Mutation of the CALR gene is associated with neoplasms (abnormal growth of tissue) of the bone marrow that eventually leads to excessive production of red blood cells. CALR gene mutations form a part of blood disorders collectively known as myeloproliferative neoplasms.
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Do I need to worry on the detection of CALR exon 9 mutation?
Query: Hello doctor, I am a 46-year-old male. A month ago, I had a heart stroke and underwent angio for blood clotting thrombus. My CBC report at that time shows a platelet count at 24 lakhs. I received CALR Exon 9 mutation analysis report today. It reads "CALR Exon 9 mutation is detected by PCR amplificat... Read Full »
Answer: Hello, Welcome to icliniq.com. You have very high levels of platelets which are called 'primary thrombocytosis' or 'essential thrombocytosis', which was confirmed by CALR Gene mutation test. This condition will results in either clots or sometimes bleeding in any part of the body. There are few t... Read Full »
I have a high platelet count. what could be the reason?
Query: Hi doctor, I am a 46-year-old diabetic female. My platelet count is high at 900,000 per microliter of blood in routine CBC. My iron is normal. My USG showed hepatosplenomegaly and PBS showed microcytic hypochromic anisocytosis. What shall I do now? Read Full »
Answer: Hello, Welcome to icliniq.com. The platelet count is above the normal range. There are many reasons for such elevated platelet count. It needs further investigations, including genetic tests. The conditions like essential thrombocytosis could be considered with the available information from you.... Read Full »
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