General Medicine Physician, Internal Medicine Physician, Medical Gastroenterologist, Nephrologist, Pulmonologist, Rheumatologist

Answer: Hi, Welcome to icliniq.com. See, a rash does not confirm the diagnosis of HIV. A rash is a very common finding in viral Infection and you could have got the viral infection from your partners only. Luckily this time the virus was not HIV. The fourth generation PCR tests are highly sensitive and henc...  Read Full »

I feel burning pain in feet and leg after unprotected sex. Is it HIV neuropathy?

Query: Hello doctor, How conclusive are three months negative HIV fourth generation duo test? I did an unprotected vaginal and oral sex with a prostitute and have feet and leg burning pain, prickling, tingling in feet and hand fingers. Is there any test that tells I am 100% HIV free? My doctor told me it...  Read Full »


Dr. Arul Amuthan

Ayurveda Specialist, Naturopathy Specialist, Pharmacologist, Siddha Medicine Specialist, Toxicologist

Answer: Hello, Welcome to icliniq.com. Generally, the HIV infection takes few days to years to produce the symptoms (it is called as incubation period). The incubation period is not fixed in HIV infection. It is the time taken for the organism to establish itself within the human body. As all of us know t...  Read Full »

Is retest necessary after a negative fourth generation antigen-antibody test?

Query: Hello doctor, I had two sexual encounters with women whom I do not know their HIV status. Both were vaginal and a condom was worn. In the fourth and fifth weeks, I had a fourth-generation antibody-antigen test performed and it came back negative. Should I be retested again?  Read Full »


Dr. Sadaf Mustafa

General Medicine Physician, Internal Medicine Physician

Answer: Hello, Welcome to icliniq.com. It is a good idea to get repeat testing, here is why. The antibody testing at the fourth and fifth weeks can give you some idea of the HIV (human immuno deficiency virus) status, but the one at 12 weeks after the exposure will confirm the negative status completely....  Read Full »

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