Gilbert's Syndrome

"Gilbert's syndrome is a genetic liver disorder in which the liver cannot properly process bilirubin. People with this syndrome do not produce enough liver enzymes to keep bilirubin levels normal, leading to excess bilirubin building up in the body (hyperbilirubinemia). As a result, Gilbert's syndrome may present with dark-colored urine or clay-colored stool, dizziness, diarrhea, nausea, flu-like symptoms, and loss of appetite. Gilbert's syndrome does not require any treatment. The high bilirubin levels in the blood may fluctuate over time and lead to jaundice occasionally, which usually resolves on its own with no side effects.


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I have Gilbert's syndrome. Does my elevated ALT levels suggest a liver problem?

Query: Hello doctor, A year ago, I had an ultrasound scan done. I have attached the images. The reports showed elevated bilirubin levels, but they never explained my ultrasound reports to me. However, I saw a GI and had endless bloodwork done to rule out any liver diseases like Wilson's disease, hemochroma...  Read Full »

Dr. J. N. Naidu

Answer: Hi, Welcome to I read your query and understand your concern. I understand your anxiety. Please understand that Gilbert's syndrome is a relatively benign condition. It is usually diagnosed accidentally when routine blood tests are performed. It occurs due to the mutation of a biochem...  Read Full »

My indirect bilirubin levels are high. Should I be worried?

Query: Hi doctor, I was initially in the hospital with heartburn. They performed a CT scan and ultrasound, and it showed a mild fatty liver. Bilirubin levels were 2.2, with unconjugated being high. I followed up with MD and did Bilirubin again, and it was 1.6 with elevated unconjugated levels. She then ran...  Read Full »

Dr. Ajeet Kumar Lohana

Answer: Hello, Welcome to I can understand your concern. However, I do not think that the information you provided is enough to make a diagnosis. I would need a complete history of your problem. And all the investigations that have been performed. For example, endoscopy images with biopsies rep...  Read Full »

Why is my bilirubin level a bit higher?

Query: Hello doctor, I am a 29-year-old male, weigh 90 kg, height is 182, non-smoker, non-alcohol drinker. I do not have any symptoms or signs, normal eye, and skin color. I am taking Cipralex 15 mg for the past one year. Had a history of bladder stone and it required admission for one week until it passe...  Read Full »

Dr. Babu Lal Meena

Answer: Hi, Welcome to If Mmol means micron mol, then it is fine (attachment removed to protect patient identity). It looks like a normal variant of hyperbilirubinemia. Most common cause of the condition is hemolysis, Gilbert syndrome is also a common cause of such a situation. In both the co...  Read Full »

How can I get relief from heartburn and bloating?

Query: Hello doctor, I am a 32 year old suffering from anxiety disorder, and I took some related medicines for a few years and still take Mirtazapine. I have weight issues from a couple of years. I do blood examinations regularly, which come back normal. Lately, I am having problems with heartburn. I had ...  Read Full »

Dr. Babu Lal Meena

Answer: Hi, Welcome to All the symptoms are related to bowel disturbance. This is multiple issue disorder, as you are presenting with pain, excessive burping, and heartburn. And you also have constipation. This is called IBS (irritable bowel syndrome). All the symptoms are interrelated. See if...  Read Full »

Does non-alcoholic steatohepatitis run in families?

Query: Hello doctor, I am a 28-year-old female with a height of 5'7" feet and weigh 149 pounds. Routine medical check-up found elevated bilirubin of 1.6 mg/dL. AST 23 U/L and ALT 19 U/L. Repeat laboratory tests a week later show bilirubin of 1.4 mg/dL, AST 23 U/L, ALT 19 U/L. Doctor ordered an ultrasound....  Read Full »

Dr. Sandeep V Nair

Answer: Hi, Welcome to I think it is more likely to be Gilbert Syndrome. It is a benign condition and does not require any treatment. However, to come to the diagnosis, I need to know the complete liver function test and the blood tests. If your indirect fraction is high, then it is Gilbert ...  Read Full »

My urine is foamy. Is this a symptom of any disease?

Query: Hello doctor, I am a 21-year-old male with 60 kg weight and 5’6” in height. I had kidney stones two years back with gilbert syndrome. My urine is foamy most of the time from last 1.5 years like alcohol I wanted to know, is this a symptom of any disease?  Read Full »

Dr. Raj Parekh

Answer: Hello, Welcome to Foamy urine can account to several causes like protein in urine or dehydration or urinary tract infection or diabetic infection in the kidney can also call cause foamy urine. We need to perform a few tests before we proceed to the diagnosis. With this, we will order ...  Read Full »

I do not have any symptoms of jaundice, but my bilirubin level is abnormal. Why?

Query: Hi doctor, I am a 26 year old male, and I am a triathlete. Seven years back, I suffered from jaundice. I check my blood bilirubin every six months and liver function test every year. The result showed abnormal bilirubin level; the total bilirubin was 3.5. The LFT was normal. I also got an ultrasoun...  Read Full »

Dr. Rosita Alizadeh Shalchi

Answer: Hello, Welcome to I can imagine that you are concerned about your liver. I understand that you do not have any discomfort and ultrasound is normal. Your test result is compatible with a harmless condition named Gilbert's syndrome. In this syndrome, a pigment named bilirubin is not excre...  Read Full »

Bilirubin is high but other liver functions are normal. Should I worry?

Query: Hello doctor, I did blood tests and attached are the reports. Are they alright or do I need to investigate further?  Read Full »

Dr. Singh Smrita

Answer: Hello, Welcome to I have gone through your test results (attachment removed to protect patient identity) and the only abnormality is high direct bilirubin. Higher than normal levels of direct bilirubin in your blood may indicate your liver is not clearing bilirubin properly. The most...  Read Full »

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