Glucose-6-phosphate dehydrogenase is an enzyme responsible for the health of red blood cells. Its deficiency causes hemolysis or destruction of RBCs. It is a genetic disorder transmitted to children from parents with a defective gene on the X chromosome. Males have a high predisposition. In the absence of triggering factors, most people have no symptoms. Fava beans, pollen, and legumes can trigger and cause symptoms like shortness of breath, fatigue, rapid heartbeat, fever, dark urine, dizziness, and jaundice. Avoiding the triggers itself relieves the symptoms. If G6PD deficiency progresses to hemolytic anemia, blood transfusions with oxygen therapy may be needed.
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Query: Hello doctor, Last year my daughter decided to go on an all vegetarian diet rather drastically. A few weeks later, she got ill with vomiting which lasted for approximately two weeks, so we made three visits to the urgent care, where she was treated for gastritis and dehydration. One month later, the... Read Full »
Answer: Hello, Welcome to icliniq.com. I have two theories here, but I would need a little more information if you would not mind sharing. 1. Has she ever been tested for G6PD (glucose-6-phosphate dehydrogenase) deficiency? 2. During these episodes did she get a CBC (complete blood count) done? 3. Was it c... Read Full »
Query: Hi,I am a very fit person with a healthy lifestyle. All my brothers and sisters have had hereditary G6PD since birth. I have never been tested. I have no allergies or any issues. But if this condition is genetic, do I have it too? Read Full »
Answer: Hi, Welcome to icliniq.com. I read your query and understand your concern. G6PD (Glucose-6-phosphate dehydrogenase deficiency) test is indicated in newborn infants with jaundice. The test is not mandatory for all newborns. G6PD deficient people may develop a particular type of anemia called hemo... Read Full »
Query: Hello doctor, I have G6PD deficiency since childhood. Presently I am married. And soon planning to conceive. Will I have any complications in the future? How much and till what extent? Is it true that I can never become a mother if I have G6PD? Are there chances or percentage of having a healthy ch... Read Full »
Answer: Hello, Welcome to icliniq.com. Yes, G6PD deficiency certainly has effects on pregnancy. It is an X-linked recessive disorder, male babies may be affected and female babies may be carriers. Chances of inheritance vary with your partner karyotype also. The severity of symptoms varies depends on your... Read Full »
Query: Hi doctor, One of my daughters has got beta thalassemia major and G6PD deficiency. Is there any treatment for her? Please advice. Read Full »
Answer: Hello, Welcome to icliniq.com. Beta thalassemia major includes a hereditary disorder and is due to genetic deficiency of beta globin chains of hemoglobin. It is transfusion dependent anemia.Management of beta thalassemia major includesChronic transfusion to maintain hemoglobin at the range of 9-10 ... Read Full »
Query: Hi doctor, Recently, I did a series of blood tests to check my pre-existing G6PD deficiency. The results showed low G6PD levels of 0.4 units/gram of hemoglobin. I have read that anything below 10 % of the normal range can cause hemolytic anemia. Please suggest. Read Full »
Answer: Hi, Welcome to icliniq.com. I have gone through the attachment (attachment removed to protect patient identity). Your G6PD (glucose-6-phosphate dehydrogenase) level is low. But clinical correlation is needed in your case. I suggest you investigate with CBC, reticulocyte count estimation, and perip... Read Full »
Query: Hi doctor, My son is G6PD deficient. He is already 10 months old. We have been having CBC since the first month and the result is somehow close. In his latest result, just taken yesterday, RBC is 4.09 (unit:x10^12/L), hemoglobin is 112 (g/L), hematocrit is 0.33 (L/L) and WBC is 12.0 (x10^9/IL). Dif... Read Full »
Answer: Hello, Welcome to icliniq.com. Do not try or stop medication on your own. It is advisable to visit his pediatrician or hematologist for an examination. Your child's hemoglobin level remains persistently low as per history. So, chronic hemolysis or intermittent hemolysis might be there. Clinical s... Read Full »